AR008291A1 - Derivados de tetrahidroisoquinolina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su uso para la preparacionde un medicamento. - Google Patents
Derivados de tetrahidroisoquinolina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su uso para la preparacionde un medicamento.Info
- Publication number
- AR008291A1 AR008291A1 ARP970103668A ARP970103668A AR008291A1 AR 008291 A1 AR008291 A1 AR 008291A1 AR P970103668 A ARP970103668 A AR P970103668A AR P970103668 A ARP970103668 A AR P970103668A AR 008291 A1 AR008291 A1 AR 008291A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- group
- optionally substituted
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 150000003976 azacycloalkanes Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- NTNKZGHUNBWBBV-UHFFFAOYSA-N 3,4,4a,5-tetrahydro-2h-isoquinolin-1-one Chemical class C1C=CC=C2C(=O)NCCC21 NTNKZGHUNBWBBV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005422 alkyl sulfonamido group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000005533 aryl carboxamido group Chemical group 0.000 abstract 1
- 125000005421 aryl sulfonamido group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 abstract 1
- WZEOZJQLTRFNCU-UHFFFAOYSA-N trifluoro(trifluoromethoxy)methane Chemical class FC(F)(F)OC(F)(F)F WZEOZJQLTRFNCU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- -1 ulfonyloxy Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de tetrahidroisoquinolona de fórmula (I), en la que: R1 es un sustituyente seleccionado entre: un átomo de hidrógeno o halógeno, un grupohidroxi, ciano, nitro, trifluorometilo, trifluorometoxi,trifluorometanos ulfoniloxi, alquilo C1-4, alcoxi C1-4, aril-alcoxi C1-4,alquiltio C1-4, alcoxi C1-4-alquilo C1-4, cicloalquil C3-6-alcoxi C1-4, alcanoilo C1-4, alcoxi C1-4-carbonilo, alquil C1-4-sulfonilo, alquil C1-4-sulfoniloxi, alquilC1-4-sulfonil-alquil o C1-4, arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo C1-4, alquil C1-4-sulfonamido,alquil C1-4-amido, alquil C1-4-sulfonamido-alquil C1-4, alquil C1-4-amido- alquilo C1-4, arilsulfonamido,arilcarboxamido, arilsulfonamido -alquilo C1-4,aril-carboxamido-alquilo C1-4, aroilo, aroil-alquilo C1-4 o aril-alcanoilo C1-4; un grupo R3OCO(CH2)p, R3CON(R4)(CH2)p, R3R4NCO (CH2)p o R3R4NSO2(CH2)pen los que cada uno de los R3 y R4 sonindependientemente un átomo de hidrógeno o un grupo alquilo C1-4 o R3R4 forma parte de un anillo de azacicloalcanoC3-6 o (2-oxo)-azacicloalcano C3-6 y p es cero o un número entero de 1 a 4; o un grupo Ar1Z, en el que Ar1 es un anillo de feniloopcionalmente sustituidoo un anillo hetero cíclico aromático de 5 o miembros, opcionalmente sustituido, y Z es un enlace, O, s, o CH2; R2 es un átomo de hidrógeno o un grupo alquiloC1-4; q es 1 o 2; Ar es un anillo de fenilo opcionalmentesustituido o un anillo heterocíclico aromático de 5 o 6 miembros, opcionalmente sustituido, oun sistema de anillos aromático o heteroaromático, bicíclico; y sus sales. Un procedimiento para preparar los derivados de tetrahidroisoquinolinadefórmula (I), las composiciones farmacéuticas que los c ontienen y su uso o una sal fisiológicamente aceptable del mismo en la fabricación de un medicamento
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617079.0A GB9617079D0 (en) | 1996-08-14 | 1996-08-14 | Compounds |
| GBGB9704523.1A GB9704523D0 (en) | 1997-03-05 | 1997-03-05 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008291A1 true AR008291A1 (es) | 1999-12-29 |
Family
ID=26309872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103668A AR008291A1 (es) | 1996-08-14 | 1997-08-12 | Derivados de tetrahidroisoquinolina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su uso para la preparacionde un medicamento. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6143762A (es) |
| EP (1) | EP0922035B1 (es) |
| JP (1) | JP2000517301A (es) |
| AR (1) | AR008291A1 (es) |
| AU (1) | AU4204697A (es) |
| CA (1) | CA2263284A1 (es) |
| DE (1) | DE69704060T2 (es) |
| ES (1) | ES2154470T3 (es) |
| WO (1) | WO1998006699A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708694D0 (en) * | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| EP0983244A1 (en) * | 1997-05-03 | 2000-03-08 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
| GB9709303D0 (en) * | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| US5912342A (en) * | 1997-08-12 | 1999-06-15 | Heinonen; Petri | Compounds a containing a solid support |
| US6541487B1 (en) * | 1998-05-01 | 2003-04-01 | R.T. Alamo Ventures I, Llc | PDE III inhibitors for treating sexual dysfunction |
| GB9810876D0 (en) * | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| GB9821978D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| GB9821977D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| CN1329609A (zh) * | 1998-10-08 | 2002-01-02 | 史密丝克莱恩比彻姆有限公司 | 用作多巴胺d3受体调制剂(精神抑制药)的四氢苯并氮杂䓬衍生物 |
| TWI274750B (en) | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
| EP1283199A4 (en) | 2000-05-16 | 2003-12-17 | Takeda Chemical Industries Ltd | MELANINE CONCENTRATING HORMONE ANTAGONISTS |
| WO2003037862A1 (fr) * | 2001-10-30 | 2003-05-08 | Nippon Shinyaku Co., Ltd. | Derives amide, et medicaments correspondants |
| TWI281914B (en) | 2002-05-29 | 2007-06-01 | Glaxo Group Ltd | Compounds |
| JPWO2006054793A1 (ja) * | 2004-11-19 | 2008-06-05 | 財団法人新産業創造研究機構 | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
| WO2010040274A1 (zh) | 2008-10-10 | 2010-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| US10870660B2 (en) | 2016-07-28 | 2020-12-22 | Shionogi & Co., Ltd. | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect |
| JP6545747B2 (ja) * | 2017-05-09 | 2019-07-17 | 山田化学工業株式会社 | 色素化合物 |
| JPWO2019146739A1 (ja) | 2018-01-26 | 2021-01-07 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する縮環化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| US5294621A (en) * | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
| GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| WO1996030333A1 (en) * | 1995-03-27 | 1996-10-03 | Smithkline Beecham Plc | Bicyclic amine derivatives and their use as anti-psychotic agents |
| ES2191838T3 (es) * | 1996-05-11 | 2003-09-16 | Smithkline Beecham Plc | Derivados de tetrahidroisoquinoleina como moduladores de los receptores d3 de la dopamina. |
-
1997
- 1997-08-08 ES ES97940074T patent/ES2154470T3/es not_active Expired - Lifetime
- 1997-08-08 US US09/242,200 patent/US6143762A/en not_active Expired - Fee Related
- 1997-08-08 AU AU42046/97A patent/AU4204697A/en not_active Abandoned
- 1997-08-08 DE DE69704060T patent/DE69704060T2/de not_active Expired - Fee Related
- 1997-08-08 EP EP97940074A patent/EP0922035B1/en not_active Expired - Lifetime
- 1997-08-08 CA CA002263284A patent/CA2263284A1/en not_active Abandoned
- 1997-08-08 JP JP10509410A patent/JP2000517301A/ja not_active Ceased
- 1997-08-08 WO PCT/EP1997/004408 patent/WO1998006699A1/en active IP Right Grant
- 1997-08-12 AR ARP970103668A patent/AR008291A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6143762A (en) | 2000-11-07 |
| EP0922035A1 (en) | 1999-06-16 |
| CA2263284A1 (en) | 1998-02-19 |
| JP2000517301A (ja) | 2000-12-26 |
| DE69704060T2 (de) | 2001-08-02 |
| WO1998006699A1 (en) | 1998-02-19 |
| ES2154470T3 (es) | 2001-04-01 |
| DE69704060D1 (de) | 2001-03-15 |
| AU4204697A (en) | 1998-03-06 |
| EP0922035B1 (en) | 2001-02-07 |
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