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AR030189A1 - Compuesto de benzotiazol, uso del mismo para preparar una composicion farmaceutica y dicha composicion farmaceutica - Google Patents

Compuesto de benzotiazol, uso del mismo para preparar una composicion farmaceutica y dicha composicion farmaceutica

Info

Publication number
AR030189A1
AR030189A1 ARP010100543A ARP010100543A AR030189A1 AR 030189 A1 AR030189 A1 AR 030189A1 AR P010100543 A ARP010100543 A AR P010100543A AR P010100543 A ARP010100543 A AR P010100543A AR 030189 A1 AR030189 A1 AR 030189A1
Authority
AR
Argentina
Prior art keywords
heterocyclyl
chx2
heterocyclyloxy
alkyl
alkynyl
Prior art date
Application number
ARP010100543A
Other languages
English (en)
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of AR030189A1 publication Critical patent/AR030189A1/es

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

Un compuesto de benzotiazol caracterizado porque es de la formula (1), mezclas racémicas-diastereoméricas, isomeros opticos, profármacos, isotopos o sales farmacéuticamente aceptables de dicho compuesto, isomeros, profármacos e isotopos, donde Q es H o representa un enlace que está tomado junto con X1 y los dos átomos de nitrogeno a los que Q y X1 están unidos y el grupo C = Y al que están unidos los dos átomos de nitrogeno para formar la formula (2), donde Q es como se describe en la memoria. W es H, Cl, Br, I, NO2, CN, SCN, OCF3, -Xq-(C(R10)2)a-Y1q-(C(R10)2)a-Z1q, o un grupo opcionalmente sustituido seleccionado del grupo que consiste en alquilo, alquenilo, alquinilo, heterociclil-alquenilo y heterociclil-alquinilo; X1 es hidrogeno, alquilo, hidroxialquilo o representa un enlace que está formado junto con R3 tal como se describe a continuacion, o representa un enlace que está tomado con Q tal como se describio anteriormente; R1 y R2 son cada uno, de manera independiente, hidrogeno, halogeno, hidroxi, nitro, ciano, COOH, COOX3, SX3, SO2X3, SOX3, C(O)X3, NHC(O)X3, C(O)NHX3, NHSO2X3 o están seleccionados de un grupo opcionalmente sustituido que consiste en alquilo, alquenilo, alquinilo, alcoxi, amino, NHX3, NX3X3, alquilamino, arilamino, heterociclilamino, alquiltio, alquilsulfonato, arilo, ariloxi, arilalquilo, arilalquenilo, arilalquinilo, arilalquiloxi, heterociclilo, heterocicliloxi, heterociclil-alquilo, heterociclil-alquenilo, heterociclil-alquinilo, heterociclil-alquiloxi, heterocicliltio, heterociclilsulfinilo, heterociclilsulfonilo, cicloalquilo, -(CH2)m, - (CHX2)CN, -(CH2)m- (CHX2)COOH, -(CH2)m-CHX2)COOX3, (CH2)m-(CHX2)SO2X3, -(CH2)m-(CHX2)C(O)X3, -(CH2)m-(CHX2)C(O)NHX3 y -(CH2)m- (CHX2)NHSO2X3; donde m, X2 y X3 son como se describen en la memoria; o cuando R1 está en la posicion 7 del anillo del benzotiazol, R1 y W pueden tomarse juntos con los átomos de carbono a los que están unidos, para formar un anillo heterocíclico opcionalmente sustituido de 5 o 6 miembros; R3 es hidrogeno, o una parte opcionalmente sustituida seleccionada del grupo que consiste en carbonilo, alquilo, alquenilo, alquinilo, cicloalquilo, arilo, arilalquilo, heterociclilo, heterociclil-alquilo, heterociclilheterociclilo, heterociclil-cicloalquilo, amino, alquilamino, arilamino, alcoxi, tioalcoxi y acilo; o R3 y X1 están formados juntos con el átomo de nitrogeno al que están unidos para formar las formulas (3), (4) o (5), donde Z y n son como se describen en la memoria. Uso de dicho compuesto para preparar una composicion farmacéutica util para tratar un estado, trastorno o enfermedad controlables inhibiendo proteinquinasa; donde dicho estado, trastorno o enfermedad están seleccionados del grupo que consiste en trastornos hiperproliferativos, ulcera, enfermedad de Lyme, sepsis, enfermedad de von Hippel Lindau, males penfigoideos, psoriasis, antropatía psoriásica, síndrome paraneoplásico, y otros tal como se describe en la memoria. Composicion farmacéutica que comprende un portador o diluyente farmacéuticamente aceptable y una cantidad efectiva de dicho compuesto.
ARP010100543A 2000-02-07 2001-02-07 Compuesto de benzotiazol, uso del mismo para preparar una composicion farmaceutica y dicha composicion farmaceutica AR030189A1 (es)

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