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AR005672A1 - Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales. - Google Patents

Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales.

Info

Publication number
AR005672A1
AR005672A1 ARP970100402A ARP970100402A AR005672A1 AR 005672 A1 AR005672 A1 AR 005672A1 AR P970100402 A ARP970100402 A AR P970100402A AR P970100402 A ARP970100402 A AR P970100402A AR 005672 A1 AR005672 A1 AR 005672A1
Authority
AR
Argentina
Prior art keywords
derivatives
antiviral agents
distamicine
tumor
prepare
Prior art date
Application number
ARP970100402A
Other languages
English (en)
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602163.9A external-priority patent/GB9602163D0/en
Priority claimed from GBGB9613987.8A external-priority patent/GB9613987D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of AR005672A1 publication Critical patent/AR005672A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Derivados de la distamicina de fórmula (I), donde: n es 2, 3 o 4; R0 es C1-C4 alquilo o CH2CH2-X2, donde X2 es un átomo halógeno; R1 y R2 sonseleccionados, cada uno por separado, de: hidrógeno, C1-C4 alquilo es opcionalmente sustituidopor uno o más átomos de fluor, C1-C4 alcoxi, yhalógenos, X1 es un halógeno; B es seleccionado de fórmulas (II), donde R3--- R9 son, cada uno en forma independiente, hidrógeno o C1-C1alquilo, y m es 0, 1,o 2, con la condición que, cuando R0 es -CH2CH2- X2, B es diferente de -(CH2)m -NR6R7, y por lo menos uno de R3, R4, R5 es C1-C5 alquilo o una de de la mismafarmacéuticamente aceptable. Dichos compuestos son útiles como agentes antincoplásicos y antivirales.
ARP970100402A 1996-02-02 1997-01-31 Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales. AR005672A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9602163.9A GB9602163D0 (en) 1996-02-02 1996-02-02 Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GBGB9613987.8A GB9613987D0 (en) 1996-07-03 1996-07-03 Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (1)

Publication Number Publication Date
AR005672A1 true AR005672A1 (es) 1999-07-14

Family

ID=26308589

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100402A AR005672A1 (es) 1996-02-02 1997-01-31 Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales.

Country Status (7)

Country Link
US (1) US6165980A (es)
EP (1) EP0880499A1 (es)
JP (1) JP2000503999A (es)
AR (1) AR005672A1 (es)
AU (1) AU1596097A (es)
CA (1) CA2244139C (es)
WO (1) WO1997028123A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806692D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
AU2002312370A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
US6562656B1 (en) * 2001-06-25 2003-05-13 Thin Film Module, Inc. Cavity down flip chip BGA
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
GB0130868D0 (en) 2001-12-24 2002-02-06 Univ Strathclyde New compounds
GB2389581A (en) * 2002-06-12 2003-12-17 Viaxxel Biotech Gmbh Hydrogenated pyrimidines and their use as inhibitors of deoxyhypusine-synthase or hypusination of eIF-5A
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
AU2003297822A1 (en) 2002-12-10 2004-06-30 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
WO2018047148A1 (en) 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) * 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8517922D0 (en) * 1985-07-16 1985-08-21 Erba Farmitalia Carboxamido derivatives
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
AU1596097A (en) 1997-08-22
WO1997028123A1 (en) 1997-08-07
EP0880499A1 (en) 1998-12-02
CA2244139C (en) 2005-06-07
US6165980A (en) 2000-12-26
CA2244139A1 (en) 1997-08-07
JP2000503999A (ja) 2000-04-04

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