AR036351A1 - Isoxazolopiridinonas, el uso de las mismas para la fabricacion de un medicamento, composiciones y combinaciones farmaceuticas - Google Patents
Isoxazolopiridinonas, el uso de las mismas para la fabricacion de un medicamento, composiciones y combinaciones farmaceuticasInfo
- Publication number
- AR036351A1 AR036351A1 ARP020103046A ARP020103046A AR036351A1 AR 036351 A1 AR036351 A1 AR 036351A1 AR P020103046 A ARP020103046 A AR P020103046A AR P020103046 A ARP020103046 A AR P020103046A AR 036351 A1 AR036351 A1 AR 036351A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- dialkyl
- alkoxy
- hydrogen
- hydroxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
El uso de isoxazolopiridinonas de la fórmula (1), en donde: X es O, e Y es N, o bien X es N e Y es O; R1 es hidrógeno, alquilo C1-4, cicloalquilo C3-7, cicloalquilo C3-7-alquilo C1-4, o dialquilo C1-4-aminoalquilo C1-4; R2 es alquilo C1-4, cicloalquilo C3-7, benzo[1,3]dioxol-5-ilo, benzo[1,2,5]oxadiazol-5-ilo, benzo[1,2,5]tiadiazol-5-ilo, o un grupo de la fórmula (2) en donde Z es CH o N; R4 es hidrógeno, alquilo C1-4, alcoxilo C1-4, halógeno, hidroxilo, trifluorometilo, dialquilo C1-4-amino, alquilo C1-4-amino, dialquilo C1-4-aminoalquilo C1-4, alquilo C1-4-aminoalquilo C1-4, dialquilo C1-4-aminoalcoxilo C1-4, alquilo C1-4-aminoalcoxilo C1-4, dialquilo C1-4-aminoalcoxilo C1-4-alquilo C1-4, alquilo C1-4-aminoalcoxilo C1-4-alquilo C1-4, di-(alcoxilo C1-4-alquilo C1-4)amino, di-(alcoxilo C1-4-alquilo C1-4)aminoalquilo C1-4, fenilo, fenoxilo, benciloxilo, alquilo C1-4, alcoxilo C1-4-alquilo C1-4, alcoxilo C1-4-alcoxilo C1-4-alquilo C1-4, hidroxialquilo C1-4, CHO, carboxilo, alcoxilo C1-4-carbonilo, morfolinometilo, 4-alquilo C1-4-piperazinilmetilo, piperazinilmetilo, tetrazol-1-ilmetilo, 1-pirrolilmetilo, 3-(dialquilo C1-4-amino)-2-hidroxi-propoxi-alquilo C1-4, 3-(dialquilo C1-4-amino)-2-hidroxipropoxilo, 3-(alquilo C1-4-amino)-2-hidroxi-propoxi-alquilo C1-4, 3-alquilo C1-4-amino-2-hidroxi-propoxilo, 2-hidroxi-3-imidazol-1-il-propoxi-alquilo C1-4, 2-hidroxi-3-imidazol-1-il-propoxilo, 2-hidroxi-3-morfolin-4-il-propoxilo, 2-hidroxi-3-morfolin-4-il-propoxi-alquilo C1-4, y R5 y R6 son independientemente, hidrógeno, halógeno, hidroxilo, alquilo C1-4, o alcoxilo C1-4, y R3 es hidrógeno, halógeno, alquilo C1-4, dialquilo C1-4-aminoalquilo C1-4, dialquilo C1-4-aminoalcoxilo C1-4, alquilo C1-4-aminoalquilo C1-4, alquilo C1-4-aminoalcoxilo C1-4, o alcoxilo C1-4, en forma de base libre o de sal de adición de ácido farmacéuticamente aceptable, para la fabricación de un medicamento para el tratamiento de la enfermedad de Parkinson. Un compuesto de la fórmula (1), en donde X, Y, R1, R2 y R3 son como se definen en la reivindicación 1, en el entendido de que: i) cuando X es N, Y es O, R2 es fenilo insustituido y R3 es hidrógeno, entonces R1 es diferente de hidrógeno, y ii) cuando X es N, Y es O, R2, es un grupo de la fórmula (2) en donde Z es N y R4 es hidrógeno, o bien Z es CH y R4 es hidrógeno, metilo, metoxilo, halógeno, trifluorometilo, p-bromometilo, p-benciloxilo, dimetilaminometilo, metilaminometilo, 4-alquilo C1-4-piperazinimetilo, piperidinometilo o morfolinometilo, y R3 es hidrógeno, cloro, flúor, metilo, trifluorometilo, o alcoxilo C1-4 , entonces R1 es diferente de metilo, en forma de base libre o de sal de adición. Los compuestos de la fórmula (1) son útiles como productos farmacéuticos. También se describen composiciones y combinaciones farmacéuticas y el uso de dichos compuestos para la fabricación de un medicamento para el tratamiento de la enfermedad de Parkinson.