AR032920A1 - Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores - Google Patents
Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidoresInfo
- Publication number
- AR032920A1 AR032920A1 ARP020100730A ARP020100730A AR032920A1 AR 032920 A1 AR032920 A1 AR 032920A1 AR P020100730 A ARP020100730 A AR P020100730A AR P020100730 A ARP020100730 A AR P020100730A AR 032920 A1 AR032920 A1 AR 032920A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- substituted
- alkoxy
- halogen
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se proporcionan nuevos inhibidores de PDF y nuevos métodos para su uso. Dichos inhibidores responden a la formula (1) donde X= O, NR3 o un enlace; Y= O, CH2 o un enlace; R representa alquilo C2-6 (opcionalmente sustituido con alcoxi, halogeno o alquilsulfanilo C1-3), alquenilo C2-6 (opcionalmente sustituido con alcoxi, halogeno o alquilsulfanilo C1-3), alquinilo C2-6 (opcionalmente sustituido con alcoxi, halogeno o alquilsulfanilo C1-3), (CH2)n-carbocilo C3-6 (opcionalmente sustituido con alcoxi, halogeno o alquilsulfanilo C1-3, (CH2)n-R4 {en donde R4 es fenilo, furano, benzofurano, tiofeno, benzotiofeno, tetrahidrofurano, tetrahidropirano, dioxano, 1,4-benzodioxano o benzo[1,3]dioxol; R4 está opcionalmente sustituido con uno o más Cl, Br, I, alquilo C1-3 (opcionalmente sustituido con uno a tres F) o alcoxi C1-2 (opcionalmente sustituido con uno a tres F); R1 representa: hidrogeno, alquilo C1-6 (opcionalmente sustituido con hidroxi, halogeno, amino, guanidino, fenilo, piridilo, pirrolilo, indolilo, imidazolilo, furanilo, benzofuranilo, piperidinilo, morfolinilo, quinolinilo, piperazinilo o dImitilaminofenilo) o (CH2)n-carbociclo C3-7; R2 representa: hidrogeno (con la condicion de que X no es O), alquilo C1-3 sustituido, alquenilo C2-3 sustituido, alquinilo C2-3 sustituido (CH2)n-carbociclo C3-6 sustituido, arilo, heteroarilo, heterocíclico, carboxi (con la condicion de que X no es NR3 ni O) o aminocarbonilo (con la condicion de que X no es NR3 ni O); R3 representa: hidrogeno, alquilo C1-3 sustituido, fenilo o se puede tomar conjuntamente con R2 y el átomo de nitrogeno al que están unidos para formar un anillo heterocíclico opcionalmente sustituido que está opcionalmente condensado a un anillo de arilo, heteroarilo o un segundo heterocíclico; X representa O, NR3 o un enlace covalente; Y representa O, CH2 o un enlace covalente; n=0-2; o una sal, solvato o derivado fisiologicamente funcional del mismo. También se describen y reivindican medios que incluyen inhibidores aplicables en el tratamiento de infecciones bacterianas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27257001P | 2001-03-01 | 2001-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032920A1 true AR032920A1 (es) | 2003-12-03 |
Family
ID=23040368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100730A AR032920A1 (es) | 2001-03-01 | 2002-02-28 | Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7019003B2 (es) |
| EP (1) | EP1363873B1 (es) |
| JP (1) | JP4266638B2 (es) |
| KR (1) | KR20030092008A (es) |
| CN (1) | CN1505607A (es) |
| AR (1) | AR032920A1 (es) |
| AU (1) | AU2002335490B2 (es) |
| BR (1) | BR0207810A (es) |
| CA (1) | CA2439827A1 (es) |
| CZ (1) | CZ20032342A3 (es) |
| EG (1) | EG24516A (es) |
| HU (1) | HUP0303308A2 (es) |
| IL (1) | IL157643A0 (es) |
| MX (1) | MXPA03007869A (es) |
| NO (1) | NO20033828L (es) |
| NZ (1) | NZ527728A (es) |
| PE (1) | PE20020906A1 (es) |
| PL (1) | PL364563A1 (es) |
| UY (1) | UY27192A1 (es) |
| WO (1) | WO2002070541A2 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY27813A1 (es) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
| JP2005532358A (ja) * | 2002-06-06 | 2005-10-27 | スミスクライン・ビーチャム・コーポレイション | ペプチドデホルミラーゼ阻害剤 |
| PT1542968E (pt) | 2002-09-19 | 2009-03-25 | Novartis Ag | Processo para preparar intermediários |
| GB0229673D0 (en) * | 2002-12-19 | 2003-01-29 | British Biotech Pharm | Antibacterial agents |
| US7332485B2 (en) * | 2003-07-08 | 2008-02-19 | Smithkline Beecham Corp | Peptide deformylase inhibitors |
| EP1654239A4 (en) * | 2003-08-15 | 2008-10-01 | Smithkline Beecham Corp | PEPTIDE deformylase INHIBITORS |
| JP2008520686A (ja) * | 2004-11-17 | 2008-06-19 | スミスクライン・ビーチャム・コーポレイション | 新規な抗菌化合物の使用 |
| JP5199087B2 (ja) * | 2005-07-29 | 2013-05-15 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | ペプチドデホルミラーゼ阻害剤 |
| US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
| EA200801128A1 (ru) * | 2005-10-21 | 2008-10-30 | Глэксо Груп Лимитед | Пери-конденсированные трициклические соединения, полезные в качестве антибактериальных средств |
| KR100753796B1 (ko) * | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
| GB0707706D0 (en) * | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
| CA2730890C (en) | 2008-07-17 | 2018-05-15 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| CA2794952C (en) | 2010-04-01 | 2018-05-15 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| BR112014013287A2 (pt) * | 2011-12-02 | 2017-06-13 | Glaxosmithkline Intellectual Property (No 2) Ltd | inibidores de peptídeo deformilase |
| CN116375698B (zh) * | 2023-06-05 | 2023-08-01 | 中国林业科学研究院林产化学工业研究所 | 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| US6013792A (en) * | 1993-08-05 | 2000-01-11 | Syntex (U.S.A.), Inc. | Matrix metalloprotease inhibitors |
| US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
| ATE181055T1 (de) * | 1994-05-28 | 1999-06-15 | British Biotech Pharm | Succinyl hydroxamsäure-, n-formyl-n-hydroxy- aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease- inhibitoren |
| GB9827805D0 (en) * | 1998-12-16 | 1999-02-10 | British Biotech Pharm | Antibacterial agents |
| EP1242581A2 (en) | 1999-12-08 | 2002-09-25 | Bayer Aktiengesellschaft | Regulation of human mitochondrial deformylase |
-
2002
- 2002-02-28 UY UY27192A patent/UY27192A1/es not_active Application Discontinuation
- 2002-02-28 AR ARP020100730A patent/AR032920A1/es not_active Application Discontinuation
- 2002-03-01 CA CA002439827A patent/CA2439827A1/en not_active Abandoned
- 2002-03-01 NZ NZ527728A patent/NZ527728A/en not_active IP Right Cessation
- 2002-03-01 JP JP2002569860A patent/JP4266638B2/ja not_active Expired - Fee Related
- 2002-03-01 PE PE2002000170A patent/PE20020906A1/es not_active Application Discontinuation
- 2002-03-01 KR KR10-2003-7011370A patent/KR20030092008A/ko not_active Application Discontinuation
- 2002-03-01 PL PL02364563A patent/PL364563A1/xx not_active Application Discontinuation
- 2002-03-01 CN CNA028092570A patent/CN1505607A/zh active Pending
- 2002-03-01 US US10/469,433 patent/US7019003B2/en not_active Expired - Fee Related
- 2002-03-01 HU HU0303308A patent/HUP0303308A2/hu unknown
- 2002-03-01 WO PCT/US2002/006275 patent/WO2002070541A2/en active IP Right Grant
- 2002-03-01 CZ CZ20032342A patent/CZ20032342A3/cs unknown
- 2002-03-01 MX MXPA03007869A patent/MXPA03007869A/es not_active Application Discontinuation
- 2002-03-01 BR BRPI0207810-4A patent/BR0207810A/pt not_active IP Right Cessation
- 2002-03-01 EP EP02748375.9A patent/EP1363873B1/en not_active Expired - Lifetime
- 2002-03-01 IL IL15764302A patent/IL157643A0/xx unknown
- 2002-03-01 AU AU2002335490A patent/AU2002335490B2/en not_active Ceased
-
2003
- 2003-05-20 EG EG2003050473A patent/EG24516A/xx active
- 2003-08-28 NO NO20033828A patent/NO20033828L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1363873B1 (en) | 2016-04-20 |
| EG24516A (en) | 2009-08-19 |
| NO20033828D0 (no) | 2003-08-28 |
| MXPA03007869A (es) | 2003-12-04 |
| EP1363873A4 (en) | 2006-01-04 |
| EP1363873A2 (en) | 2003-11-26 |
| PL364563A1 (en) | 2004-12-13 |
| US20040087585A1 (en) | 2004-05-06 |
| JP4266638B2 (ja) | 2009-05-20 |
| HUP0303308A2 (hu) | 2004-01-28 |
| NZ527728A (en) | 2004-09-24 |
| NO20033828L (no) | 2003-10-06 |
| CA2439827A1 (en) | 2002-09-12 |
| WO2002070541A2 (en) | 2002-09-12 |
| PE20020906A1 (es) | 2002-12-08 |
| CZ20032342A3 (cs) | 2004-04-14 |
| KR20030092008A (ko) | 2003-12-03 |
| WO2002070541A3 (en) | 2002-12-19 |
| CN1505607A (zh) | 2004-06-16 |
| IL157643A0 (en) | 2004-03-28 |
| JP2004537507A (ja) | 2004-12-16 |
| BR0207810A (pt) | 2008-04-15 |
| US7019003B2 (en) | 2006-03-28 |
| AU2002335490B2 (en) | 2005-10-20 |
| UY27192A1 (es) | 2002-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |