AR018608A1 - PHARMACEUTICAL COMPOSITION OF 3- [4- (2-PHENYL-INDOL-1-ILMETILE) -PENYL] -ACRYLAMIDE AND STROGEN AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents
PHARMACEUTICAL COMPOSITION OF 3- [4- (2-PHENYL-INDOL-1-ILMETILE) -PENYL] -ACRYLAMIDE AND STROGEN AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCTInfo
- Publication number
- AR018608A1 AR018608A1 ARP990102309A AR018608A1 AR 018608 A1 AR018608 A1 AR 018608A1 AR P990102309 A ARP990102309 A AR P990102309A AR 018608 A1 AR018608 A1 AR 018608A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- group
- unsaturated
- independently selected
- Prior art date
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- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composicion farmacéutica que contiene uno o más estrogenos y compuestos de 3-[4-(2-fenil-indol-1-ilmetil)-fenil]-acrilamida que son utiles como agentesestrogénicos, los compuestos tienen la siguiente estructura general,de formulas (I) donde R1 se selecciona de H, OH o ésteres de C1-4 o sus alquil ésteres, ohalogeno;R2,R3,R4,R5 y R6 se seleccionan independientemente de H,OH o ésteres C1-C4 o sus alquil éteres, halogeno, ciano, alquilo C1-6, trifluorometilo, conla condicion de que cuando R1 es H,R2 no es OH; X se selecciona de H, alquilo C1-6, ciano, nitro, trifluormetilo, halogeno; Y se selecciona de a) la porcion(II),donde R7 y R8 se seleccionan independientemente del grupo formado por H, alquilo C1-6, o fenilo, b) un heterociclo de 5 miembros saturado, no saturado oparcialmente no saturado que contiene hasta 2 heteroátomos seleccionados del grupo formado por -O-, -NH-, -N(alquilo C1-4), -N=, y -S(O)m-,donde m es un enteroentre 0-2, opcionalmente sustituido por 1-3 sustituyentes independientemente seleccionados del grupo formado por H, hidroxilo, halo, alquilo de C1-4,trihalometilo, alcoxi C1-4,trihalometoxi,aciloxi C1-4, alquiltio C1-4,alquilsulfinilo C1-4,alquilsulfonilo C1-4,hidroxi alquilo C1-4, -CO2H, -CN-, -CONHR1-,-NH2-,alquilamino C1-4, dialquilamino C1-4,-NHSO2R1-, NHCOR1-,-NO2 y fenilo sustituido con 1-3 alquilo C1-4; a)un heterociclo de 6 miembros saturados,no saturadoso parcialmente no saturados que contiene hasta 2 heteroátomos seleccionados del grupo formado por -O-, NH-, -N(alquilo C1-4)-, -N=, y- S(O)m-, donde m es unentero entre 0-2, opcionalmente sustituido con 1-3 sustituyentes independientemente seleccionados del grupo formado por H, hidroxilo, halo, alquilo C1-4,trihalometilo,alcoxi C1-4,trihalometoxi,aciloxi C1-4,alquiltio C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4,hidroxi alquilo C1-4, -CO2H-, -CN-, -CONHR1-,-NH2-, alquilamino C1-4, dialquilamino C1-4, -NHSO2R1-, -NHCOR1-,-NO2- y fenilo opcionalmente sustituido con 1-3 alquilo (C1-4); d) un heterociclo de 7miembros saturado, no saturado o parcialmente no saturado que contiene hasta 2 heteroátomos seleccionados del grupo formado por -O-, -NH-, -N(alquilo C1-4)-, -Pharmaceutical composition containing one or more estrogens and compounds of 3- [4- (2-phenyl-indole-1-ylmethyl) -phenyl] -acrylamide which are useful as estrogenic agents, the compounds have the following general structure, of formulas (I ) where R1 is selected from H, OH or C1-4 esters or their alkyl esters, ohalogen; R2, R3, R4, R5 and R6 are independently selected from H, OH or C1-C4 esters or their alkyl ethers, halogen, cyano, C1-6 alkyl, trifluoromethyl, with the proviso that when R1 is H, R2 is not OH; X is selected from H, C1-6 alkyl, cyano, nitro, trifluoromethyl, halogen; Y is selected from a) the portion (II), where R7 and R8 are independently selected from the group consisting of H, C1-6 alkyl, or phenyl, b) a saturated, unsaturated or partially unsaturated 5-membered heterocycle containing up to 2 heteroatoms selected from the group consisting of -O-, -NH-, -N (C1-4 alkyl), -N =, and -S (O) m-, where m is an integer between 0-2, optionally substituted by 1 -3 substituents independently selected from the group consisting of H, hydroxyl, halo, C 1-4 alkyl, trihalomethyl, C 1-4 alkoxy, trihalomethoxy, C 1-4 acyloxy, C 1-4 alkylthio, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, hydroxy C1-4 alkyl, -CO2H, -CN-, -CONHR1 -, - NH2-, C1-4 alkylamino, C1-4 dialkylamino, -NHSO2R1-, NHCOR1 -, - NO2 and phenyl substituted with 1-3 C1 alkyl 4; a) a 6-membered saturated, unsaturated, partially unsaturated heterocycle containing up to 2 heteroatoms selected from the group consisting of -O-, NH-, -N (C1-4 alkyl) -, -N =, and- S (O ) m-, where m is a binder between 0-2, optionally substituted with 1-3 substituents independently selected from the group consisting of H, hydroxyl, halo, C1-4 alkyl, trihalomethyl, C1-4 alkoxy, trihalomethoxy, C1-4 acyloxy , C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, hydroxy C1-4 alkyl, -CO2H-, -CN-, -CONHR1 -, - NH2-, C1-4 alkylamino, C1-4 dialkylamino, -NHSO2R1 -, -NHCOR1 -, - NO2- and phenyl optionally substituted with 1-3 (C1-4) alkyl; d) a saturated, unsaturated or partially unsaturated 7-member heterocycle containing up to 2 heteroatoms selected from the group consisting of -O-, -NH-, -N (C1-4 alkyl) -, -
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7964498A | 1998-05-15 | 1998-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018608A1 true AR018608A1 (en) | 2001-11-28 |
Family
ID=45606514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102309 AR018608A1 (en) | 1998-05-15 | 1999-05-14 | PHARMACEUTICAL COMPOSITION OF 3- [4- (2-PHENYL-INDOL-1-ILMETILE) -PENYL] -ACRYLAMIDE AND STROGEN AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR018608A1 (en) |
-
1999
- 1999-05-14 AR ARP990102309 patent/AR018608A1/en unknown
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