AR021427A1 - Compuestos de benzimidazol que son antagonistas de receptor de vitronectina - Google Patents
Compuestos de benzimidazol que son antagonistas de receptor de vitronectinaInfo
- Publication number
- AR021427A1 AR021427A1 ARP990106061A ARP990106061A AR021427A1 AR 021427 A1 AR021427 A1 AR 021427A1 AR P990106061 A ARP990106061 A AR P990106061A AR P990106061 A ARP990106061 A AR P990106061A AR 021427 A1 AR021427 A1 AR 021427A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- arylcycloalkyl
- heterocycloalkylalkyl
- heteroaralkyl
- cycloalkylalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona compuestos que tienen la formula (1), en donde n, p, q y r son cada uno independientemente seleccionados entre0 o 1; a, b, c y d representan cada uno independientemente un átomo de carbono o nitrogeno, con la condicion que no más de dos a, b, c y d sean átomosde nitrogeno; Y e Y1 representan cada uno independientemente 1-4 sustituyentes opcionales seleccionados entre alquilo, alcoxi, halo, -CF3 y -C(O)OH; R1 es Halquilo, arilo, aralquilo, arilcicloalquilo, heteroarilo, cicloalquilo, heterocicloalquilo, heteroaralquilo, cicloalquilalquilo, heterocicloalquilalquilo,NHRA, -NHC(O)RA, -NHSO2RA, NHC(O)NHRA, o -NHC(O)ORA; R1 es opcionalmente sustituido con 1-3 grupos seleccionados entre halo, alquilo, -CF3, -CN, -ORB, -SRB,SRB, -CO2RB, -C(O)RB, -OC(O)RB, -OC(O)ORB y -SO2RB, y RA y RB son independientemente seleccionados entre H, alquilo, arilo, aralquilo, arilcicloalquilo,heteroarilo, cicloalquilo, heterocicloalquilo, heteroaralquilo, cicloalquilalquilo o heterocicloalquilalquilo, con la condicion que cuando R1 es alquilo,R1 no es sustituido con halo, la condicion que cuando R1 es -NHSO2RA o -NHC(O)ORA, RA no es H, y la condicion que para -SO2RB o -OC(O)ORB, RB no esH; R2 es H, alquilo, arilo, aralquilo,arilcicloalquilo, heteroarilo, cicloalquilo, heterocicloalquilo, heteroaralquilo, cicloalquilalquilo,o heterocicloalquilalquilo; R2 es opcionalmente sustituido con 1-3 grupos seleccionados entre halo, alquilo, -CF3, -CN, -ORC, -SRC, -CO2RC, -C(O)RC,-OC(O)RC,-OC(O)ORC y -SO2RC, en donde RC se selecciona entre H, alquilo, arilo, aralquilo, arilcicloalquilo, heteroarilo, cicloalquilo, heterocicloalquilo,heteroaralquilo, cicloalquilalquilo o heterocicloalquilalquilo, con la condicion que cuando R2es alquilo, R2 no es sustituido con halo, y la condicion quepara -SO2RC o -OC(O)ORC, RC no es H; R3 es H, alquilo, aralquilo, arilcicloalquilo, cicloalquilalquilo, heterocicloalquilalquilo, heteroaralquilo, arilo,heteroarilo, cicloalquilo, heterocicloalquilo, -C(O)RD, -C(O)ORD, -SO2RE, -C(O)NRFRG, -C(O)NRFSO2RE, o -C(=S)NRFRG, en donde RD, RE, RF y RG son
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20161198A | 1998-11-30 | 1998-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021427A1 true AR021427A1 (es) | 2002-07-17 |
Family
ID=22746536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106061A AR021427A1 (es) | 1998-11-30 | 1999-11-29 | Compuestos de benzimidazol que son antagonistas de receptor de vitronectina |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1135374B9 (es) |
| JP (1) | JP4480117B2 (es) |
| CN (1) | CN1161340C (es) |
| AR (1) | AR021427A1 (es) |
| AT (1) | ATE338751T1 (es) |
| AU (1) | AU1908400A (es) |
| CA (1) | CA2353063C (es) |
| CO (1) | CO5140112A1 (es) |
| DE (1) | DE69933135T2 (es) |
| ES (1) | ES2273517T3 (es) |
| PE (1) | PE20001427A1 (es) |
| WO (1) | WO2000032578A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1148349C (zh) * | 1999-04-07 | 2004-05-05 | 参天制药株式会社 | N-取代-N′-取代脲衍生物及其用作TNF-α生成抑制剂的用途 |
| WO2000069810A1 (en) * | 1999-05-17 | 2000-11-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| FR2809396B1 (fr) * | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| EP2527430B1 (en) | 2007-06-07 | 2014-12-31 | Novozymes A/S | Method of preparing a dough-based product |
| EP2595488B1 (en) | 2010-07-21 | 2019-12-04 | Novozymes A/S | Process for preparing a baked product with anti-staling amylase and peptidase |
| CA2939021C (en) | 2014-02-11 | 2022-07-12 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| EP3105209B1 (en) | 2014-02-11 | 2019-08-21 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| CN104694290A (zh) * | 2014-05-07 | 2015-06-10 | 宁波职业技术学院 | 一种洗脚皂 |
| ES2814151T3 (es) | 2014-10-23 | 2021-03-26 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | 1-Ciclohexilo-2-fenilaminobenzimidazoles como inhibidores de MIDH1 para el tratamiento de tumores |
| JP6783756B2 (ja) | 2014-10-23 | 2020-11-11 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としてのベンゾイミダゾール−２−アミン |
| JP6830909B2 (ja) | 2015-06-08 | 2021-02-17 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としてのＮ−メンチルベンズイミダゾール |
| EP3322694B1 (en) | 2015-07-16 | 2020-02-19 | Bayer Pharma Aktiengesellschaft | 5-hydroxyalkylbenzimidazoles as midh1 inhibitors |
| TW202146416A (zh) | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| CA3174507A1 (en) | 2020-03-06 | 2021-09-10 | Bayer Aktiengesellschaft | Imidazotriazines acting on cancer via inhibition of cdk12 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995032710A1 (en) * | 1994-05-27 | 1995-12-07 | Merck & Co., Inc. | Compounds for inhibiting osteoclast-mediated bone resorption |
| CA2193966A1 (en) * | 1994-06-29 | 1996-01-11 | Fadia El-Fehail Ali | Vitronectin receptor antagonists |
-
1999
- 1999-09-29 CN CNB998158429A patent/CN1161340C/zh not_active Expired - Fee Related
- 1999-11-29 CA CA002353063A patent/CA2353063C/en not_active Expired - Fee Related
- 1999-11-29 AT AT99962691T patent/ATE338751T1/de not_active IP Right Cessation
- 1999-11-29 JP JP2000585220A patent/JP4480117B2/ja not_active Expired - Lifetime
- 1999-11-29 EP EP99962691A patent/EP1135374B9/en not_active Expired - Lifetime
- 1999-11-29 DE DE69933135T patent/DE69933135T2/de not_active Expired - Lifetime
- 1999-11-29 WO PCT/US1999/026023 patent/WO2000032578A1/en active IP Right Grant
- 1999-11-29 AR ARP990106061A patent/AR021427A1/es unknown
- 1999-11-29 ES ES99962691T patent/ES2273517T3/es not_active Expired - Lifetime
- 1999-11-29 AU AU19084/00A patent/AU1908400A/en not_active Abandoned
- 1999-11-30 PE PE1999001198A patent/PE20001427A1/es not_active Application Discontinuation
- 1999-11-30 CO CO99075257A patent/CO5140112A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1908400A (en) | 2000-06-19 |
| CO5140112A1 (es) | 2002-03-22 |
| PE20001427A1 (es) | 2000-12-18 |
| WO2000032578A8 (en) | 2002-02-07 |
| JP2002531441A (ja) | 2002-09-24 |
| CA2353063C (en) | 2009-06-16 |
| ES2273517T3 (es) | 2007-05-01 |
| JP4480117B2 (ja) | 2010-06-16 |
| CN1333755A (zh) | 2002-01-30 |
| DE69933135T2 (de) | 2007-08-09 |
| DE69933135D1 (de) | 2006-10-19 |
| CA2353063A1 (en) | 2000-06-08 |
| EP1135374B9 (en) | 2007-02-21 |
| ATE338751T1 (de) | 2006-09-15 |
| CN1161340C (zh) | 2004-08-11 |
| EP1135374A1 (en) | 2001-09-26 |
| EP1135374B1 (en) | 2006-09-06 |
| WO2000032578A1 (en) | 2000-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |