AR009627A1 - Derivados de n-(imidazolilbutil)bencenosulfonamida su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de n-(imidazolilbutil)bencenosulfonamida su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR009627A1 AR009627A1 ARP970105455A ARP970105455A AR009627A1 AR 009627 A1 AR009627 A1 AR 009627A1 AR P970105455 A ARP970105455 A AR P970105455A AR P970105455 A ARP970105455 A AR P970105455A AR 009627 A1 AR009627 A1 AR 009627A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- application
- benzenosulfonamide
- imidazolylbutyl
- therapeutics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de formula (I): en donde, entre otros significados R1 y R1 representan hidrogeno, halogeno o (C1-C4)alquilo; R2 representa un grupopiperidin-1-ilo, 1,2,3,6-tetrahidropidin-1-ilo eventualmente substituidos, hexahidro-1H-azepin-1-ilo, heptahidroazocin-1-ilo, octahidro-1H-azonin-1-ilo,(1) donde: (A-B = ONR, m = 1 a 2 y p = 1 a 2); (2) donde: (Q = carbono o nitrogeno, D = (C1-C4)alquilo o -CH2CH3, y r = 1 a 3), R3 representa (C1-C5)alquilo, -COR5 [siendo R5 (C1-C4)alquilo,-(CH-2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH-2)nOH (n igual 1 a 4)], -SO2R6, -CONHR6, -SO2N(R6)2 (siendo R6(C1-C4)alquilo; R4 representa hidrogeno o halogeno y A representa fenilo o heterociclo eventualmente substituidos o ciclo(C5-C8)alquilo. Aplicacion enterapéutica: propiedades antitromboticas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614309A FR2756285B1 (fr) | 1996-11-22 | 1996-11-22 | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009627A1 true AR009627A1 (es) | 2000-04-26 |
Family
ID=9497920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105455A AR009627A1 (es) | 1996-11-22 | 1997-11-21 | Derivados de n-(imidazolilbutil)bencenosulfonamida su preparacion y su aplicacion en terapeutica |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0946517A1 (es) |
| JP (1) | JP2001504128A (es) |
| KR (1) | KR20000069063A (es) |
| CN (1) | CN1238765A (es) |
| AR (1) | AR009627A1 (es) |
| AU (1) | AU5226498A (es) |
| BG (1) | BG103414A (es) |
| BR (1) | BR9713291A (es) |
| CA (1) | CA2270478A1 (es) |
| CO (1) | CO4910158A1 (es) |
| CZ (1) | CZ178299A3 (es) |
| EE (1) | EE9900201A (es) |
| FR (1) | FR2756285B1 (es) |
| HU (1) | HUP9904599A2 (es) |
| IL (1) | IL129546A0 (es) |
| NO (1) | NO992436L (es) |
| SK (1) | SK66799A3 (es) |
| TR (1) | TR199901143T2 (es) |
| WO (1) | WO1998022443A1 (es) |
| ZA (1) | ZA9710515B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2783521B1 (fr) * | 1998-09-18 | 2002-04-26 | Synthelabo | Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique |
| FR2806722B1 (fr) * | 2000-03-23 | 2002-05-17 | Sanofi Synthelabo | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
| CN107207403A (zh) | 2014-09-29 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的组合物和方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689130B1 (fr) * | 1992-03-30 | 1994-05-27 | Synthelabo | Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique. |
| FR2710066B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
| FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
| DE19548797A1 (de) * | 1995-12-27 | 1997-07-03 | Thomae Gmbh Dr K | Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
1996
- 1996-11-22 FR FR9614309A patent/FR2756285B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-19 JP JP52328498A patent/JP2001504128A/ja active Pending
- 1997-11-19 SK SK667-99A patent/SK66799A3/sk unknown
- 1997-11-19 EP EP97947089A patent/EP0946517A1/fr not_active Ceased
- 1997-11-19 CN CN97199986A patent/CN1238765A/zh active Pending
- 1997-11-19 HU HU9904599A patent/HUP9904599A2/hu unknown
- 1997-11-19 BR BR9713291-8A patent/BR9713291A/pt not_active Application Discontinuation
- 1997-11-19 IL IL12954697A patent/IL129546A0/xx unknown
- 1997-11-19 TR TR1999/01143T patent/TR199901143T2/xx unknown
- 1997-11-19 CZ CZ991782A patent/CZ178299A3/cs unknown
- 1997-11-19 KR KR1019997004485A patent/KR20000069063A/ko not_active Application Discontinuation
- 1997-11-19 EE EEP199900201A patent/EE9900201A/xx unknown
- 1997-11-19 WO PCT/FR1997/002079 patent/WO1998022443A1/fr not_active Application Discontinuation
- 1997-11-19 CO CO97067574A patent/CO4910158A1/es unknown
- 1997-11-19 AU AU52264/98A patent/AU5226498A/en not_active Abandoned
- 1997-11-19 CA CA002270478A patent/CA2270478A1/en not_active Abandoned
- 1997-11-21 AR ARP970105455A patent/AR009627A1/es unknown
- 1997-11-21 ZA ZA9710515A patent/ZA9710515B/xx unknown
-
1999
- 1999-05-19 BG BG103414A patent/BG103414A/xx unknown
- 1999-05-20 NO NO992436A patent/NO992436L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9713291A (pt) | 1999-10-26 |
| ZA9710515B (en) | 1998-06-10 |
| JP2001504128A (ja) | 2001-03-27 |
| SK66799A3 (en) | 2000-02-14 |
| FR2756285A1 (fr) | 1998-05-29 |
| FR2756285B1 (fr) | 1998-12-18 |
| AU5226498A (en) | 1998-06-10 |
| WO1998022443A1 (fr) | 1998-05-28 |
| CO4910158A1 (es) | 2000-04-24 |
| TR199901143T2 (xx) | 1999-08-23 |
| KR20000069063A (ko) | 2000-11-25 |
| EE9900201A (et) | 1999-12-15 |
| CZ178299A3 (cs) | 1999-08-11 |
| HUP9904599A2 (hu) | 2000-06-28 |
| NO992436D0 (no) | 1999-05-20 |
| EP0946517A1 (fr) | 1999-10-06 |
| IL129546A0 (en) | 2000-02-29 |
| NO992436L (no) | 1999-07-22 |
| CA2270478A1 (en) | 1998-05-28 |
| CN1238765A (zh) | 1999-12-15 |
| BG103414A (en) | 2000-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI840603A (fi) | (2-oxo-1,2,3,5-tetrahydroimidazo/2,1- b/kinazolinyl)-oxialkylamider. | |
| HUP0302367A2 (hu) | HIV Integráz inhibitorokként hasznos aza- és poliazanaftalenil-karboxamidok, ezeket tartalmazó gyógyszerkészítmények | |
| AU528003B2 (en) | N-substituted nitrogen-containing heterocyclic compounds | |
| HUP0001796A2 (hu) | Dipeptid-benzamidinek mint kininogenáz inhibitorok, és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP9902410A2 (hu) | Amidinszármazékok, előállításuk, trombininhibitorként való alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények | |
| ATE215949T1 (de) | Hydroisochinolinderivate | |
| HUP0301387A2 (hu) | Szintetikus módszerek aplidin és új tumorellenes származékok előállítására | |
| NO915068D0 (no) | Fremgangsmaate for fremstilling av nye amino- og nitro-holdige tricykliske forbindelser | |
| DK0684241T3 (da) | N-pyridylcarboxamidderivater, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende disse | |
| MY132009A (en) | Pharmaceutical compounds. | |
| HUP9903590A2 (hu) | 3-(Azetidinil-alkil)-piperidin- vagy -pirrolidin-származékok mint tachikinin-antagonisták | |
| AR009627A1 (es) | Derivados de n-(imidazolilbutil)bencenosulfonamida su preparacion y su aplicacion en terapeutica | |
| MY103905A (en) | Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same. | |
| DK300890A (da) | Kondenserede pyrazol-3-oxo-propannitrilderivater og fremgangsmaade til fremstilling deraf | |
| HUP9901434A2 (hu) | Helyettesített benzil-aminok és alkalmazásuk depresszió kezelésére | |
| IL76175A (en) | N-substituted tricyclic oxindole carboxamides and pharmaceutical compositions containing them | |
| EP0215297A3 (en) | Substituted dipeptide amides | |
| HUP0104944A2 (hu) | Acetamidot és szubsztituált acetamidot tartalmazó tiokarbamidok, mint herpeszvírus inhibitorok és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0303204A2 (hu) | 1-Metilkarbapenem-származékok és ezeket tartalmazó gyógyszerkészítmények | |
| ATE283261T1 (de) | Cyklische amide und imide und deren verwendung als alpha-1d adrenergische rezeptor-antagonisten | |
| ATE273284T1 (de) | Arylphtalazine antagonisten vonexitatonischen amino saüre rezeptoren | |
| MY103515A (en) | Ergolinyl heterocycles | |
| UA41348C2 (uk) | Проліки 3-ацил-2-оксіндол-1-карбоксамідів та фармацевтична композиція | |
| HUP0402229A2 (hu) | TNF-aktivitású tetrahidropiridil-alkil-heterociklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények | |
| TH43749A (th) | อนุพันธ์เบนโซซาซีน การเตรียมและการใช้มันเพื่อการบำบัดรักษาโรค |