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AR015894A1 - USE OF 5- [4- [2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI] BENCIL] TIAZOLIDIN-2,4-DIONA AND INSULIN FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINS SUCH COMPOUNDS - Google Patents

USE OF 5- [4- [2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI] BENCIL] TIAZOLIDIN-2,4-DIONA AND INSULIN FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINS SUCH COMPOUNDS

Info

Publication number
AR015894A1
AR015894A1 ARP980102886A ARP980102886A AR015894A1 AR 015894 A1 AR015894 A1 AR 015894A1 AR P980102886 A ARP980102886 A AR P980102886A AR P980102886 A ARP980102886 A AR P980102886A AR 015894 A1 AR015894 A1 AR 015894A1
Authority
AR
Argentina
Prior art keywords
insulin
amino
methyl
compounds
preparation
Prior art date
Application number
ARP980102886A
Other languages
Spanish (es)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR015894A1 publication Critical patent/AR015894A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Uso de 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona (compuesto I) e insulina para la preparacion de un medicamento util para eltratamiento de diabetes mellitus y procesos asociados a la diabetes mellitus en un mamífero, que comprende una cantidad eficaz, no toxica y farmacéuticamenteeficaz de compuesto I e insulina a un mamífero con necesidad de ello; y una composicion farmacéutica que contiene dichos compuestos.Use of 5- [4- [2- (N-methyl-N- (2-pyridyl) amino) ethoxy] benzyl] thiazolidin-2,4-dione (compound I) and insulin for the preparation of a medicament useful for treatment of diabetes mellitus and processes associated with diabetes mellitus in a mammal, comprising an effective, non-toxic and pharmaceutically effective amount of compound I and insulin to a mammal in need thereof; and a pharmaceutical composition containing said compounds.

ARP980102886A 1997-06-18 1998-06-17 USE OF 5- [4- [2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI] BENCIL] TIAZOLIDIN-2,4-DIONA AND INSULIN FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINS SUCH COMPOUNDS AR015894A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9712866.4A GB9712866D0 (en) 1997-06-18 1997-06-18 Novel method of treatment

Publications (1)

Publication Number Publication Date
AR015894A1 true AR015894A1 (en) 2001-05-30

Family

ID=10814527

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP980102883A AR012997A1 (en) 1997-06-18 1998-06-17 USE OF 5- [4- [2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI] BENCIL] THIAZOLIDIN-2,4- DIONA AND INSULIN FOR THE PREPARATION OF MEDICINES, AND CONTAINING PHARMACEUTICAL COMPOSITION.
ARP980102886A AR015894A1 (en) 1997-06-18 1998-06-17 USE OF 5- [4- [2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI] BENCIL] TIAZOLIDIN-2,4-DIONA AND INSULIN FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINS SUCH COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP980102883A AR012997A1 (en) 1997-06-18 1998-06-17 USE OF 5- [4- [2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI] BENCIL] THIAZOLIDIN-2,4- DIONA AND INSULIN FOR THE PREPARATION OF MEDICINES, AND CONTAINING PHARMACEUTICAL COMPOSITION.

Country Status (30)

Country Link
EP (1) EP0999837A1 (en)
JP (1) JP2002504138A (en)
KR (1) KR20010013843A (en)
CN (1) CN1133431C (en)
AP (1) AP1287A (en)
AR (2) AR012997A1 (en)
AU (1) AU8216398A (en)
BG (1) BG104059A (en)
BR (1) BR9810444A (en)
CA (1) CA2294141A1 (en)
CO (1) CO4940454A1 (en)
DZ (1) DZ2521A1 (en)
EA (1) EA004800B1 (en)
GB (1) GB9712866D0 (en)
HU (1) HUP0003260A3 (en)
ID (1) ID23951A (en)
IL (1) IL133143A0 (en)
IN (1) IN189723B (en)
MA (1) MA26511A1 (en)
NO (1) NO996265D0 (en)
OA (1) OA11517A (en)
PE (1) PE104499A1 (en)
PL (1) PL343123A1 (en)
SK (1) SK179399A3 (en)
TR (1) TR199903095T2 (en)
TW (1) TW587937B (en)
UA (1) UA70299C2 (en)
UY (1) UY25050A1 (en)
WO (1) WO1998057636A1 (en)
ZA (1) ZA985237B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291495B1 (en) * 1997-02-24 2001-09-18 Robert B. Rieveley Method and composition for the treatment of diabetes
TWI249401B (en) 1999-04-14 2006-02-21 Takeda Chemical Industries Ltd Agent for improving ketosis
MXPA01010820A (en) 1999-04-23 2002-06-04 Smithkline Beecham Plc Novel pharmaceutical.
DE60036367T2 (en) * 1999-06-21 2008-05-29 Eli Lilly And Co., Indianapolis SYNERGISTIC USE OF THIAZOLIDINEDIONES AND GLUCAGON-LIKE PEPTIDE-1 AND THEIR AGONISTS FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES
JP2003503356A (en) * 1999-06-25 2003-01-28 メドトロニック ミニメド インコーポレイテッド Multidrug diabetes treatment
US6468507B1 (en) * 2000-05-01 2002-10-22 Aeropharm Technology, Inc. Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
GB0023970D0 (en) * 2000-09-29 2000-11-15 Smithkline Beecham Plc Novel pharmaceutical
US6852694B2 (en) 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
US6531461B1 (en) 2001-06-04 2003-03-11 Louis Obyo Obyo Nelson Medicament for the treatment of diabetes
US20020198203A1 (en) * 2001-06-07 2002-12-26 Wyeth Combination of a PTPase inhibitor and a thiazolidinedione agent
US6737401B2 (en) 2001-06-28 2004-05-18 Metronic Minimed, Inc. Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom
ES2295692T3 (en) * 2002-11-08 2008-04-16 F. Hoffmann-La Roche Ag NEW DERIVATIVES OF 4-ALCOXIOXAZOL REPLACED AS PPAR AGONISTS.
US7264813B2 (en) 2003-09-24 2007-09-04 Nikken Sohonsha Corporation Therapeutic uses of Dunaliella powder
CN102389427A (en) * 2011-10-10 2012-03-28 成都恒瑞制药有限公司 Solid oral preparation containing rosiglitazone and cetirizine hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1714652A3 (en) * 1993-09-15 2007-01-17 Sankyo Company, Limited Use of thiazolidinediones to prevent or delay onset of niddm
KR19990036290A (en) * 1995-08-10 1999-05-25 로즈 암스트롱 Reduction of Exogenous Insulin Dosage in Non-insulin-Dependent Diabetic Patients
ATE259227T1 (en) * 1995-09-18 2004-02-15 Ligand Pharm Inc TREATMENT OF NIDDM (NON-INSULIN DEPENDENT DIABETES MELLITUS) WITH RXR AGONISTS

Also Published As

Publication number Publication date
GB9712866D0 (en) 1997-08-20
PL343123A1 (en) 2001-07-30
ID23951A (en) 2000-06-08
CO4940454A1 (en) 2000-07-24
EA004800B1 (en) 2004-08-26
AP1287A (en) 2004-06-26
IN189723B (en) 2003-04-19
TW587937B (en) 2004-05-21
SK179399A3 (en) 2000-11-07
EA200000042A1 (en) 2000-08-28
AR012997A1 (en) 2000-11-22
DZ2521A1 (en) 2003-02-08
CN1260715A (en) 2000-07-19
HUP0003260A3 (en) 2001-12-28
KR20010013843A (en) 2001-02-26
NO996265L (en) 1999-12-17
CA2294141A1 (en) 1998-12-23
HUP0003260A2 (en) 2001-05-28
EP0999837A1 (en) 2000-05-17
JP2002504138A (en) 2002-02-05
IL133143A0 (en) 2001-03-19
AP9901718A0 (en) 1999-12-31
OA11517A (en) 2004-02-04
TR199903095T2 (en) 2000-08-21
BR9810444A (en) 2000-09-05
BG104059A (en) 2000-10-31
AU8216398A (en) 1999-01-04
MA26511A1 (en) 2004-12-20
PE104499A1 (en) 2000-01-13
UY25050A1 (en) 2000-09-29
NO996265D0 (en) 1999-12-17
ZA985237B (en) 2000-02-17
WO1998057636A1 (en) 1998-12-23
CN1133431C (en) 2004-01-07
UA70299C2 (en) 2004-10-15

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