AR014977A1 - Procedimiento de preparacion de la 3-hidroximetilquinuclidina, un compuesto intermediario de sintesis para dicho procedimiento y procedimiento de preparacion de mequitazina - Google Patents
Procedimiento de preparacion de la 3-hidroximetilquinuclidina, un compuesto intermediario de sintesis para dicho procedimiento y procedimiento de preparacion de mequitazinaInfo
- Publication number
- AR014977A1 AR014977A1 ARP990101658A ARP990101658A AR014977A1 AR 014977 A1 AR014977 A1 AR 014977A1 AR P990101658 A ARP990101658 A AR P990101658A AR P990101658 A ARP990101658 A AR P990101658A AR 014977 A1 AR014977 A1 AR 014977A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- preparation procedure
- preparation
- hydroximethylquinuclidine
- mequitazine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- HOKDBMAJZXIPGC-UHFFFAOYSA-N Mequitazine Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1CC1C(CC2)CCN2C1 HOKDBMAJZXIPGC-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960005042 mequitazine Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- GUAWHSHTXVVCLZ-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-ylmethanol Chemical compound C1CC2C(CO)CN1CC2 GUAWHSHTXVVCLZ-UHFFFAOYSA-N 0.000 abstract 3
- ICSMHHPNBLZOLB-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octane-3-carbonitrile Chemical compound C1CC2C(C#N)CN1CC2 ICSMHHPNBLZOLB-UHFFFAOYSA-N 0.000 abstract 2
- ZKMZPXWMMSBLNO-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-one Chemical compound C1CC2C(=O)CN1CC2 ZKMZPXWMMSBLNO-UHFFFAOYSA-N 0.000 abstract 1
- HMLQKWGSQOBMRL-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octane-3-carbaldehyde Chemical compound C1CC2C(C=O)CN1CC2 HMLQKWGSQOBMRL-UHFFFAOYSA-N 0.000 abstract 1
- IGWSUNSXCGQMBN-UHFFFAOYSA-N 3-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-ol Chemical compound C1CC2C(COC)(O)CN1CC2 IGWSUNSXCGQMBN-UHFFFAOYSA-N 0.000 abstract 1
- GSPNHQCETISFOY-UHFFFAOYSA-N 3-methylidene-1-oxido-1-azoniabicyclo[2.2.2]octane Chemical compound C1CC2CC[N+]1([O-])CC2=C GSPNHQCETISFOY-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento de preparacion de la 3-hidroximetilquinuclidina, de formula 1, donde se transforma el oxido de 3-metilenquinuclidina 4 o la 3-quinuclidinona3 de formulas 3 y 4 en 3-metoximetil-3-quinuclidinol 6 de formula 6 y después en 3-formilquinuclidina 8 de formula 8 y porque se reduce para recuperar la3-hidroximetilquinuclidina 1 o porque se transforma la 3-quinuclidinona 3 en 3-cianoquinuclidina 9 de formula 9, porque se hidroliza la 3-cianoquinuclidina 9 aácido 10 de formula 10 y porque sereduce a 3-hidroximetilquinuclidina 1; y un compuesto intermediario para dicho procedimiento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9804451A FR2777278B1 (fr) | 1998-04-09 | 1998-04-09 | Nouveau procede de preparation de la 3-hydroxymethyl quinuclidine, intermediaire de synthese de la mequitazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014977A1 true AR014977A1 (es) | 2001-04-11 |
Family
ID=9525062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101658A AR014977A1 (es) | 1998-04-09 | 1999-04-09 | Procedimiento de preparacion de la 3-hidroximetilquinuclidina, un compuesto intermediario de sintesis para dicho procedimiento y procedimiento de preparacion de mequitazina |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR014977A1 (es) |
| ES (1) | ES2162550B1 (es) |
| FR (1) | FR2777278B1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2911606B1 (fr) | 2007-01-18 | 2009-04-17 | Pierre Fabre Medicament Sa | Nouveau derive de la quinuclidine utile dans la preparation de la mequitazine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2522660A1 (fr) * | 1982-03-05 | 1983-09-09 | Pharmuka Lab | Isomere levogyre de la mequitazine, son procede de preparation et medicaments le contenant |
| FR2531955A1 (fr) * | 1982-08-17 | 1984-02-24 | Pharmuka Lab | Nouveau procede de preparation de derives de la quinuclidine substitues en position 3 |
| DE3827117A1 (de) * | 1988-08-10 | 1990-02-15 | Ruetgerswerke Ag | Verfahren zur herstellung von chinuclidin-3-methanol |
| US5137895A (en) * | 1991-04-29 | 1992-08-11 | A. H. Robins Company, Incorporated | 3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols |
-
1998
- 1998-04-09 FR FR9804451A patent/FR2777278B1/fr not_active Expired - Fee Related
-
1999
- 1999-04-08 ES ES009900709A patent/ES2162550B1/es not_active Withdrawn - After Issue
- 1999-04-09 AR ARP990101658A patent/AR014977A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2162550A1 (es) | 2001-12-16 |
| FR2777278A1 (fr) | 1999-10-15 |
| FR2777278B1 (fr) | 2000-06-30 |
| ES2162550B1 (es) | 2003-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9302214A (es) | Derivados de taxol y proceso para su preparacion | |
| EA200100772A1 (ru) | Бензогетероциклы и их применение в качестве мек ингибиторов | |
| EP1880215A4 (en) | COMPOSITIONS AND METHODS FOR DETECTING SIROLIMUS | |
| HUT39175A (en) | Process for producing 7-/3-aryl-1-piperazinyl/- and 7-/3-cyclohexyl-1-piperazinyl/-3-quinoline-carboxylic acids and pharmaceutical compositions containing them as active agents | |
| PT96664A (pt) | Processo para a preparacao de derivados neuroprotectores de 3-piperidino-4-hidroxicromano | |
| NO924949D0 (no) | Piperidylsubstituerte indoler | |
| EA200100930A1 (ru) | Способ лечения хозл | |
| AR014977A1 (es) | Procedimiento de preparacion de la 3-hidroximetilquinuclidina, un compuesto intermediario de sintesis para dicho procedimiento y procedimiento de preparacion de mequitazina | |
| ATE417059T1 (de) | Verfahren zur herstellung hochreiner nicht toxischer toxinfragmente | |
| DK1347965T3 (da) | Hidtil ukendte desloratidinsalte, fremgangsmåde til syntese deraf samt farmaceutiske præparater deraf | |
| CO4980899A1 (es) | Proceso para la sintesis de los compuestos intermediarios de cloropurina | |
| DK0556813T3 (da) | Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler | |
| KR900700461A (ko) | 5-원자 질소 함유 이종원자 방향족 화합물의 제조방법 | |
| DK1392672T3 (da) | Chlormethylering af thiopen | |
| BG103986A (en) | Derivatives of pyrrolidinecarboxylic acids as endotheline antagonists | |
| AU562643B2 (en) | N-arylpiperazine derivatives | |
| EA200100864A1 (ru) | Способ получения 1,4,7,10-тетраазациклододекана | |
| BG103737A (en) | Method for the preparation of derivatives of 4h-4-oxo-quinolysine-3-carboxylic acid | |
| ES2153902T3 (es) | Derivado ester de acido guanidinometilciclohexanocarboxilico. | |
| ATE111973T1 (de) | Metallschützende zusammensetzungen, ihr herstellungsverfahren und metallschutzverfahren. | |
| ZA86543B (en) | 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics | |
| DK0725785T3 (da) | Fremgangsmåde til fremstilling af rufloxacin af deraf | |
| EA200000168A1 (ru) | Фармацевтическая композиция, снижающая продуцирование белка мср-1 | |
| FI941850A0 (fi) | Uusi yhdiste, joka on leustroduksiini H, sen valmistus ja terapeuttinen käyttö | |
| NO970477D0 (no) | Inhibisjon av leukotrien biosyntese med ureaderivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |