AR008494A1 - USE OF PIRAZOLINONES FOR THE TREATMENT OF POWER DISORDERS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, USE OF PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT AND / OR THERAPY OF POWER DISORDERS AND A PROCEDURE FOR PREPARING - Google Patents
USE OF PIRAZOLINONES FOR THE TREATMENT OF POWER DISORDERS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, USE OF PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT AND / OR THERAPY OF POWER DISORDERS AND A PROCEDURE FOR PREPARINGInfo
- Publication number
- AR008494A1 AR008494A1 ARP970104715A ARP970104715A AR008494A1 AR 008494 A1 AR008494 A1 AR 008494A1 AR P970104715 A ARP970104715 A AR P970104715A AR P970104715 A ARP970104715 A AR P970104715A AR 008494 A1 AR008494 A1 AR 008494A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- atoms
- therapy
- disorders
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
El invento se refiere al empleo de las pirazolinonas de formula (I) en donde R1 representa bencilo no sustituido o monosustituido con alcoxi, ofenilo o piridilo no sustituido o mono, di o trisustituido con Hal, NO2, CN, COOH, CONH2, CONHA, CONAA, NH2, NH-CO-A, NH-SO2A, NA-SO2A, NH-CO-OA, SO3H,SO2NH-CO-A, SO2NR4R5, CO-NHSO3H, CO-NHSO2A, tetrazolilo o PO3H. R2 representa A, alcoxi-CO-alquileno, HO-CO-alquileno o HO-alquileno, R3 representa H, A,alcoxi, NH2, NHA, NAA, NH-CO-A o SO2NR4R5;R4, R5 representan independientemente H o A. R4 y R5, juntos, también representan una cadenade alquileno saturada, totalmente o parcialmente insaturada de 4 a 5 miembros, en la que 1 a 3 átomos de C pueden estar reemplazados por N y/o 1 a 2 átomosde C pueden estar reemplazados por 1 a 2 átomos de O y/o 1 a 2 átomos de S. A, A representan independientemente alquilo de 1 a 6 átomos de C, en donde1 a 7 átomos de H pueden estar reemplazados por átomos de F y/o Cl. Hal representa F, Cl, Br o I, para el tratamiento y/o la terapia de los trastornosde la potencia. También se refiere a las preparaciones farmacéuticas que contienen dichos compuestos, al empleo de las mismas para el tratamiento y/o laterapia de lostrastornos de la potencia y a un procedimiento para prepararlas. Los compuestos de formula (I) y sus sales aceptables desde el punto de vistafisiologico pueden ser empleados para combatir enfermedades en las cuales un aumento del nivel de GMPc(monofosfato de guanosina cíclico) detiene oevita la inflamacion y relaja los musculos. En particular, estos compuestos pueden ser empleados para el tratamiento de enfermedades del sistemacardiocirculatorio y para el tratamiento y la terapia delos trastornos de potencia.The invention relates to the use of the pyrazolinones of formula (I) in which R1 represents unsubstituted or monosubstituted benzyl or monosubstituted with alkoxy, ofenyl or pyridyl or mono, di or trisubstituted with Hal, NO2, CN, COOH, CONH2, CONHA, CONAA, NH2, NH-CO-A, NH-SO2A, NA-SO2A, NH-CO-OA, SO3H, SO2NH-CO-A, SO2NR4R5, CO-NHSO3H, CO-NHSO2A, tetrazolyl or PO3H. R2 represents A, alkoxy-CO-alkylene, HO-CO-alkylene or HO-alkylene, R3 represents H, A, alkoxy, NH2, NHA, NAA, NH-CO-A or SO2NR4R5; R4, R5 independently represent H or A Together R4 and R5 also represent a 4- to 5-membered fully or partially unsaturated saturated alkylene chain, in which 1 to 3 C atoms can be replaced by N and / or 1 to 2 C atoms can be replaced by 1 to 2 O atoms and / or 1 to 2 S atoms. A, A independently represent alkyl of 1 to 6 C atoms, wherein 1 to 7 H atoms may be replaced by F and / or Cl atoms. Hal represents F, Cl, Br or I, for the treatment and / or therapy of potency disorders. It also relates to pharmaceutical preparations containing such compounds, their use for the treatment and / or therapy of potency disorders, and a method of preparing them. The compounds of formula (I) and their physiologically acceptable salts can be used to combat diseases in which an increase in the level of cGMP (cyclic guanosine monophosphate) stops or prevents inflammation and relaxes the muscles. In particular, these compounds can be used for the treatment of diseases of the cardiovascular system and for the treatment and therapy of disorders of potency.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642284A DE19642284A1 (en) | 1996-10-14 | 1996-10-14 | Pyrazolinones for the treatment of erectile dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008494A1 true AR008494A1 (en) | 2000-01-19 |
Family
ID=7808669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104715A AR008494A1 (en) | 1996-10-14 | 1997-10-14 | USE OF PIRAZOLINONES FOR THE TREATMENT OF POWER DISORDERS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, USE OF PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT AND / OR THERAPY OF POWER DISORDERS AND A PROCEDURE FOR PREPARING |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0930881A1 (en) |
| JP (1) | JP2001501958A (en) |
| KR (1) | KR20000049086A (en) |
| CN (1) | CN1233178A (en) |
| AR (1) | AR008494A1 (en) |
| AU (1) | AU4945297A (en) |
| BR (1) | BR9712307A (en) |
| CA (1) | CA2268823A1 (en) |
| DE (1) | DE19642284A1 (en) |
| HU (1) | HUP0000233A3 (en) |
| NO (1) | NO991734L (en) |
| PL (1) | PL332821A1 (en) |
| WO (1) | WO1998016224A1 (en) |
| ZA (1) | ZA979151B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
| US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
| US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
| US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
| US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
| US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
| US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
| US6875575B1 (en) | 1998-11-25 | 2005-04-05 | Osi Pharmaceuticals, Inc. | Diagnostic methods for neoplasia |
| US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| DE19518082A1 (en) * | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4 (-Arylaminomethylene) -2,4-dihydropyrazol-3-one |
-
1996
- 1996-10-14 DE DE19642284A patent/DE19642284A1/en not_active Withdrawn
-
1997
- 1997-10-08 PL PL97332821A patent/PL332821A1/en unknown
- 1997-10-08 BR BR9712307-2A patent/BR9712307A/en not_active Application Discontinuation
- 1997-10-08 CN CN97198764A patent/CN1233178A/en active Pending
- 1997-10-08 EP EP97912141A patent/EP0930881A1/en not_active Withdrawn
- 1997-10-08 KR KR1019990703161A patent/KR20000049086A/en not_active Application Discontinuation
- 1997-10-08 HU HU0000233A patent/HUP0000233A3/en unknown
- 1997-10-08 WO PCT/EP1997/005532 patent/WO1998016224A1/en not_active Application Discontinuation
- 1997-10-08 CA CA002268823A patent/CA2268823A1/en not_active Abandoned
- 1997-10-08 JP JP10517987A patent/JP2001501958A/en active Pending
- 1997-10-08 AU AU49452/97A patent/AU4945297A/en not_active Abandoned
- 1997-10-13 ZA ZA9709151A patent/ZA979151B/en unknown
- 1997-10-14 AR ARP970104715A patent/AR008494A1/en unknown
-
1999
- 1999-04-13 NO NO991734A patent/NO991734L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO991734D0 (en) | 1999-04-13 |
| ZA979151B (en) | 1998-05-11 |
| NO991734L (en) | 1999-04-13 |
| CN1233178A (en) | 1999-10-27 |
| PL332821A1 (en) | 1999-10-11 |
| DE19642284A1 (en) | 1998-04-16 |
| AU4945297A (en) | 1998-05-11 |
| HUP0000233A3 (en) | 2001-06-28 |
| KR20000049086A (en) | 2000-07-25 |
| BR9712307A (en) | 1999-08-31 |
| HUP0000233A2 (en) | 2001-04-28 |
| JP2001501958A (en) | 2001-02-13 |
| CA2268823A1 (en) | 1998-04-23 |
| EP0930881A1 (en) | 1999-07-28 |
| WO1998016224A1 (en) | 1998-04-23 |
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