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AR051654A1 - Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones - Google Patents

Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones

Info

Publication number
AR051654A1
AR051654A1 ARP050104548A ARP050104548A AR051654A1 AR 051654 A1 AR051654 A1 AR 051654A1 AR P050104548 A ARP050104548 A AR P050104548A AR P050104548 A ARP050104548 A AR P050104548A AR 051654 A1 AR051654 A1 AR 051654A1
Authority
AR
Argentina
Prior art keywords
proton pump
pellets
modified release
pump inhibitors
release pellets
Prior art date
Application number
ARP050104548A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36319457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051654(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR051654A1 publication Critical patent/AR051654A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una forma de dosificacion farmacéutica solida oral que comprende un inhibidor de la bomba de protones (IBP) sensible al ácido como unico fármaco activo, liberando el IBP en dos pulsos separados, uno inmediato y uno retardado. El IBP es formado en un material nucleo en la forma de pellets, los cuales son revestidos., entre otras, con una combinacion de una capa modificadora de liberacion retardada y una capa controladora del tiempo de retardo que juntas logran propiedades de liberacion beneficiosas. Los pellets están provistos además de una capa de revestimiento entérico. La solicitud también se refiere a procesos para la preparacion de las formas de dosificacion así como también a su utilizacion en el tratamiento de enfermedades gastrointestinales.
ARP050104548A 2004-11-04 2005-10-31 Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones AR051654A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62562104P 2004-11-04 2004-11-04

Publications (1)

Publication Number Publication Date
AR051654A1 true AR051654A1 (es) 2007-01-31

Family

ID=36319457

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104548A AR051654A1 (es) 2004-11-04 2005-10-31 Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones

Country Status (17)

Country Link
US (1) US20080095853A1 (es)
EP (1) EP1809263A4 (es)
JP (1) JP2008519069A (es)
KR (1) KR20070073867A (es)
CN (1) CN101094660A (es)
AR (1) AR051654A1 (es)
AU (1) AU2005301368A1 (es)
BR (1) BRPI0517933A (es)
CA (1) CA2584417A1 (es)
IL (1) IL182696A0 (es)
MX (1) MX2007004986A (es)
NO (1) NO20072254L (es)
RU (1) RU2007115537A (es)
TW (1) TW200624127A (es)
UY (1) UY29192A1 (es)
WO (1) WO2006049564A1 (es)
ZA (1) ZA200703112B (es)

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CN102406628A (zh) * 2010-09-26 2012-04-11 上海复星普适医药科技有限公司 一种稳定的埃索美拉唑肠溶小丸的制备方法
DE102010052847A1 (de) * 2010-11-29 2012-05-31 Temmler Werke Gmbh Verfahren zur Herstellung einer PPI-haltigen pharmazeutischen Zubereitung
KR101698041B1 (ko) * 2010-12-03 2017-01-19 닛뽕소다 가부시키가이샤 하이드록시알킬셀룰로오스
NZ613090A (en) * 2010-12-29 2015-11-27 Reddy’S Lab Inc Dr Modified release benzimidazole formulations
CN103565770A (zh) * 2012-07-31 2014-02-12 北京阜康仁生物制药科技有限公司 一种右兰索拉唑肠溶缓控释微丸片
JP5819800B2 (ja) * 2012-10-31 2015-11-24 信越化学工業株式会社 高粘度ヒプロメロースを分散したコーティング液及び固形製剤の製造方法
CN104586809A (zh) * 2015-01-08 2015-05-06 浙江亚太药业股份有限公司 一种埃索美拉唑镁微丸肠溶片及制备方法
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
KR101884230B1 (ko) * 2016-02-29 2018-08-01 주식회사 유영제약 에소메프라졸을 포함하는 제제
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN111991367A (zh) * 2020-09-21 2020-11-27 青岛吉达巴尔国际贸易有限公司 一种埃索美拉唑镁脉冲微丸胶囊剂及制备方法
WO2022154687A1 (ru) * 2021-01-14 2022-07-21 Общество C Ограниченной Ответственностью "Новамедика" Фармацевтическая композиция, включающая эзомепразол

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IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
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JPH07223970A (ja) * 1994-02-10 1995-08-22 Tanabe Seiyaku Co Ltd 消化管内適所放出製剤
US5945124A (en) * 1995-07-05 1999-08-31 Byk Gulden Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
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SE9600072D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients II
CA2173818A1 (fr) * 1996-04-10 1997-10-11 Francois Chouinard Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
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Also Published As

Publication number Publication date
CA2584417A1 (en) 2006-05-11
NO20072254L (no) 2007-07-30
CN101094660A (zh) 2007-12-26
BRPI0517933A (pt) 2008-10-21
WO2006049564A1 (en) 2006-05-11
AU2005301368A1 (en) 2006-05-11
IL182696A0 (en) 2007-09-20
WO2006049564A8 (en) 2007-06-07
EP1809263A4 (en) 2012-09-26
EP1809263A1 (en) 2007-07-25
ZA200703112B (en) 2008-10-29
TW200624127A (en) 2006-07-16
JP2008519069A (ja) 2008-06-05
UY29192A1 (es) 2006-06-30
RU2007115537A (ru) 2008-12-10
US20080095853A1 (en) 2008-04-24
MX2007004986A (es) 2007-06-14
KR20070073867A (ko) 2007-07-10

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