AR021241A1 - PROTEASE INHIBITORS - Google Patents
PROTEASE INHIBITORSInfo
- Publication number
- AR021241A1 AR021241A1 ARP990105737A ARP990105737A AR021241A1 AR 021241 A1 AR021241 A1 AR 021241A1 AR P990105737 A ARP990105737 A AR P990105737A AR P990105737 A ARP990105737 A AR P990105737A AR 021241 A1 AR021241 A1 AR 021241A1
- Authority
- AR
- Argentina
- Prior art keywords
- protease inhibitors
- inhibitors
- decartilage
- inhibition
- diseases
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Este se refiere a compuestos de la formula (1), en la que: n es 1 o 2; o una de sus sales farmacéuticamente aceptables, que son inhibidores de cisteína-proteasas, particularmente catepsina K, y son utiles en el tratamiento de enfermedades en las quela inhibicion de la pérdida de huesos o de la degradacion decartílagos constituye un factor.This refers to compounds of the formula (1), in which: n is 1 or 2; or one of its pharmaceutically acceptable salts, which are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which the inhibition of bone loss or decartilage degradation constitutes a factor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10841098P | 1998-11-13 | 1998-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021241A1 true AR021241A1 (en) | 2002-07-03 |
Family
ID=22322023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105737A AR021241A1 (en) | 1998-11-13 | 1999-11-11 | PROTEASE INHIBITORS |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR021241A1 (en) |
| AU (1) | AU1393900A (en) |
| CO (1) | CO5150165A1 (en) |
| PE (1) | PE20001237A1 (en) |
| WO (1) | WO2000029408A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| US6534498B1 (en) | 1999-11-10 | 2003-03-18 | Smithkline Beecham Corporation | Protease inhibitors |
| AU1588901A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
| US6583137B1 (en) | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
| OA12323A (en) | 2000-03-21 | 2006-05-15 | Smithkline Beecham Corp | Protease inhibitors. |
| WO2002088106A2 (en) * | 2000-11-17 | 2002-11-07 | Medivir Ab | Cysteine protease inhibitors |
| CA2435117A1 (en) * | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
| US6958358B2 (en) | 2001-01-17 | 2005-10-25 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| CN1269822C (en) | 2001-01-17 | 2006-08-16 | 阿姆拉医疗有限公司 | Inhibitors of Cruz protease and other cysteine proteases |
| US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| JP2005515254A (en) | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | Cycloalkylketoamide derivatives useful as cathepsin K inhibitors |
| WO2009087379A2 (en) | 2008-01-09 | 2009-07-16 | Amura Therapeutics Limited | Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
| CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
| MA26487A1 (en) * | 1997-04-29 | 2004-12-20 | Smithkline Beecham Corp | PROTEASE INHIBITOR HETEROCYCLECETOHYDRAZIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| AR013079A1 (en) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | SUBSTITUTED DERIVATIVES OF TETRAHIDROFURANO-3-ONAS, TETRAHIDROPIRANO-3- ONAS AND TETRAHIDROTIOFEN-3-ONAS, A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION OF A MEDICINAL PRODUCT USEFUL AS INTERMEDIATE PROTEIN INHIBITORS |
| PE73799A1 (en) * | 1997-05-08 | 1999-10-22 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
| CN1255119A (en) * | 1997-05-08 | 2000-05-31 | 史密丝克莱恩比彻姆公司 | Protease inhibitors |
| MA26618A1 (en) * | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MALARIA |
| MA26631A1 (en) * | 1998-05-21 | 2004-12-20 | Smithkline Beecham Corp | NEW BIS-AMINOMETHYL-CARBONYL FUNCTIONAL COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1999
- 1999-11-10 CO CO99070943A patent/CO5150165A1/en unknown
- 1999-11-11 AR ARP990105737A patent/AR021241A1/en unknown
- 1999-11-12 PE PE1999001145A patent/PE20001237A1/en not_active Application Discontinuation
- 1999-11-12 WO PCT/GB1999/003777 patent/WO2000029408A1/en not_active Ceased
- 1999-11-12 AU AU13939/00A patent/AU1393900A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20001237A1 (en) | 2000-12-23 |
| CO5150165A1 (en) | 2002-04-29 |
| AU1393900A (en) | 2000-06-05 |
| WO2000029408A1 (en) | 2000-05-25 |
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