AR047552A1 - Sistemas de suministro de farmacos de liberacion sostenida biodegradables - Google Patents
Sistemas de suministro de farmacos de liberacion sostenida biodegradablesInfo
- Publication number
- AR047552A1 AR047552A1 ARP040102251A ARP040102251A AR047552A1 AR 047552 A1 AR047552 A1 AR 047552A1 AR P040102251 A ARP040102251 A AR P040102251A AR P040102251 A ARP040102251 A AR P040102251A AR 047552 A1 AR047552 A1 AR 047552A1
- Authority
- AR
- Argentina
- Prior art keywords
- sustained release
- pharmacos
- supply systems
- systems
- biodegradable sustained
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/121—Solutions, i.e. homogeneous liquid formulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Nanotechnology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sistemas para suministro de fármacos de liberacion sostenida, dispositivos médicos que incorporan dichos sistemas, y métodos para su uso y elaboracion. Los sistemas exhiben dispositivos de suministro de fármacos biodegradables que comprenden composiciones de fluido biocompatible y solido biocompatible, a fin de lograr el suministro de fármaco de liberacion sostenida deseado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48331603P | 2003-06-26 | 2003-06-26 | |
US50194703P | 2003-09-11 | 2003-09-11 | |
US57530704P | 2004-05-28 | 2004-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047552A1 true AR047552A1 (es) | 2006-01-25 |
Family
ID=33556435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102251A AR047552A1 (es) | 2003-06-26 | 2004-06-25 | Sistemas de suministro de farmacos de liberacion sostenida biodegradables |
Country Status (10)
Country | Link |
---|---|
US (2) | US8815284B2 (es) |
EP (1) | EP1635787B1 (es) |
JP (3) | JP5628467B2 (es) |
AR (1) | AR047552A1 (es) |
AT (1) | ATE536861T1 (es) |
CA (1) | CA2530113C (es) |
DK (1) | DK1635787T3 (es) |
ES (1) | ES2379466T3 (es) |
TW (1) | TWI367103B (es) |
WO (1) | WO2005000268A2 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040175410A1 (en) * | 2000-04-26 | 2004-09-09 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors |
US20040208910A1 (en) * | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
WO2006002366A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable ocular devices, methods and systems |
US20060110428A1 (en) | 2004-07-02 | 2006-05-25 | Eugene Dejuan | Methods and devices for the treatment of ocular conditions |
EP1868661A1 (en) * | 2005-04-08 | 2007-12-26 | SurModics, Inc. | Sustained release implants for subretinal delivery |
DK1993559T3 (en) | 2006-02-03 | 2016-10-03 | Opko Renal Llc | Treatment of vitamin D deficiency and MALFUNCTION with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
WO2007113762A2 (en) * | 2006-03-31 | 2007-10-11 | Csir | Bulking of soft tissue |
JP4827626B2 (ja) * | 2006-06-14 | 2011-11-30 | キヤノン株式会社 | 被制御機器、遠隔制御システムおよび遠隔制御システムの制御方法、プログラム |
SI2679228T1 (en) | 2006-06-21 | 2018-06-29 | Opko Ireland Global Holdings, Ltd. | THERAPY WITH THE USE OF VITAMIN D ADDITIONAL FIBER AND HORMON RESISTANCE OF VITAMIN D |
EP2044142A2 (en) * | 2006-06-29 | 2009-04-08 | Medtronic, Inc. | Poly(orthoester) polymers, and methods of making and using same |
SI2148661T1 (sl) | 2007-04-25 | 2013-04-30 | Cytochroma Inc. | Nadzorovano oralno sproščanje sestavkov, ki vsebujejo spojino vitamina D in voskasti naosilec |
DK2148684T3 (da) | 2007-04-25 | 2013-04-22 | Cytochroma Inc | Fremgangsmåde til behandling af vitamin D-insufficiens og -deficiens |
BG66186B1 (bg) * | 2008-01-30 | 2011-12-30 | Сийка ГЕОРГИЕВА | Биологично активна хранителна добавка и метод за получаването и |
ES2593356T3 (es) | 2008-04-02 | 2016-12-07 | Opko Ireland Global Holdings, Ltd. | Métodos, composiciones, usos y kits útiles para la deficiencia de la vitamina D y trastornos relacionados |
US8956642B2 (en) * | 2008-04-18 | 2015-02-17 | Medtronic, Inc. | Bupivacaine formulation in a polyorthoester carrier |
US8475823B2 (en) * | 2008-04-18 | 2013-07-02 | Medtronic, Inc. | Baclofen formulation in a polyorthoester carrier |
US8858983B2 (en) | 2009-04-30 | 2014-10-14 | Medtronic, Inc. | Antioxidants and antimicrobial accessories including antioxidants |
RS60087B1 (sr) | 2010-03-29 | 2020-05-29 | Opko Ireland Global Holdings Ltd | Postupci i kompozicije za snižavanje nivoa paratireoidnog hormona |
US8911427B2 (en) | 2010-12-28 | 2014-12-16 | Medtronic, Inc. | Therapeutic agent reservoir delivery system |
ES2985784T3 (es) | 2011-11-18 | 2024-11-07 | Regeneron Pharma | Micropartículas de proteínas recubiertas con polímeros para formulaciones de liberación prolongada para su uso en el humor vítreo del ojo para tratar trastornos oculares vasculares |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
WO2016094646A1 (en) * | 2014-12-10 | 2016-06-16 | Incept, Llc | Hydrogel drug delivery implants |
MY193964A (en) * | 2015-10-16 | 2022-11-03 | Regeneron Pharma | Stable protein compositions |
EA038755B1 (ru) | 2015-11-12 | 2021-10-14 | Грейбаг Вижн, Инк. | Агрегирующие микрочастицы для обеспечения замедленного высвобождения терапевтического агента для внутриглазной доставки |
US11173168B2 (en) | 2016-03-28 | 2021-11-16 | Eirgen Pharma Ltd. | Methods of treating vitamin D insufficiency in chronic kidney disease |
WO2018175922A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
JP2020519585A (ja) | 2017-05-10 | 2020-07-02 | グレイバグ ビジョン インコーポレイテッド | 医学療法のための延長放出マイクロ粒子及びその懸濁液 |
Family Cites Families (34)
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US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
JPS59110607A (ja) | 1982-12-17 | 1984-06-26 | シ−トン・カンパニ− | 医薬化粧品用軟質連続フイルム |
AU3432689A (en) * | 1988-03-24 | 1989-10-16 | Bukh Meditec A/S | Controlled release composition |
US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
US5110596A (en) | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
IL92966A (en) | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5324280A (en) * | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
US5681964A (en) * | 1990-10-23 | 1997-10-28 | University Of Kentucky Research Foundation | Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents |
US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
BR9507313A (pt) * | 1994-04-08 | 1997-10-07 | Atrix Lab Inc | Composição liquida de liberação adequada para a formação de um implante de liberação controlada sistema polimérico curativo filmico microporoso biodegradável precursor de implante de liberação controlada para a implantação em um indivíduo polímero termoplástico solvente orgánico composicão de pré-polimero liquido componente de liberação controlada agente ativo uso da composição liquida de liberação e processos para forma um implante microporoso de liberação prolongada e para liberar um agente ativo em um individuo |
GB9409281D0 (en) | 1994-05-10 | 1994-06-29 | Svedman Paul | Transdermal device |
WO1996040731A1 (en) * | 1995-06-07 | 1996-12-19 | Mount Sinai School Of Medicine Of The City University Of New York | Pegylated modified proteins |
