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AR034203A1 - Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento - Google Patents

Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento

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Publication number
AR034203A1
AR034203A1 ARP020100210A ARP020100210A AR034203A1 AR 034203 A1 AR034203 A1 AR 034203A1 AR P020100210 A ARP020100210 A AR P020100210A AR P020100210 A ARP020100210 A AR P020100210A AR 034203 A1 AR034203 A1 AR 034203A1
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
aryl
independently
heteroaryl group
Prior art date
Application number
ARP020100210A
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English (en)
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Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR034203A1 publication Critical patent/AR034203A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Bioinformatics & Cheminformatics (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Derivados de 1-aril- ó 1-alquilsulfonilbenzazol, que comprenden un compuesto de fórmula (1), en donde: W es SO2, CO, CONH, CSNH ó CH2; X es CR7 ó N; Y es CR8 ó N, con la condición que cuando X es N, entonces Y debe ser CR8; Z es O, SOp ó NR9; R1 y R2 son cada uno de manera independiente H o alquilo C1-6; n es un entero de 2, 3, ó 4; R3 y R4 son cada uno de manera independiente H, CNR10NR11R12 o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido, o R3 y R4 pueden tomarse junto con el átomo al cual están unidos, para formar un anillo de 3 a 6 miembros, opcionalmente sustituido, que contiene opcionalmente un heteroátomo adicional seleccionado entre O, N ó S; R5 es H, halógeno, CN, OR13, CO2R14, CONR15R16, CNR17NR18R19, SO2NR20R21, SOpR22, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, fenilo o heteroarilo, cada uno opcionalmente sustituido; m es un entero de 1, 2, ó 3; p y q son cada uno de manera independiente 0 ó un entero de 1 ó 2; R6 es un grupo alquilo C1-6 opcionalmente sustituido, arilo o heteroarilo; R7 y R8 son cada uno de manera independiente H, halógeno, o un grupo alquilo C1-6, arilo, heteroarilo, o alcoxi C1-6, cada uno opcionalmente sustituido; R9 es H, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloheteroalquilo, arilo o heteroarilo, cada uno opcionalmente sustituido; R10, R11, R12, R15, R16, R17, R18 y R19 son cada uno de manera independiente H, o alquilo C1-4; R13 es H, COR23, o un grupo alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo o heteroarilo, cada uno opcionalmente sustituido; R14 es H, o un grupo alquilo C1-6, arilo o heteroarilo, cada uno opcionalmente sustituido; R20 y R21 son cada uno de manera independiente H o un grupo alquilo C1-6, arilo o heteroarilo, cada uno opcionalmente sustituido; y R22 y R23 son cada uno de manera independiente un grupo alquilo C1-6 opcionalmente sustituido, arilo o heteroarilo; o una sal farmacéuticamente aceptable del mismo; un método para su preparación, una composición farmacéutica y el uso del mismo para el tratamiento terapéutico de desórdenes relacionados con, o afectados por el receptor de 5-HT6.
ARP020100210A 2001-01-23 2002-01-22 Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento AR034203A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26342501P 2001-01-23 2001-01-23

Publications (1)

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AR034203A1 true AR034203A1 (es) 2004-02-04

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ARP020100210A AR034203A1 (es) 2001-01-23 2002-01-22 Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento

Country Status (23)

Country Link
US (4) US6509357B1 (es)
EP (1) EP1353904B9 (es)
JP (1) JP4208573B2 (es)
KR (1) KR20030068591A (es)
CN (1) CN1273450C (es)
AR (1) AR034203A1 (es)
AT (1) ATE312078T1 (es)
AU (1) AU2002251811B2 (es)
BR (1) BR0206633A (es)
CA (1) CA2435566A1 (es)
DE (1) DE60207815T2 (es)
DK (1) DK1353904T3 (es)
EA (1) EA006057B1 (es)
ES (1) ES2250638T3 (es)
HU (1) HUP0401009A3 (es)
IL (1) IL157059A0 (es)
MX (1) MXPA03006479A (es)
NO (1) NO20033300L (es)
NZ (1) NZ527051A (es)
PL (1) PL364568A1 (es)
TW (1) TW593278B (es)
WO (1) WO2002059088A1 (es)
ZA (1) ZA200306542B (es)

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DE60207815T2 (de) 2006-08-24
DK1353904T3 (da) 2006-02-20
DE60207815D1 (de) 2006-01-12
AU2002251811B2 (en) 2007-06-21
ES2250638T3 (es) 2006-04-16
WO2002059088A1 (en) 2002-08-01
HUP0401009A3 (en) 2004-10-28
US6710069B2 (en) 2004-03-23
TW593278B (en) 2004-06-21
US20040092564A1 (en) 2004-05-13
JP2004521116A (ja) 2004-07-15
ATE312078T1 (de) 2005-12-15
KR20030068591A (ko) 2003-08-21
US6509357B1 (en) 2003-01-21
EP1353904B1 (en) 2005-12-07
HUP0401009A2 (hu) 2004-08-30
US6919354B2 (en) 2005-07-19
IL157059A0 (en) 2004-02-08
MXPA03006479A (es) 2003-09-22
EA200300829A1 (ru) 2003-12-25
BR0206633A (pt) 2004-02-17
US20030149018A1 (en) 2003-08-07
CN1273450C (zh) 2006-09-06
US20040087637A1 (en) 2004-05-06
NZ527051A (en) 2005-07-29
EP1353904A1 (en) 2003-10-22
CN1498209A (zh) 2004-05-19
ZA200306542B (en) 2005-11-21
NO20033300D0 (no) 2003-07-22
JP4208573B2 (ja) 2009-01-14
EP1353904B9 (en) 2006-05-03
PL364568A1 (en) 2004-12-13
CA2435566A1 (en) 2002-08-01
NO20033300L (no) 2003-09-03
EA006057B1 (ru) 2005-08-25

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