AR049184A1 - Procedimiento para la preparacion de derivados de 1, 4 - difenilazetidinona en presencia de agentes de sililacion y de un catalizador de ciclacion - Google Patents
Procedimiento para la preparacion de derivados de 1, 4 - difenilazetidinona en presencia de agentes de sililacion y de un catalizador de ciclacionInfo
- Publication number
- AR049184A1 AR049184A1 ARP050102099A ARP050102099A AR049184A1 AR 049184 A1 AR049184 A1 AR 049184A1 AR P050102099 A ARP050102099 A AR P050102099A AR P050102099 A ARP050102099 A AR P050102099A AR 049184 A1 AR049184 A1 AR 049184A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- coo
- substituted
- catalyst
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Para la preparacion de derivados de 1,4-difenilazetidinona caracterizado porque comprende preparar dichos derivados a partir de aminoamidas Beta-sustituidas protegidas de manera adecuada, en presencia de agentes de sililacion y al menos un catalizador de ciclacion, en donde este catalizador de ciclacion se representa por la formula general (1), como cation, en donde R16, R17, R18, R19 significan, independientemente uno de otro, arilo, alquilo-(C1-15), bencilo, R41 significa arilo, alquilo-(C1-15), bencilo, R42 significa alquilo-(C1-15), bencilo, cicloalquilo-(C5-8), arilo, en donde arilo puede estar sustituido con F, Cl, Br, I, -OH, -Oalquilo-(C1-3), -NH2, -NHalquilo-(C1-3), -N[alquilo-(C1-3]2, -C(O)OH, -C(O)Oalquilo- (C1-3), -C(O)NH2, -C(O)NHalquilo-(C1-3), -C(O)N[alquilo-(C1-3]2, -SO2NH2, -SO2NHalquilo-(C1-3), -SO2N[alquilo-(C1-3)]2, -CN, alquilo-(C1-12) y cicloalquilo-(C5-8), y el grupo de formulas (2) como anion, y los símbolos, sustituyentes e índices tienen el siguiente significado, Z= C=O, C=S, S=O, SO2 o C=NR20; K = O, S, NR21 o CR22R23; L = NR24 o CR25R26; n = 0 o 1; M = O, C=O, NR27 o CR28R29; Q = O, S, NR30, CR31R32, C=O, C=S, S=O, SO2 o C=NR34; R = CR35 o N; T = CR36 o N; U = CR37 o N; V = CR38 o N, en donde R20 a R32 y R34 a R38, independientemente uno de otro, significan H, alquilo-(C1-6), arilo o heteroarilo, y en cada caso dos radicales alquilo juntos pueden formar también un radical cicloalquileno de como máximo 6 eslabones de C en el anillo, el cual, de nuevo, puede estar sustituido con F, Cl, Br, I, CF3, NO2, COO-alquilo-(C1-6), CON[alquilo-(C1-6)]2, cicloalquilo, alquilo-(C1-10), alquenilo-(C2-6). O-alquilo-(C1-6), O-CO-alquilo-(C1-6), O-CO-alquilen-(C1-6)arilo, SO2N[alquilo- (C1-6)]2, S-alquilo-(C1-6), S-(CH2-)n arilo, SO-alquilo-(C1-6)SO-(CH2-)n arilo, SO2-alquilo-(C1-6), SO2-(CH2-)n arilo, SO2-N(alquil-(C1-6))-(CH2-)n arilo, o SO2-N((CH2-)n arilo)2, en donde n puede ser 0 a 6 y el radical arilo puede estar sustituido hasta dos veces con F, Cl, Br, CF3, SF5, NO2, OCF3, O-alquilo-(C1-6) o alquilo-(C1-6); o con N(alquilo-(C1-6))2, NH-CO-NH-alquilo-(C1-6), NH-CO-NH-arilo, N[alquil-(C1-6)]-CO-alquilo-(C1-6), N[alquil-(C1-6)]-COO-alquilo-(C1-6), N[alquil-(C1-6)]-CO- arilo, N[alquil-(C1-6)]-COO-arilo, N[alquil-(C1-6)]-CO-N(alquilo-(C1-6))2, N[alquil-(C1-6)]-CO-N(alquil-(C1-6))-arilo, N[alquil-(C1-6)]-CO-N(arilo)2, N(aril)CO-alquilo-(C1-6), N(aril)-COO-alquilo-(C1-6), N(aril)-CO-arilo, N(aril)-COO-arilo, N(aril)- CO-N(alquilo-(C1-6))2, N(aril)-CO-N[alqul-(C1-6)]-arilo, N(aril)-CO-N(arilo)2, arilo, O-(CH2-)n arilo, en donde n puede ser 0 a 6, en donde el radical arilo puede estar sustituido, 1 a 3 veces, con F, Cl, Br, I, CF3, NO2, OCF3, O-alquilo-(C1-6), alquilo-(C1-6), N(alquilo-(C1-6))2, SF5, SO2, CH3 