AR017867A1 - A HYDRAULATE OF THE MALEIC ACID SALT OF 5-4-2- (N-METHYL-N (2-PIRIDIL) AMINO) ETOXI BENCIL TIAZOLIDIN-2,4-DIONA, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. - Google Patents
A HYDRAULATE OF THE MALEIC ACID SALT OF 5-4-2- (N-METHYL-N (2-PIRIDIL) AMINO) ETOXI BENCIL TIAZOLIDIN-2,4-DIONA, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.Info
- Publication number
- AR017867A1 AR017867A1 ARP980106366A AR017867A1 AR 017867 A1 AR017867 A1 AR 017867A1 AR P980106366 A ARP980106366 A AR P980106366A AR 017867 A1 AR017867 A1 AR 017867A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- methyl
- manufacture
- pharmaceutical composition
- preparation
- Prior art date
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Abstract
Un hidrato de la sal de ácido maleico de 5-[4-[2(N-metil-N-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona, donde: (i) comprende agua en elintervalo de 0,4 a 2,5% p/p; y (ii) proporciona un espectro infrarrojo que contienen picos a 1749, 1703, 1645, 1623, 1365 y 736 cm(-1); y/o (iii) proporcionaun modelo de difraccion de rayos X en polvo (XRPD) sustancialmente como se presenta en la Figura II y/o (iv) proporciona un espectro Raman que contienepicos a 3106, 3069, 3002, 2961, 1750, 1718, 1684,1385, 1335, 1229,,1078, 917, 428 y 349 cm(-1) y/o (v) proporciona un espectro de resonancia magnéticaen estado solido que contiene desplazamientos químicos sustancialmente como los presentados en la Tabla II; y un proceso para la preparacion de talcompuesto, una composicion farmacéutica que contiene tal compuesto y el uso de dicho hidrato para la fabricacion de un medicamento para el tratamientoy/o profilaxis de la diabetes mellitus, condiciones asociadas con la diabetes mellitus y ciertas complicaciones de la misma.A hydrate of the maleic acid salt of 5- [4- [2 (N-methyl-N- (2-pyridyl) amino) ethoxy] benzyl] thiazolidin-2,4-dione, wherein: (i) comprises water in the range of 0.4 to 2.5% w / w; and (ii) provides an infrared spectrum containing peaks at 1749, 1703, 1645, 1623, 1365 and 736 cm (-1); and / or (iii) provides a powder X-ray diffraction (XRPD) model substantially as presented in Figure II and / or (iv) provides a Raman spectrum containing peaks at 3106, 3069, 3002, 2961, 1750, 1718 , 1684,1385, 1335, 1229,, 1078, 917, 428 and 349 cm (-1) and / or (v) provide a solid-state magnetic resonance spectrum that contains chemical shifts substantially as presented in Table II; and a process for the preparation of such a compound, a pharmaceutical composition containing such a compound and the use of said hydrate for the manufacture of a medicament for the treatment and / or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications of the same.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP980106366 AR017867A1 (en) | 1998-12-15 | 1998-12-15 | A HYDRAULATE OF THE MALEIC ACID SALT OF 5-4-2- (N-METHYL-N (2-PIRIDIL) AMINO) ETOXI BENCIL TIAZOLIDIN-2,4-DIONA, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP980106366 AR017867A1 (en) | 1998-12-15 | 1998-12-15 | A HYDRAULATE OF THE MALEIC ACID SALT OF 5-4-2- (N-METHYL-N (2-PIRIDIL) AMINO) ETOXI BENCIL TIAZOLIDIN-2,4-DIONA, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017867A1 true AR017867A1 (en) | 2001-10-24 |
Family
ID=45606385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106366 AR017867A1 (en) | 1998-12-15 | 1998-12-15 | A HYDRAULATE OF THE MALEIC ACID SALT OF 5-4-2- (N-METHYL-N (2-PIRIDIL) AMINO) ETOXI BENCIL TIAZOLIDIN-2,4-DIONA, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR017867A1 (en) |
-
1998
- 1998-12-15 AR ARP980106366 patent/AR017867A1/en unknown
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