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AR033377A1 - Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos - Google Patents

Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos

Info

Publication number
AR033377A1
AR033377A1 ARP010102492A ARP010102492A AR033377A1 AR 033377 A1 AR033377 A1 AR 033377A1 AR P010102492 A ARP010102492 A AR P010102492A AR P010102492 A ARP010102492 A AR P010102492A AR 033377 A1 AR033377 A1 AR 033377A1
Authority
AR
Argentina
Prior art keywords
antagonists
benzocicloalquilenilamina
derivatives
muscarinic receptors
compounds
Prior art date
Application number
ARP010102492A
Other languages
English (en)
Inventor
Russell Stephen Stabler
Robert James Weikert
Ann Marie Madera
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR033377A1 publication Critical patent/AR033377A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
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    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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    • C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Organic Chemistry (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos que son en general antagonistas de receptores muscarínicos M2/M3 y que pueden representarse por la formula (1) en la que X, Y y Z son -O-, -S- o >N-R4 y los demás sustituyentes tienen los significados definidos en la especificacion; o "profármacos"; isomeros individuales, mezclas racémicas o no racémicas de isomeros, y sales farmacéuticamente aceptables o solvatos de los mismos. Composiciones farmacéuticas que contienen tales compuestos, un proceso para su obtencion y su utilizacion para el tratamiento de enfermedades asociadas con trastornos del musculo liso.
ARP010102492A 2000-05-25 2001-05-24 Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos AR033377A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20748300P 2000-05-25 2000-05-25
US26761701P 2001-02-09 2001-02-09

Publications (1)

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AR033377A1 true AR033377A1 (es) 2003-12-17

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ARP010102492A AR033377A1 (es) 2000-05-25 2001-05-24 Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos

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US (3) US6500822B2 (es)
EP (1) EP1289964B1 (es)
JP (1) JP3955211B2 (es)
KR (1) KR100599125B1 (es)
CN (1) CN1187342C (es)
AR (1) AR033377A1 (es)
AT (1) ATE280162T1 (es)
AU (2) AU2001260310B2 (es)
BR (1) BR0111019A (es)
CA (1) CA2408934C (es)
CZ (1) CZ20024199A3 (es)
DE (1) DE60106607T2 (es)
ES (1) ES2230310T3 (es)
HU (1) HUP0302015A2 (es)
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CZ20024199A3 (cs) 2004-01-14
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KR100599125B1 (ko) 2006-07-12
BR0111019A (pt) 2003-06-17
US6645958B2 (en) 2003-11-11
PL361361A1 (en) 2004-10-04
NO20025641L (no) 2002-12-17
PE20011258A1 (es) 2001-12-11
AU6031001A (en) 2001-12-03
ATE280162T1 (de) 2004-11-15
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US20040034018A1 (en) 2004-02-19
DE60106607T2 (de) 2006-02-09
AU2001260310B2 (en) 2007-04-05
US20030109524A1 (en) 2003-06-12
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US20020004494A1 (en) 2002-01-10
DE60106607D1 (de) 2004-11-25
US6818645B2 (en) 2004-11-16
IL152700A0 (en) 2003-06-24
KR20030003758A (ko) 2003-01-10
RU2243222C2 (ru) 2004-12-27
CA2408934C (en) 2009-04-14
WO2001090082A1 (en) 2001-11-29
JP2003534331A (ja) 2003-11-18
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YU89002A (sh) 2006-01-16
MXPA02011417A (es) 2003-04-25
CN1187342C (zh) 2005-02-02
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