US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
DE19607395C2 (de) * | 1996-02-28 | 2002-11-21 | Lohmann Therapie Syst Lts | Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate |
PT959873E (pt) | 1996-12-20 | 2006-07-31 | Alza Corp | Composicao de gel e metodos |
US6841617B2 (en) | 2000-09-28 | 2005-01-11 | Battelle Memorial Institute | Thermogelling biodegradable aqueous polymer solution |
HUP0104721A3 (en) | 1998-12-17 | 2006-07-28 | Alza Corp Mountain View | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
NZ515911A (en) * | 1999-06-04 | 2004-02-27 | Alza Corp | Implantable gel compositions and method of manufacture |
KR100416242B1 (ko) * | 1999-12-22 | 2004-01-31 | 주식회사 삼양사 | 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법 |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
CA2413157A1 (en) | 2000-06-28 | 2002-01-03 | Atul J. Shukla | Biodegradable vehicles and delivery systems of biologically active substances |
EP2316490A3 (en) | 2000-10-31 | 2012-02-01 | PR Pharmaceuticals, Inc. | Methods and compositions for enhanced delivery of bioactive molecules |
KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
US20030049320A1 (en) * | 2000-12-18 | 2003-03-13 | Wockhardt Limited | Novel in-situ forming controlled release microcarrier delivery system |
US20060078618A1 (en) * | 2001-12-11 | 2006-04-13 | Constantinides Panayiotis P | Lipid particles and suspensions and uses thereof |
DK1476181T3 (en) | 2002-01-18 | 2016-05-23 | Biogen Ma Inc | POLYALKYLENE POLYMER COMPOUNDS AND USE THEREOF |
US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
JP5305135B2 (ja) | 2008-08-05 | 2013-10-02 | 株式会社リコー | 潤滑剤薄膜化装置、並びに、これを備える画像形成装置及びプロセスカートリッジ |
-
2004
- 2004-06-25 JP JP2006517693A patent/JP5628467B2/ja not_active Expired - Fee Related
- 2004-06-25 AT AT04777134T patent/ATE536861T1/de active
- 2004-06-25 EP EP04777134A patent/EP1635787B1/en not_active Expired - Lifetime
- 2004-06-25 AR ARP040102251A patent/AR047552A1/es not_active Application Discontinuation
- 2004-06-25 WO PCT/US2004/020547 patent/WO2005000268A2/en active Application Filing
- 2004-06-25 TW TW093118702A patent/TWI367103B/zh not_active IP Right Cessation
- 2004-06-25 US US10/877,761 patent/US8815284B2/en active Active
- 2004-06-25 DK DK04777134.0T patent/DK1635787T3/da active
- 2004-06-25 ES ES04777134T patent/ES2379466T3/es not_active Expired - Lifetime
- 2004-06-25 CA CA2530113A patent/CA2530113C/en not_active Expired - Lifetime
-
2011
- 2011-02-16 JP JP2011031239A patent/JP2011093944A/ja active Pending
-
2014
- 2014-07-01 US US14/320,940 patent/US10300114B2/en not_active Expired - Lifetime
- 2014-07-30 JP JP2014155394A patent/JP2014205713A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US8815284B2 (en) | 2014-08-26 |
JP2011093944A (ja) | 2011-05-12 |
DK1635787T3 (da) | 2012-03-26 |
WO2005000268A3 (en) | 2005-08-18 |
EP1635787B1 (en) | 2011-12-14 |
ES2379466T3 (es) | 2012-04-26 |
US20140363482A1 (en) | 2014-12-11 |
TWI367103B (en) | 2012-07-01 |
EP1635787A2 (en) | 2006-03-22 |
CA2530113C (en) | 2013-08-13 |
JP2014205713A (ja) | 2014-10-30 |
US20050025834A1 (en) | 2005-02-03 |
WO2005000268A2 (en) | 2005-01-06 |
TW200515919A (en) | 2005-05-16 |
JP5628467B2 (ja) | 2014-11-19 |
US10300114B2 (en) | 2019-05-28 |
ATE536861T1 (de) | 2011-12-15 |
JP2007537977A (ja) | 2007-12-27 |
CA2530113A1 (en) | 2005-01-06 |
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