AR038762A1 - Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamento - Google Patents
Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamentoInfo
- Publication number
- AR038762A1 AR038762A1 ARP010104806A ARP010104806A AR038762A1 AR 038762 A1 AR038762 A1 AR 038762A1 AR P010104806 A ARP010104806 A AR P010104806A AR P010104806 A ARP010104806 A AR P010104806A AR 038762 A1 AR038762 A1 AR 038762A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- preparation
- ring
- alkynyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Derivados de indolina, que comprenden compuestos de fórmula general (1) en la que R1 y R2 se seleccionan independientemente entre hidrógeno, alquilo, alquenilo, alquinilo, y cicloalquilo; R3 es alquilo, alquenilo, alquinilo, o cicloalquilo; R4, R5, R6 y R7 se seleccionan independientemente entre hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, halógeno, haloalquilo, hidroxi, arilo, amino, mono- y dialquilamino, alcoxi, cicloalquiloxi, ariloxi, heteroariloxi, alquiltio, alquilsulfoxilo, alquilsulfonilo, nitro, ciano, alcoxicarbonilo, ariloxicarbonilo, heteroariloxicarbonilo, heteroarilo, alquilcarbonilamino, arilcarbonilamino, heteroarilcarbonilamino, y carboxilo; el anillo A representa un anillo heterocíclico de 5 a 6 miembros, parcialmente insaturado o saturado, carbocíclico o saturado o parcialmente instaurado, en donde los dos átomos del anillo de indolina al cual el anillo A está fusionado forman un enlace simple C-C saturado; y sales, ésteres y/o sus compuestos de adición farmacéuticamente aceptables. Estos compuestos son especialmente útiles para la prevención y tratamiento de trastornos del sistema nervioso central; dano al sistema nervioso central; trastornos cardiovasculares; trastornos gastrointestinales; diabetes, apnea del sueno y especialmente para el tratamiento y prevención de la obesidad. También se describe un proceso para la preparación de dichos derivados, una composición farmacéutica, un proceso para la preparación de dicha composición y el uso de dichos derivados para la fabricación de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00122539 | 2000-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038762A1 true AR038762A1 (es) | 2005-01-26 |
Family
ID=8170101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104806A AR038762A1 (es) | 2000-10-16 | 2001-10-12 | Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamento |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6479534B1 (es) |
| EP (1) | EP1328515B1 (es) |
| JP (1) | JP4047723B2 (es) |
| KR (1) | KR100545435B1 (es) |
| CN (1) | CN100334076C (es) |
| AR (1) | AR038762A1 (es) |
| AT (1) | ATE403647T1 (es) |
| AU (2) | AU2167002A (es) |
| BR (1) | BR0114708A (es) |
| CA (1) | CA2422698C (es) |
| DE (1) | DE60135239D1 (es) |
| ES (1) | ES2311563T3 (es) |
| MX (1) | MXPA03003246A (es) |
| WO (1) | WO2002044152A1 (es) |
| ZA (1) | ZA200302516B (es) |
Families Citing this family (69)
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| ATE427759T1 (de) | 2004-11-01 | 2009-04-15 | Amylin Pharmaceuticals Inc | Behandlung von fettsucht und verbundenen erkrankungen |
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| CA2666036C (en) | 2008-05-16 | 2017-09-12 | Chien-Hung Chen | Novel compositions and methods for treating hyperproliferative diseases |
| US20110071129A1 (en) | 2008-06-19 | 2011-03-24 | Makoto Ando | Spirodiamine-diaryl ketoxime derivative |
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| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| BR112015002080A2 (pt) | 2012-08-02 | 2017-07-04 | Merck Sharp & Dohme | composto, composição farmacêutica, uso de um composto, e, método de tratamento ou de prevenção de um transtorno, de uma condição ou de uma doença |
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| ES2981866T3 (es) | 2013-06-05 | 2024-10-10 | Bausch Health Ireland Ltd | Agonistas ultrapuros de guanilato ciclasa C, método de elaboración y uso de los mismos |
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| RU2746405C2 (ru) | 2014-08-29 | 2021-04-13 | Тес Фарма С.Р.Л. | ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ-ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ |
| KR20190065312A (ko) | 2016-10-14 | 2019-06-11 | 테스 파마 에스.알.엘. | 알파-아미노-베타-카복시뮤콘산 세미알데하이드 데카복실라제의 저해제 |
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| US11722026B2 (en) | 2019-04-23 | 2023-08-08 | Dpm Technologies Inc. | Fault tolerant rotating electric machine |
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| WO2021263246A1 (en) | 2020-06-27 | 2021-12-30 | Crescenta Biosciences | Novel cell metabolism modulating compounds and uses thereof |
| WO2022040070A1 (en) | 2020-08-18 | 2022-02-24 | Merck Sharp & Dohme Corp. | Bicycloheptane pyrrolidine orexin receptor agonists |
| US11897362B2 (en) | 2021-05-04 | 2024-02-13 | Exro Technologies Inc. | Systems and methods for individual control of a plurality of controllable units of battery cells |
| WO2022236424A1 (en) | 2021-05-13 | 2022-11-17 | Exro Technologies Inc. | Method and appartus to drive coils of a multiphase electric machine |
| US12138243B2 (en) | 2021-12-31 | 2024-11-12 | Crescenta Biosciences | Antiviral use of FABP4 modulating compounds |
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|---|---|---|---|---|
| US2541211A (en) | 1948-10-15 | 1951-02-13 | Searle & Co | Tertiary-aminoalkyl-tetrahydrocarbazoles |
| US2687414A (en) | 1948-11-26 | 1954-08-24 | Searle & Co | Method for producing aromatic aminoalkyl amines |
| DE930988C (de) | 1953-01-01 | 1955-07-28 | Bayer Ag | Verfahren zur Herstellung von basisch alkylierten Tetrahydrocarbazolen oder Indolen |
| US3142678A (en) | 1962-01-09 | 1964-07-28 | American Home Prod | Amino substituted penthienoindoles |
| US3663567A (en) * | 1970-12-04 | 1972-05-16 | Sandoz Ag | N-substituted cycloalkanoindoles |
| GB1418703A (en) * | 1973-06-02 | 1975-12-24 | Pfizer Ltd | 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles |
| GB1432649A (es) | 1973-09-07 | 1976-04-22 | Ici Ltd | |
| CA1247547A (en) | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| CA1328881C (en) | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| CA2035972C (en) | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
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| TW270114B (es) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
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-
2001
- 2001-10-12 CA CA002422698A patent/CA2422698C/en not_active Expired - Fee Related
- 2001-10-12 AR ARP010104806A patent/AR038762A1/es unknown
- 2001-10-12 KR KR1020037005300A patent/KR100545435B1/ko not_active IP Right Cessation
- 2001-10-12 MX MXPA03003246A patent/MXPA03003246A/es active IP Right Grant
- 2001-10-12 AT AT01998144T patent/ATE403647T1/de not_active IP Right Cessation
- 2001-10-12 WO PCT/EP2001/011814 patent/WO2002044152A1/en active IP Right Grant
- 2001-10-12 JP JP2002546522A patent/JP4047723B2/ja not_active Expired - Fee Related
- 2001-10-12 CN CNB018174434A patent/CN100334076C/zh not_active Expired - Fee Related
- 2001-10-12 ES ES01998144T patent/ES2311563T3/es not_active Expired - Lifetime
- 2001-10-12 AU AU2167002A patent/AU2167002A/xx active Pending
- 2001-10-12 AU AU2002221670A patent/AU2002221670B2/en not_active Ceased
- 2001-10-12 EP EP01998144A patent/EP1328515B1/en not_active Expired - Lifetime
- 2001-10-12 DE DE60135239T patent/DE60135239D1/de not_active Expired - Lifetime
- 2001-10-12 BR BR0114708-0A patent/BR0114708A/pt not_active IP Right Cessation
- 2001-10-15 US US09/977,783 patent/US6479534B1/en not_active Expired - Fee Related
-
2003
- 2003-03-31 ZA ZA200302516A patent/ZA200302516B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2422698C (en) | 2009-12-15 |
| MXPA03003246A (es) | 2003-06-06 |
| CA2422698A1 (en) | 2002-06-06 |
| AU2002221670B2 (en) | 2006-11-02 |
| WO2002044152A1 (en) | 2002-06-06 |
| US20020183349A1 (en) | 2002-12-05 |
| ATE403647T1 (de) | 2008-08-15 |
| US6479534B1 (en) | 2002-11-12 |
| JP4047723B2 (ja) | 2008-02-13 |
| BR0114708A (pt) | 2003-07-01 |
| ES2311563T3 (es) | 2009-02-16 |
| DE60135239D1 (de) | 2008-09-18 |
| AU2167002A (en) | 2002-06-11 |
| CN100334076C (zh) | 2007-08-29 |
| JP2004527467A (ja) | 2004-09-09 |
| EP1328515A1 (en) | 2003-07-23 |
| CN1630636A (zh) | 2005-06-22 |
| EP1328515B1 (en) | 2008-08-06 |
| KR100545435B1 (ko) | 2006-01-24 |
| KR20030048437A (ko) | 2003-06-19 |
| ZA200302516B (en) | 2004-06-30 |
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