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119911.6A GB0119911D0 (en) | 2001-08-15 | 2001-08-15 | Organic Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036351A1 true AR036351A1 (es) | 2004-09-01 |
Family
ID=9920454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103046A AR036351A1 (es) | 2001-08-15 | 2002-08-13 | Isoxazolopiridinonas, el uso de las mismas para la fabricacion de un medicamento, composiciones y combinaciones farmaceuticas |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7087756B2 (es) |
| EP (1) | EP1418912B1 (es) |
| JP (1) | JP2005501847A (es) |
| KR (1) | KR20040029429A (es) |
| CN (1) | CN100384418C (es) |
| AR (1) | AR036351A1 (es) |
| AT (1) | ATE355059T1 (es) |
| BR (1) | BR0211903A (es) |
| CA (1) | CA2454762A1 (es) |
| CO (1) | CO5560566A2 (es) |
| DE (1) | DE60218484T2 (es) |
| EC (1) | ECSP044971A (es) |
| ES (1) | ES2282467T3 (es) |
| GB (1) | GB0119911D0 (es) |
| HU (1) | HUP0401325A3 (es) |
| IL (1) | IL160018A0 (es) |
| MX (1) | MXPA04001419A (es) |
| NO (1) | NO20040659D0 (es) |
| PE (1) | PE20030356A1 (es) |
| PL (1) | PL366848A1 (es) |
| PT (1) | PT1418912E (es) |
| RU (1) | RU2004107847A (es) |
| WO (1) | WO2003015780A2 (es) |
| ZA (1) | ZA200400525B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002102807A1 (ja) * | 2001-06-14 | 2004-09-30 | 萬有製薬株式会社 | 新規イソキサゾロピリドン誘導体及びその用途 |
| EP1745027A4 (en) * | 2004-05-14 | 2009-06-03 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS |
| US8114892B2 (en) * | 2006-02-16 | 2012-02-14 | The Mclean Hospital Corporation | Methods and compositions for the treatment of Parkinson's Disease |
| AU2007275301A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| FR2933609B1 (fr) * | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
| CA2749585A1 (en) | 2009-01-13 | 2010-07-22 | Van Andel Research Institute | Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids |
| FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| FR2955110A1 (fr) | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | Nouveaux derives de type pyrrolopyridine benzoique |
| DE102011085038A1 (de) | 2011-10-21 | 2013-04-25 | Tesa Se | Verfahren zur Kapselung einer elektronischen Anordnung |
| ES2751457T3 (es) | 2013-09-25 | 2020-03-31 | Van Andel Res Institute | Glucocorticoides altamente potentes |
| KR20170033630A (ko) | 2015-09-17 | 2017-03-27 | (주)다올 | 도로용 경계블럭 |
| RU2019111101A (ru) | 2016-10-14 | 2020-11-16 | Ван Андель Рисерч Инститьют | Структуры и механизм для дизайна высокоактивных глюкокортикоидов |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7602542L (sv) | 1975-03-14 | 1976-09-15 | Sandoz Ag | 3-(alfa-iminobensyl)-4-hydroxi-2(lh)-pyridoner |
| US4064251A (en) | 1976-06-25 | 1977-12-20 | Sandoz, Inc. | Substituted hydroxy pyridones |
| US4049813A (en) | 1976-07-15 | 1977-09-20 | Sandoz, Inc. | Substituted isoxazolo pyridinones |
| DE2801190A1 (de) | 1977-01-19 | 1978-07-20 | Sandoz Ag | 3-(alpha-iminobenzyl)-4-hydroxy-2(1h)- pyridon-derivat |
| US4238616A (en) | 1977-01-19 | 1980-12-09 | Sandoz, Inc. | 3-(Substituted)phenyl-5-(β-hydroxyphenethyl)-N-(alkyl)-isoxazole-4-carboxamides |
| US4113727A (en) * | 1977-04-26 | 1978-09-12 | Sandoz, Inc. | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones |
| JPWO2002102807A1 (ja) * | 2001-06-14 | 2004-09-30 | 萬有製薬株式会社 | 新規イソキサゾロピリドン誘導体及びその用途 |
-
2001
- 2001-08-15 GB GBGB0119911.6A patent/GB0119911D0/en not_active Ceased
-
2002
- 2002-08-13 AR ARP020103046A patent/AR036351A1/es unknown
- 2002-08-14 KR KR10-2004-7002124A patent/KR20040029429A/ko not_active Application Discontinuation
- 2002-08-14 PE PE2002000734A patent/PE20030356A1/es not_active Application Discontinuation
- 2002-08-14 CN CNB028159268A patent/CN100384418C/zh not_active Expired - Fee Related
- 2002-08-14 BR BR0211903-0A patent/BR0211903A/pt not_active IP Right Cessation
- 2002-08-14 CA CA002454762A patent/CA2454762A1/en not_active Abandoned
- 2002-08-14 PL PL02366848A patent/PL366848A1/xx not_active Application Discontinuation
- 2002-08-14 PT PT02772157T patent/PT1418912E/pt unknown
- 2002-08-14 AT AT02772157T patent/ATE355059T1/de not_active IP Right Cessation
- 2002-08-14 EP EP02772157A patent/EP1418912B1/en not_active Expired - Lifetime
- 2002-08-14 RU RU2004107847/15A patent/RU2004107847A/ru not_active Application Discontinuation
- 2002-08-14 WO PCT/EP2002/009134 patent/WO2003015780A2/en active IP Right Grant
- 2002-08-14 IL IL16001802A patent/IL160018A0/xx unknown
- 2002-08-14 HU HU0401325A patent/HUP0401325A3/hu unknown
- 2002-08-14 ES ES02772157T patent/ES2282467T3/es not_active Expired - Lifetime
- 2002-08-14 JP JP2003520739A patent/JP2005501847A/ja not_active Withdrawn
- 2002-08-14 DE DE60218484T patent/DE60218484T2/de not_active Expired - Lifetime
- 2002-08-14 US US10/486,569 patent/US7087756B2/en not_active Expired - Fee Related
- 2002-08-14 MX MXPA04001419A patent/MXPA04001419A/es unknown
-
2004
- 2004-01-23 ZA ZA200400525A patent/ZA200400525B/en unknown
- 2004-02-03 EC EC2004004971A patent/ECSP044971A/es unknown
- 2004-02-13 NO NO20040659A patent/NO20040659D0/no not_active Application Discontinuation
- 2004-03-12 CO CO04023011A patent/CO5560566A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1635889A (zh) | 2005-07-06 |
| HUP0401325A3 (en) | 2005-09-28 |
| BR0211903A (pt) | 2004-09-21 |
| CN100384418C (zh) | 2008-04-30 |
| EP1418912B1 (en) | 2007-02-28 |
| ZA200400525B (en) | 2005-04-01 |
| JP2005501847A (ja) | 2005-01-20 |
| HUP0401325A2 (hu) | 2004-10-28 |
| CA2454762A1 (en) | 2003-02-27 |
| GB0119911D0 (en) | 2001-10-10 |
| KR20040029429A (ko) | 2004-04-06 |
| WO2003015780A8 (en) | 2004-05-21 |
| US7087756B2 (en) | 2006-08-08 |
| DE60218484D1 (de) | 2007-04-12 |
| ECSP044971A (es) | 2004-03-23 |
| PT1418912E (pt) | 2007-05-31 |
| PE20030356A1 (es) | 2003-05-14 |
| NO20040659L (no) | 2004-02-13 |
| US20040248893A1 (en) | 2004-12-09 |
| ES2282467T3 (es) | 2007-10-16 |
| PL366848A1 (en) | 2005-02-07 |
| ATE355059T1 (de) | 2006-03-15 |
| EP1418912A2 (en) | 2004-05-19 |
| WO2003015780A2 (en) | 2003-02-27 |
| IL160018A0 (en) | 2004-06-20 |
| DE60218484T2 (de) | 2007-11-15 |
| NO20040659D0 (no) | 2004-02-13 |
| CO5560566A2 (es) | 2005-09-30 |
| WO2003015780A3 (en) | 2003-11-13 |
| MXPA04001419A (es) | 2004-05-27 |
| RU2004107847A (ru) | 2005-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |