AR035809A1 - Cromosomas artificiales que comprenden secuencias de ehv - Google Patents
Cromosomas artificiales que comprenden secuencias de ehvInfo
- Publication number
- AR035809A1 AR035809A1 ARP020101221A AR035809A1 AR 035809 A1 AR035809 A1 AR 035809A1 AR P020101221 A ARP020101221 A AR P020101221A AR 035809 A1 AR035809 A1 AR 035809A1
- Authority
- AR
- Argentina
- Prior art keywords
- ehv
- generation
- virus
- artificial chromosome
- chromosome vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Suspension/Interruption
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16741—Use of virus, viral particle or viral elements as a vector
- C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La invención pertenece al campo de la salud animal, en particular de las enfermedades equinas causadas por el herpesvirus equino (EHV). Se describen los cromosomas artificiales que comprenden esencialmente el genoma completo de una cepa de EHV, en particular, de EHV-1 o EHV-4, siendo RacH la cepa particularmente preferida. Puede introducirse cualquier tipo de mutación en el genoma EHV para obtener un virus EHV deficiente de replicación y/o atenuado. Dichas mutaciones incluyen, pero sin limitación, cualquier mutación (por ejemplo, por deleción, inseción, sustitución) relativa a las glucoproteínas gB, gC, gD, dE, gG, gI, gJ, gL, gM, gp1/2 y cualquier combinación de estas. También se describen las siguientes realizaciones importantes del presente invento: un de polinucleótido que codifica un vector cromosoma artificial o EHV contenido en éste; el uso de un vector cromosoma artificial o de un polinucleótido como el descripto más arriba para la generación de EHV infeccioso; un método para la generación de EHV replicante, en el que se utiliza un vector cromosoma artificial como el descrito más arriba para infectar una estirpe celular adecuada, y se recoge y purifica el virus difundido; un método para la generación de un EHV atenuado y un método para la clonación y generación de un EHV atenuado, en los cuales la secuencia de EHV contenida en un vector cromosoma artificial como el descripto más arriba está específicamente modificada por técnicas de biología molecular; el EHV que puede obtenerse mediante los citados métodos; una composición farmacéutica que comprende un polinucleótido o un virus EHV como el descrito más arriba, junto con vehículos y/o excipientes farmacéuticamente aceptables; uso de un virus EHV, obtenido mediante uno de los citados métodos, en la fabricación de una vacuna para la prevención y/o el tratamiento de infecciones por EHV.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2001116594 DE10116594A1 (de) | 2001-04-03 | 2001-04-03 | Künstliche Chromosomen, die EHV-Sequenzen umfassen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035809A1 true AR035809A1 (es) | 2004-07-14 |
Family
ID=7680223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101221 Suspension/Interruption AR035809A1 (es) | 2001-04-03 | 2002-04-03 | Cromosomas artificiales que comprenden secuencias de ehv |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1377668A2 (es) |
| JP (1) | JP2004531254A (es) |
| AR (1) | AR035809A1 (es) |
| CA (1) | CA2443039A1 (es) |
| DE (1) | DE10116594A1 (es) |
| MX (1) | MXPA03008971A (es) |
| WO (1) | WO2002081712A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080226677A1 (en) | 2004-05-06 | 2008-09-18 | Yasuko Mori | Recombinant virus vector for gene transfer into lymphoid cells |
| ES2711878T3 (es) * | 2012-03-20 | 2019-05-08 | Merial Inc | Vacuna contra el virus del herpes equino 1 recombinante que contiene glicoproteína C mutada y usos de la misma |
| EA201990711A1 (ru) * | 2016-09-20 | 2019-09-30 | Бёрингер Ингельхайм Ветмедика Гмбх | Новый ehv сайт инсерции orf70 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6193983B1 (en) * | 1992-06-01 | 2001-02-27 | The University Of Melbourne | Equine herpesvirus glycoproteins |
-
2001
- 2001-04-03 DE DE2001116594 patent/DE10116594A1/de not_active Withdrawn
-
2002
- 2002-03-30 WO PCT/EP2002/003575 patent/WO2002081712A2/en not_active Application Discontinuation
- 2002-03-30 CA CA002443039A patent/CA2443039A1/en not_active Abandoned
- 2002-03-30 JP JP2002580075A patent/JP2004531254A/ja active Pending
- 2002-03-30 EP EP02727508A patent/EP1377668A2/en not_active Withdrawn
- 2002-03-30 MX MXPA03008971A patent/MXPA03008971A/es unknown
- 2002-04-03 AR ARP020101221 patent/AR035809A1/es not_active Suspension/Interruption
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004531254A (ja) | 2004-10-14 |
| WO2002081712A2 (en) | 2002-10-17 |
| MXPA03008971A (es) | 2004-02-12 |
| EP1377668A2 (en) | 2004-01-07 |
| WO2002081712A3 (en) | 2003-10-02 |
| DE10116594A1 (de) | 2002-10-10 |
| CA2443039A1 (en) | 2002-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |