AR012124A1 - Un procedimiento para la preparacion de derivados de tiazolidinadiona, derivados de tiazolidinadiona, su uso y preparados farmaceuticos que contienen a dichos derivados. - Google Patents
Un procedimiento para la preparacion de derivados de tiazolidinadiona, derivados de tiazolidinadiona, su uso y preparados farmaceuticos que contienen a dichos derivados.Info
- Publication number
- AR012124A1 AR012124A1 ARP980101266A ARP980101266A AR012124A1 AR 012124 A1 AR012124 A1 AR 012124A1 AR P980101266 A ARP980101266 A AR P980101266A AR P980101266 A ARP980101266 A AR P980101266A AR 012124 A1 AR012124 A1 AR 012124A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- tiazolidinadiona
- preparation
- pharmaceutical preparations
- preparations containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Un procedimiento para la preparacion de derivados de tiazolidinadiona de la formula (III), en donde A es CH = CH o S; W es O; X es S, O o NR2, en dondeel radical R2 es hidrogeno o C1-C6-alquilo; Y es CH o N; R es naftilo, tienilo, o fenilo, elcua l es opcionalmente mono- o disustituido con C1-C3-alquilo,CF3, C1-C3-alcoxi, F, Cl o bromo; R1 significa hidrogeno o C1-C6-alquilo y n significa 1-3; por transformacion de compuestos de la formula (IV), en dondeA, W, X, Y, R, R1 y n poseenlos s ignificados indicados más arriba, con aluminio activado en un solvente protido, derivados de la formula (III) ypreparados farmacéuticos que contienen estos compuestos. Estos derivados presentan un buen perfil de accion en eltratamient o de la diabetesmellitus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19711616A DE19711616A1 (de) | 1997-03-20 | 1997-03-20 | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012124A1 true AR012124A1 (es) | 2000-09-27 |
Family
ID=7824011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101266A AR012124A1 (es) | 1997-03-20 | 1998-03-20 | Un procedimiento para la preparacion de derivados de tiazolidinadiona, derivados de tiazolidinadiona, su uso y preparados farmaceuticos que contienen a dichos derivados. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6258832B1 (es) |
| EP (1) | EP0970077B1 (es) |
| JP (2) | JP3484200B2 (es) |
| KR (1) | KR100340353B1 (es) |
| CN (1) | CN1105718C (es) |
| AR (1) | AR012124A1 (es) |
| AT (1) | ATE240324T1 (es) |
| AU (1) | AU726048B2 (es) |
| BR (1) | BR9808029A (es) |
| CA (1) | CA2285208C (es) |
| DE (2) | DE19711616A1 (es) |
| DK (1) | DK0970077T3 (es) |
| ES (1) | ES2198053T3 (es) |
| HK (1) | HK1025965A1 (es) |
| HU (1) | HUP0001551A3 (es) |
| IL (1) | IL131772A (es) |
| NO (1) | NO313292B1 (es) |
| NZ (1) | NZ337608A (es) |
| PL (1) | PL192201B1 (es) |
| PT (1) | PT970077E (es) |
| RS (1) | RS49771B (es) |
| RU (1) | RU2181724C2 (es) |
| TR (1) | TR199902197T2 (es) |
| TW (1) | TW487707B (es) |
| WO (1) | WO1998042704A1 (es) |
| ZA (1) | ZA982326B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1078923E (pt) | 1999-08-02 | 2006-07-31 | Hoffmann La Roche | Processo para a preparacao de derivados de benzotiofeno |
| US6531609B2 (en) * | 2000-04-14 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for the preparation of thiazolidinedione derivatives |
| FR2820741A1 (fr) * | 2001-02-14 | 2002-08-16 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| FR2820742B1 (fr) * | 2001-02-14 | 2005-03-11 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| US7323481B2 (en) | 2001-04-06 | 2008-01-29 | Hoffmann-La Roche Inc. | Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth |
| RU2278859C2 (ru) * | 2001-05-15 | 2006-06-27 | Ф.Хоффманн-Ля Рош Аг | Замещенные карбоновыми кислотами оксазоловые производные в качестве ppar-альфа и гамма-активаторов при лечении диабета |
| WO2004005266A1 (en) * | 2002-07-03 | 2004-01-15 | F. Hoffmann-La Roche Ag | Oxazole derivatives and their use as insulin sensitizers |
| NZ537897A (en) * | 2002-08-30 | 2007-08-31 | Hoffmann La Roche | Novel 2-arylthiazole compounds as PPARalpha and PPARgamma agonists |
| EP1539746B1 (en) * | 2002-09-12 | 2006-11-15 | F. Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| PL377320A1 (pl) * | 2002-11-25 | 2006-01-23 | F. Hoffmann-La Roche Ag | Pochodne indolilowe |
| US7259176B2 (en) * | 2003-06-26 | 2007-08-21 | Hoffmann-La Roche Inc. | Process for the preparation of the insulin sensitizer |
| US11906176B2 (en) | 2019-12-10 | 2024-02-20 | Lg Electronics Inc. | Air management apparatus or device |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| US4703052A (en) | 1985-05-21 | 1987-10-27 | Pfizer Inc. | Hypoglycemic thiazolidinediones |
| GB8713861D0 (en) | 1987-06-13 | 1987-07-15 | Beecham Group Plc | Compounds |
| ATE186724T1 (de) | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
| WO1989008651A1 (en) | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
| HU217432B (hu) | 1988-03-08 | 2000-01-28 | Pfizer Inc. | Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények |
| US5330998A (en) | 1988-03-08 | 1994-07-19 | Pfizer Inc. | Thiazolidinedione derivatives as hypoglycemic agents |
| WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| DE69132713D1 (de) * | 1990-04-27 | 2001-10-11 | Sankyo Co | Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren |
| KR930701420A (ko) | 1990-08-23 | 1993-06-11 | 알렌 제이. 스피겔 | 혈당저하제로서의 하이드록시우레아 유도체 |
| WO1993013095A1 (en) * | 1991-12-20 | 1993-07-08 | The Upjohn Company | A reduction method for substituted 5-methylene-thiazolidinediones |
| FR2688220A1 (fr) | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE4317320A1 (de) * | 1993-05-25 | 1994-12-01 | Boehringer Mannheim Gmbh | Neue Thiazolidindione und diese enthaltende Arzneimittel |
| CA2157032C (en) | 1993-12-27 | 1999-09-28 | Hisashi Shinkai | Isoxazolidinedione derivative and use thereof |
-
1997
- 1997-03-20 DE DE19711616A patent/DE19711616A1/de not_active Withdrawn
-
1998
- 1998-03-17 KR KR1019997008445A patent/KR100340353B1/ko not_active IP Right Cessation
- 1998-03-17 CN CN98803388A patent/CN1105718C/zh not_active Expired - Fee Related
- 1998-03-17 EP EP98916974A patent/EP0970077B1/de not_active Expired - Lifetime
- 1998-03-17 NZ NZ337608A patent/NZ337608A/en unknown
- 1998-03-17 RU RU99122023/04A patent/RU2181724C2/ru not_active IP Right Cessation
- 1998-03-17 RS YUP-466/99A patent/RS49771B/sr unknown
- 1998-03-17 PT PT98916974T patent/PT970077E/pt unknown
- 1998-03-17 AT AT98916974T patent/ATE240324T1/de not_active IP Right Cessation
- 1998-03-17 PL PL335903A patent/PL192201B1/pl not_active IP Right Cessation
- 1998-03-17 TR TR1999/02197T patent/TR199902197T2/xx unknown
- 1998-03-17 DE DE59808365T patent/DE59808365D1/de not_active Expired - Fee Related
- 1998-03-17 DK DK98916974T patent/DK0970077T3/da active
- 1998-03-17 JP JP54484098A patent/JP3484200B2/ja not_active Expired - Fee Related
- 1998-03-17 AU AU70361/98A patent/AU726048B2/en not_active Ceased
- 1998-03-17 BR BR9808029-6A patent/BR9808029A/pt not_active Application Discontinuation
- 1998-03-17 US US09/381,247 patent/US6258832B1/en not_active Expired - Fee Related
- 1998-03-17 WO PCT/EP1998/001535 patent/WO1998042704A1/de active IP Right Grant
- 1998-03-17 IL IL13177298A patent/IL131772A/en not_active IP Right Cessation
- 1998-03-17 CA CA002285208A patent/CA2285208C/en not_active Expired - Fee Related
- 1998-03-17 TW TW087103935A patent/TW487707B/zh not_active IP Right Cessation
- 1998-03-17 ES ES98916974T patent/ES2198053T3/es not_active Expired - Lifetime
- 1998-03-17 HU HU0001551A patent/HUP0001551A3/hu unknown
- 1998-03-19 ZA ZA9802326A patent/ZA982326B/xx unknown
- 1998-03-20 AR ARP980101266A patent/AR012124A1/es active IP Right Grant
-
1999
- 1999-09-17 NO NO19994505A patent/NO313292B1/no unknown
-
2000
- 2000-08-18 HK HK00105205A patent/HK1025965A1/xx not_active IP Right Cessation
-
2001
- 2001-02-14 US US09/783,494 patent/US6441185B2/en not_active Expired - Fee Related
-
2003
- 2003-08-21 JP JP2003297751A patent/JP2004067697A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |