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AR024240A1 - COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS - Google Patents

COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS

Info

Publication number
AR024240A1
AR024240A1 ARP990106644A ARP990106644A AR024240A1 AR 024240 A1 AR024240 A1 AR 024240A1 AR P990106644 A ARP990106644 A AR P990106644A AR P990106644 A ARP990106644 A AR P990106644A AR 024240 A1 AR024240 A1 AR 024240A1
Authority
AR
Argentina
Prior art keywords
preparation
pharmaceutical composition
prepare
compounds
gastrointestinal disorders
Prior art date
Application number
ARP990106644A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR024240A1 publication Critical patent/AR024240A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuestos de formula (1) su forma estereoquímicamente isomérica, su forma de N-oxido o su sal de adicion de ácido farmacéuticamente aceptable, en donde R1R2, R3, R4, R5, L tienen los significados dados en la memoria descriptiva. Se describen ademásun proceso para su preparacion , composiciones farmacéuticas, enparticular para el tratamiento o prevencion de trastornos gastrointestinales, que comprenden dichos compuestos intermediarios.
ARP990106644A 1998-12-22 1999-12-21 COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS AR024240A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22

Publications (1)

Publication Number Publication Date
AR024240A1 true AR024240A1 (es) 2002-09-25

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990106644A AR024240A1 (es) 1998-12-22 1999-12-21 COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS

Country Status (34)

Country Link
US (2) US6544997B1 (es)
EP (1) EP1140915B1 (es)
JP (1) JP4615725B2 (es)
KR (1) KR100633680B1 (es)
CN (1) CN1150190C (es)
AR (1) AR024240A1 (es)
AT (1) ATE297917T1 (es)
AU (1) AU770397B2 (es)
BG (1) BG64953B1 (es)
BR (1) BR9916491A (es)
CA (1) CA2355857C (es)
CZ (1) CZ300851B6 (es)
DE (1) DE69925865T2 (es)
DK (1) DK1140915T3 (es)
EA (1) EA003608B1 (es)
EE (1) EE200100335A (es)
ES (1) ES2245131T3 (es)
HK (1) HK1039114B (es)
HR (1) HRP20010445A2 (es)
HU (1) HUP0104838A3 (es)
ID (1) ID28953A (es)
IL (1) IL143858A (es)
MY (1) MY121852A (es)
NO (1) NO321324B1 (es)
NZ (1) NZ512871A (es)
PL (1) PL197409B1 (es)
PT (1) PT1140915E (es)
SI (1) SI1140915T1 (es)
SK (1) SK285829B6 (es)
TR (1) TR200101962T2 (es)
TW (1) TW570920B (es)
UA (1) UA71591C2 (es)
WO (1) WO2000037461A1 (es)
ZA (1) ZA200105135B (es)

Families Citing this family (24)

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WO2004024143A1 (ja) * 2002-09-12 2004-03-25 Nagase Chemtex Corporation 医薬組成物
JP4767844B2 (ja) * 2003-06-19 2011-09-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−アンタゴニストとしての複素環式置換４−（アミノメチル）−ピペリジンベンズアミド
PL1641783T3 (pl) 2003-06-19 2012-08-31 Janssen Pharmaceutica Nv 4-(aminometylo)-piperydyno-benzamidy podstawione aminosulfonylem jako antagoniści 5HT₄
JO2478B1 (en) 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
US7498347B2 (en) 2003-06-19 2009-03-03 Janssen Pharmaceutica, N.V. Hydroxycarbonylphenyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4 antagonists
PL1638959T3 (pl) * 2003-06-19 2008-02-29 Janssen Pharmaceutica Nv 4-(Aminometylo)piperydynobenzamidy antagonistyczne względem 5HT4
DK1664036T3 (da) * 2003-09-03 2012-02-13 Pfizer Benzimidazolonforbindelser med 5-HT4-receptoragonistisk virkning
US7964727B2 (en) * 2003-11-24 2011-06-21 Pfizer Inc. Quinolonecarboxylic acid compounds having 5-HT4 receptor agonistic activity
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
KR100875558B1 (ko) 2004-06-15 2008-12-23 화이자 인코포레이티드 벤즈이미다졸론 카복실산 유도체
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
EP1807422B1 (en) * 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
EP1807423B1 (en) * 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
RU2404179C2 (ru) * 2004-12-22 2010-11-20 Тереванс, Инк. Индазол-карбоксамидные соединения
WO2006094063A1 (en) * 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
KR20220066252A (ko) 2019-07-11 2022-05-24 프락시스 프리시젼 메디신즈, 인크. T형 칼슘 채널 조절제의 제형 및 이의 사용 방법

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NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
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Also Published As

Publication number Publication date
CZ300851B6 (cs) 2009-08-26
HK1039114B (zh) 2005-08-19
DK1140915T3 (da) 2005-10-10
SK8592001A3 (en) 2002-02-05
NO20012858D0 (no) 2001-06-08
PT1140915E (pt) 2005-11-30
ZA200105135B (en) 2002-06-21
ES2245131T3 (es) 2005-12-16
HUP0104838A3 (en) 2003-05-28
UA71591C2 (en) 2004-12-15
WO2000037461A1 (en) 2000-06-29
EA003608B1 (ru) 2003-06-26
US7205410B2 (en) 2007-04-17
EA200100710A1 (ru) 2001-12-24
JP4615725B2 (ja) 2011-01-19
AU2432800A (en) 2000-07-12
ID28953A (id) 2001-07-19
EP1140915B1 (en) 2005-06-15
SI1140915T1 (sl) 2005-12-31
IL143858A0 (en) 2002-04-21
TR200101962T2 (tr) 2002-04-22
NZ512871A (en) 2002-11-26
BG105571A (en) 2002-01-31
MY121852A (en) 2006-02-28
HUP0104838A2 (hu) 2002-07-29
BR9916491A (pt) 2001-09-04
CN1331690A (zh) 2002-01-16
CN1150190C (zh) 2004-05-19
CA2355857C (en) 2008-10-28
PL197409B1 (pl) 2008-03-31
NO20012858L (no) 2001-06-08
EE200100335A (et) 2002-08-15
KR20010080293A (ko) 2001-08-22
EP1140915A1 (en) 2001-10-10
US6544997B1 (en) 2003-04-08
CA2355857A1 (en) 2000-06-29
IL143858A (en) 2005-03-20
AU770397B2 (en) 2004-02-19
HK1039114A1 (en) 2002-04-12
NO321324B1 (no) 2006-04-24
HRP20010445A2 (en) 2002-06-30
PL348417A1 (en) 2002-05-20
US20030181456A1 (en) 2003-09-25
JP2002533337A (ja) 2002-10-08
TW570920B (en) 2004-01-11
ATE297917T1 (de) 2005-07-15
DE69925865T2 (de) 2006-05-11
CZ20012117A3 (cs) 2001-10-17
DE69925865D1 (de) 2005-07-21
BG64953B1 (bg) 2006-10-31
SK285829B6 (sk) 2007-09-06
KR100633680B1 (ko) 2006-10-11

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