o COO-alquilo-(C1-6) y en donde R39 y R40, independientemente uno de otro, significan alquilo-(C1-6), en donde uno o más átomos de C contiguos pueden estar reemplazados por NH o C=O, perfluoroalquilo- (C1-6), arilo o heteroarilo, o R39 y R40 forman juntos un 1,8-naftilo o 1,7,7-trimetil-biciclo[2.2.1]heptanilo, R40 puede ser también H, o en donde en este catalizador de ciclacion el cation corresponde al de la formula general (1) y el anion es R41O-, o en donde en este catalizador de ciclacion el cation corresponde al de la formula general (1), y el anion es R42COO-, o en donde en este catalizador de ciclacion el cation corresponde al de la formula general (1), y el anion es Cl-, Br-, I- y éste se puede combinar con Ag2O.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200410025071 DE102004025071B4 (de) | 2004-05-21 | 2004-05-21 | Verfahren zur Herstellung von Diphenylazetidinon-Derivaten |
| DE102005010770A DE102005010770A1 (de) | 2005-03-09 | 2005-03-09 | Verfahren zur Herstellung von 1,4-Diphenylazetidinon-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049184A1 true AR049184A1 (es) | 2006-07-05 |
Family
ID=37561403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102099A AR049184A1 (es) | 2004-05-21 | 2005-05-20 | Procedimiento para la preparacion de derivados de 1, 4 - difenilazetidinona en presencia de agentes de sililacion y de un catalizador de ciclacion |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7488818B2 (es) |
| EP (1) | EP1756049B1 (es) |
| JP (1) | JP2007538042A (es) |
| KR (1) | KR20070027554A (es) |
| AR (1) | AR049184A1 (es) |
| AT (1) | ATE376997T1 (es) |
| AU (1) | AU2005245124A1 (es) |
| BR (1) | BRPI0510150A (es) |
| CA (1) | CA2567149A1 (es) |
| CY (1) | CY1107425T1 (es) |
| DE (1) | DE502005001841D1 (es) |
| DK (1) | DK1756049T3 (es) |
| ES (1) | ES2294712T3 (es) |
| HK (1) | HK1103296A1 (es) |
| HR (1) | HRP20070570T3 (es) |
| IL (1) | IL178991A0 (es) |
| MA (1) | MA28635B1 (es) |
| MX (1) | MXPA06013456A (es) |
| NZ (1) | NZ551413A (es) |
| PL (1) | PL1756049T3 (es) |
| PT (1) | PT1756049E (es) |
| RS (1) | RS50539B (es) |
| RU (1) | RU2380361C2 (es) |
| TW (1) | TW200611896A (es) |
| UY (1) | UY28912A1 (es) |
| WO (1) | WO2005113496A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| CA2550215A1 (en) | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
| JP2007516287A (ja) * | 2003-12-23 | 2007-06-21 | メルク エンド カムパニー インコーポレーテッド | 抗高コレステロール血症化合物 |
| UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| MY148538A (en) | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| US20090047716A1 (en) * | 2007-06-07 | 2009-02-19 | Nurit Perlman | Reduction processes for the preparation of ezetimibe |
| US9388440B2 (en) | 2009-04-01 | 2016-07-12 | Mylan Laboratories Limited | Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe |
| US9951008B2 (en) | 2009-11-03 | 2018-04-24 | University Of Notre Dame Du Lac | Ionic liquids comprising heteraromatic anions |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9670237B2 (en) | 2011-09-22 | 2017-06-06 | Ut-Battelle, Llc | Phosphonium-based ionic liquids and their use in the capture of polluting gases |
| US10385251B2 (en) | 2013-09-30 | 2019-08-20 | University Of Notre Dame Du Lac | Compounds, complexes, compositions, methods and systems for heating and cooling |
| US10086331B2 (en) | 2013-11-05 | 2018-10-02 | University Of Notre Dame Du Lac | Carbon dioxide capture using phase change ionic liquids |
| JP6803138B2 (ja) * | 2014-10-22 | 2020-12-23 | 三星エスディアイ株式会社Samsung SDI Co., Ltd. | ホスホニウム系化合物、それを含むエポキシ樹脂組成物、およびそれを用いて製造された半導体装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW223059B (es) * | 1991-07-23 | 1994-05-01 | Schering Corp | |
| CZ7696A3 (en) * | 1993-07-09 | 1996-04-17 | Schering Corp | Process for preparing azetidinone |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| CN1217927C (zh) * | 2000-12-21 | 2005-09-07 | 阿文蒂斯药物德国有限公司 | 新的1,2－二苯基氮杂环丁烷酮、其制备方法、含有所述化合物的药物及其在治疗脂质代谢病症中的应用 |
| TWI291957B (en) * | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
-
2005
- 2005-05-20 AR ARP050102099A patent/AR049184A1/es not_active Application Discontinuation
- 2005-05-20 DE DE502005001841T patent/DE502005001841D1/de active Active
- 2005-05-20 TW TW094116483A patent/TW200611896A/zh unknown
- 2005-05-20 WO PCT/EP2005/005498 patent/WO2005113496A1/de active Application Filing
- 2005-05-20 KR KR1020067024431A patent/KR20070027554A/ko not_active Application Discontinuation
- 2005-05-20 EP EP05747892A patent/EP1756049B1/de active Active
- 2005-05-20 AU AU2005245124A patent/AU2005245124A1/en not_active Abandoned
- 2005-05-20 MX MXPA06013456A patent/MXPA06013456A/es active IP Right Grant
- 2005-05-20 PL PL05747892T patent/PL1756049T3/pl unknown
- 2005-05-20 AT AT05747892T patent/ATE376997T1/de not_active IP Right Cessation
- 2005-05-20 ES ES05747892T patent/ES2294712T3/es active Active
- 2005-05-20 RU RU2006145444/04A patent/RU2380361C2/ru not_active IP Right Cessation
- 2005-05-20 RS RSP-2007/0483A patent/RS50539B/sr unknown
- 2005-05-20 UY UY28912A patent/UY28912A1/es unknown
- 2005-05-20 NZ NZ551413A patent/NZ551413A/en unknown
- 2005-05-20 JP JP2007517094A patent/JP2007538042A/ja not_active Abandoned
- 2005-05-20 BR BRPI0510150-6A patent/BRPI0510150A/pt not_active IP Right Cessation
- 2005-05-20 DK DK05747892T patent/DK1756049T3/da active
- 2005-05-20 CA CA002567149A patent/CA2567149A1/en not_active Abandoned
- 2005-05-20 PT PT05747892T patent/PT1756049E/pt unknown
-
2006
- 2006-11-01 IL IL178991A patent/IL178991A0/en unknown
- 2006-11-17 MA MA29462A patent/MA28635B1/fr unknown
- 2006-11-20 US US11/561,626 patent/US7488818B2/en not_active Expired - Fee Related
-
2007
- 2007-07-09 HK HK07107318.3A patent/HK1103296A1/xx not_active IP Right Cessation
- 2007-12-18 HR HR20070570T patent/HRP20070570T3/xx unknown
-
2008
- 2008-01-10 CY CY20081100037T patent/CY1107425T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005245124A1 (en) | 2005-12-01 |
| UY28912A1 (es) | 2005-12-30 |
| MA28635B1 (fr) | 2007-06-01 |
| ES2294712T3 (es) | 2008-04-01 |
| RU2380361C2 (ru) | 2010-01-27 |
| HK1103296A1 (en) | 2007-12-14 |
| KR20070027554A (ko) | 2007-03-09 |
| US7488818B2 (en) | 2009-02-10 |
| BRPI0510150A (pt) | 2007-10-02 |
| DE502005001841D1 (de) | 2007-12-13 |
| CY1107425T1 (el) | 2013-03-13 |
| RS50539B (sr) | 2010-05-07 |
| DK1756049T3 (da) | 2008-02-25 |
| HRP20070570T3 (en) | 2008-01-31 |
| WO2005113496A1 (de) | 2005-12-01 |
| PL1756049T3 (pl) | 2008-02-29 |
| CA2567149A1 (en) | 2005-12-01 |
| ATE376997T1 (de) | 2007-11-15 |
| IL178991A0 (en) | 2007-03-08 |
| PT1756049E (pt) | 2007-12-17 |
| MXPA06013456A (es) | 2007-03-01 |
| RU2006145444A (ru) | 2008-06-27 |
| EP1756049B1 (de) | 2007-10-31 |
| TW200611896A (en) | 2006-04-16 |
| JP2007538042A (ja) | 2007-12-27 |
| EP1756049A1 (de) | 2007-02-28 |
| US20070149776A1 (en) | 2007-06-28 |
| NZ551413A (en) | 2009-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |