AR013077A1 - Compuestos derivados de aminoacidos, mezclas de los mismos, composiciones farmaceuticas que los comprende, uso de dichos compuestos y proceso depreparacion de los mismos - Google Patents
Compuestos derivados de aminoacidos, mezclas de los mismos, composiciones farmaceuticas que los comprende, uso de dichos compuestos y proceso depreparacion de los mismosInfo
- Publication number
- AR013077A1 AR013077A1 ARP980101853A ARP980101853A AR013077A1 AR 013077 A1 AR013077 A1 AR 013077A1 AR P980101853 A ARP980101853 A AR P980101853A AR P980101853 A ARP980101853 A AR P980101853A AR 013077 A1 AR013077 A1 AR 013077A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- formula
- alkoxy
- linear
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 -Cl or -Br Chemical class 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos derivados de aminoácidos que tienen la formula general (X), en la cual: Y representa: -CONHOH, o -SH, o un grupo de formula (I), un grupode formula (II) en la cual R4 representa -H, o un grupo alquilo C1-6, o un grupo fenilalquilo en el cual el grupo alquilo están en C1-6; R5 representaun grupo de formula (III), en la cual R6 representa -H, o un grupo alcoxi en C1-6 o un grupo benziloxi; R7 representa -H, o un átomo de halogeno como el Clo el Br, R1 representa: una cadena dealquilo lineal o ramificada en C3-16, o ciclada en C3-6, admitiendo dicha cadena, en caso dado, un heteroátomo comoO, S o N; un grupo fenoxialquilo o fenilalquilo, substituidos o no, o un grupo heteroarilalquilo, estando el grupo alquilo enC2-5; R2 representa: unátomo de hidrogeno, o un grupo alquilo en C1-5 o alquilideno en C2-5 o un hidroxilo, un alcoxi en C1-6 o un benziloxi a condicion de que Y representa-CONHOH cuando R2 representa un hidroxilo, o un grupo hidroximetilo oalcoximetilo en C1-6 o un grupo arilalquilo en el cual la parte alquilo estáen C1-6 un grupo ariloximetilo, un grupo ariltiometilo, un grupo heteroariltiometilo, en los cuales arilo designa un residuo feniloeventualmente sustituido, en especial por -OH, OCH3, un grupo alquilo en C1-3 lineal o ramificado, un halogeno, como el -Cl o el -Br, un grupo aminadocomo -NH2, -NHCOCH3, -NHCOOR10, representando R10 un grupo alquilo en C1-3 lineal o ramificado, o un grupoftalimidoalquilo en el cual la parte alquiloestá en C1-6 o un grupo alcoxicarbonilo (con alcoxi designando metoxi, etoxi), un benziloxicarbonilmetilo, un acetilmetilo a condicion, en estos tres casosde que Y represente -SH, -AA representa un ácido aminado, o un encadenamiento de ácidos aminados, siendo estos ácidos naturales o no y ventajosamente de
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9704971A FR2762315B1 (fr) | 1997-04-22 | 1997-04-22 | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013077A1 true AR013077A1 (es) | 2000-12-13 |
Family
ID=9506187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101853A AR013077A1 (es) | 1997-04-22 | 1998-04-22 | Compuestos derivados de aminoacidos, mezclas de los mismos, composiciones farmaceuticas que los comprende, uso de dichos compuestos y proceso depreparacion de los mismos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6344457B1 (es) |
| EP (1) | EP0977730B1 (es) |
| AR (1) | AR013077A1 (es) |
| AT (1) | ATE234278T1 (es) |
| AU (1) | AU7534698A (es) |
| CA (1) | CA2287565A1 (es) |
| CO (1) | CO4950539A1 (es) |
| DE (1) | DE69812082T2 (es) |
| ES (1) | ES2194319T3 (es) |
| FR (1) | FR2762315B1 (es) |
| TN (1) | TNSN98052A1 (es) |
| WO (1) | WO1998047863A1 (es) |
| ZA (1) | ZA983390B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101663T2 (tr) | 1998-12-10 | 2001-11-21 | F.Hoffmann-La Roche Ag | Pro-kollajen c-proteinaz inhibitörleri |
| JP2002538151A (ja) | 1999-03-02 | 2002-11-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | カテプシンの可逆的インヒビターとして有用な化合物 |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| EP1409016B9 (en) | 2001-06-26 | 2020-10-28 | Amgen Fremont Inc. | Antibodies to opgl |
| US6886964B2 (en) * | 2001-06-26 | 2005-05-03 | Allan Gardiner | Illuminator with filter array and bandwidth controller |
| RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
| AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| AU2003299971A1 (en) * | 2002-12-30 | 2004-07-29 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| AU2004263900A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| EP1737499A4 (en) | 2004-03-09 | 2009-07-22 | Arriva Pharmaceuticals Inc | TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER |
| US7638513B2 (en) * | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| EP2586445A1 (en) | 2005-04-15 | 2013-05-01 | University Of North Carolina At Chapel Hill | Methods of facilitating cell survival using neurotrophin mimetics |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
| JP2012519703A (ja) * | 2009-03-06 | 2012-08-30 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | ニューロトロフィン・ミメティック及びその使用 |
| CA2769030C (en) | 2009-07-30 | 2016-05-10 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| CN108383804A (zh) | 2009-11-12 | 2018-08-10 | 特罗菲克斯制药股份有限公司 | 神经营养蛋白模拟化合物及其盐的晶型 |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| AU2986295A (en) * | 1995-07-19 | 1997-02-18 | British Biotech Pharmaceuticals Limited | N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors |
-
1997
- 1997-04-22 FR FR9704971A patent/FR2762315B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-17 TN TNTNSN98052A patent/TNSN98052A1/fr unknown
- 1998-04-21 AU AU75346/98A patent/AU7534698A/en not_active Abandoned
- 1998-04-21 AT AT98922850T patent/ATE234278T1/de not_active IP Right Cessation
- 1998-04-21 US US09/403,037 patent/US6344457B1/en not_active Expired - Fee Related
- 1998-04-21 ES ES98922850T patent/ES2194319T3/es not_active Expired - Lifetime
- 1998-04-21 WO PCT/FR1998/000801 patent/WO1998047863A1/fr active IP Right Grant
- 1998-04-21 EP EP98922850A patent/EP0977730B1/fr not_active Expired - Lifetime
- 1998-04-21 CA CA002287565A patent/CA2287565A1/fr not_active Abandoned
- 1998-04-21 DE DE69812082T patent/DE69812082T2/de not_active Expired - Fee Related
- 1998-04-21 CO CO98021932A patent/CO4950539A1/es unknown
- 1998-04-22 ZA ZA983390A patent/ZA983390B/xx unknown
- 1998-04-22 AR ARP980101853A patent/AR013077A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0977730B1 (fr) | 2003-03-12 |
| ES2194319T3 (es) | 2003-11-16 |
| US6344457B1 (en) | 2002-02-05 |
| AU7534698A (en) | 1998-11-13 |
| CO4950539A1 (es) | 2000-09-01 |
| FR2762315A1 (fr) | 1998-10-23 |
| ATE234278T1 (de) | 2003-03-15 |
| CA2287565A1 (fr) | 1998-10-29 |
| DE69812082D1 (de) | 2003-04-17 |
| FR2762315B1 (fr) | 1999-05-28 |
| ZA983390B (en) | 1999-02-09 |
| WO1998047863A1 (fr) | 1998-10-29 |
| DE69812082T2 (de) | 2003-11-06 |
| TNSN98052A1 (fr) | 2005-03-15 |
| EP0977730A1 (fr) | 2000-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |