[go: up one dir, main page]

AR004682A1 - SUBSTITUTED PHOSPHINIC ACID COMPOUNDS, METHODS FOR PREPARING THEM, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND APPLICATION AS MEDICINES. - Google Patents

SUBSTITUTED PHOSPHINIC ACID COMPOUNDS, METHODS FOR PREPARING THEM, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND APPLICATION AS MEDICINES.

Info

Publication number
AR004682A1
AR004682A1 ARP960104238A AR10423896A AR004682A1 AR 004682 A1 AR004682 A1 AR 004682A1 AR P960104238 A ARP960104238 A AR P960104238A AR 10423896 A AR10423896 A AR 10423896A AR 004682 A1 AR004682 A1 AR 004682A1
Authority
AR
Argentina
Prior art keywords
methods
preparing
substituted
pharmaceutical composition
application
Prior art date
Application number
ARP960104238A
Other languages
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9518186.3A external-priority patent/GB9518186D0/en
Priority claimed from GBGB9613047.1A external-priority patent/GB9613047D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR004682A1 publication Critical patent/AR004682A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3217—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto que es un ácido fosfínico sustituido de la fórmula (I), o una sal o éster del mismo, en la cual fórmula R1 es un grupo monovalente aromáticoo aralifático conectado por intermedio de uno de sus átomos de carbono al átomo de carbono indicado, R2 es un grupo hidrocarbilo no -sustituido o sustituido,RX es hidrógeno o un grupo hidrocarbilo no sustituido o sustituido, RY es hidrógeno; RYa o un grupo NH-protector; y RYa es un grupo hidrocarbilo nosustituido o sustituido, métodos para prepararlos, métodos para preparar intermediarios, composición farmacéutica y su aplicación como medicamento.A compound which is a substituted phosphinic acid of formula (I), or a salt or ester thereof, in which formula R1 is a monovalent aromatic or araliphatic group connected via one of its carbon atoms to the indicated carbon atom, R2 is a non-substituted or substituted hydrocarbyl group, RX is hydrogen or an unsubstituted or substituted hydrocarbyl group, RY is hydrogen; RYa or an NH-protecting group; and RYa is a non-substituted or substituted hydrocarbyl group, methods for preparing them, methods for preparing intermediates, pharmaceutical composition and their application as a medicine.

ARP960104238A 1995-09-07 1996-09-05 SUBSTITUTED PHOSPHINIC ACID COMPOUNDS, METHODS FOR PREPARING THEM, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND APPLICATION AS MEDICINES. AR004682A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9518186.3A GB9518186D0 (en) 1995-09-07 1995-09-07 Chemical Compounds
GBGB9613047.1A GB9613047D0 (en) 1996-06-21 1996-06-21 Chemical compounds

Publications (1)

Publication Number Publication Date
AR004682A1 true AR004682A1 (en) 1999-03-10

Family

ID=26307695

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104238A AR004682A1 (en) 1995-09-07 1996-09-05 SUBSTITUTED PHOSPHINIC ACID COMPOUNDS, METHODS FOR PREPARING THEM, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND APPLICATION AS MEDICINES.

Country Status (15)

Country Link
EP (1) EP0853626A1 (en)
JP (1) JPH11512111A (en)
KR (1) KR19990044452A (en)
CN (1) CN1196057A (en)
AR (1) AR004682A1 (en)
AU (1) AU6831996A (en)
CA (1) CA2229036A1 (en)
CZ (1) CZ66498A3 (en)
HU (1) HUP9802260A3 (en)
IL (1) IL123191A0 (en)
NO (1) NO980994L (en)
PL (1) PL324987A1 (en)
SK (1) SK30198A3 (en)
TR (1) TR199800414T1 (en)
WO (1) WO1997009335A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5859598A (en) * 1996-12-24 1998-07-17 Novartis Ag (thio)morpholine-substituted carboxylic and phosphinic acids
PL3345895T3 (en) 2003-04-11 2020-05-18 Ptc Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease
BRPI0710213A2 (en) 2006-03-30 2011-04-12 Ptc Therapeutics Inc methods for producing an effective amount of a functional transleeding protein encoded by a nucleic acid sequence comprising a nonsense mutation and for treating, controlling and / or preventing disease
WO2015134711A1 (en) 2014-03-06 2015-09-11 Ptc Therapeutics, Inc. Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
CA3003132A1 (en) 2015-10-30 2017-05-04 Ptc Therapeutics, Inc. Methods for treating epilepsy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787617A (en) * 1971-08-16 1973-02-16 Bristol Myers Co IMIDAZOLINES AND PROCESS FOR PREPARING THEM
US4551526A (en) * 1984-09-26 1985-11-05 American Hospital Supply Corporation Synthesis of alpha-aminonitriles
CA2158952C (en) * 1993-03-26 1999-05-18 Shen-Chun Kuo 2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists

Also Published As

Publication number Publication date
PL324987A1 (en) 1998-07-06
JPH11512111A (en) 1999-10-19
NO980994L (en) 1998-04-30
IL123191A0 (en) 1998-09-24
KR19990044452A (en) 1999-06-25
TR199800414T1 (en) 1998-05-21
CA2229036A1 (en) 1997-03-13
MX9801839A (en) 1998-08-30
HUP9802260A2 (en) 1999-05-28
NO980994D0 (en) 1998-03-06
SK30198A3 (en) 1998-08-05
AU6831996A (en) 1997-03-27
EP0853626A1 (en) 1998-07-22
HUP9802260A3 (en) 1999-10-28
CN1196057A (en) 1998-10-14
CZ66498A3 (en) 1998-07-15
WO1997009335A1 (en) 1997-03-13

Similar Documents

Publication Publication Date Title
PT88944A (en) METHOD FOR PREPARING NEW BENZOCYCLETHENE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SE8305299D0 (en) TIAAZA ASSOCIATIONS WITH LACTAMES
AR002240A1 (en) DERIVATIVE OF 2,4-OXAZOLIDINADIONA, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT AND PREPARATION METHOD OF THE SAME.
ES2067456T3 (en) NEW AMINO ACID DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM.
KR890011592A (en) Composition for the treatment of endotracheal ischemia
ATE16488T1 (en) M-4 AND ISOM-4 DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS INCLUDING THEM.
AT384424B (en) METHOD FOR PRODUCING NEW 3-HYDROXY-2-OXO-PYRROLIDINE DERIVATIVES AND THEIR SALTS
ES2096933T3 (en) COMPOUND CAPABLE OF REMAINING IN THE INTRACEREBRAL REGION AND USE THEREOF.
BR9507231A (en) Use of carboxylic acid derivatives for drug production
AR040763A1 (en) PROFARMACOS OF THE (N-2- PIRIDIL-N-2- HYDROXICARBONIL-ETIL) - AMID OF THE ACID 1- METHYL-2- (4-AMIDINOPHENYLAMINOMETIL) - BENZIMIDAZOL-5-IL-CARBOXILICO, ITS PREPARATION AND ITS USE AS MEDICATIONS
AR004682A1 (en) SUBSTITUTED PHOSPHINIC ACID COMPOUNDS, METHODS FOR PREPARING THEM, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND APPLICATION AS MEDICINES.
DE3575715D1 (en) ADAMANTANAMINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINES CONTAINING THEM.
ES2125870T3 (en) SERTINDOL DRUGS.
AR021900A1 (en) DERIVED FROM THE CHROMAN, ITS SALTS AND ENANTIOMERS, A PROCEDURE FOR ITS PREPARATION AND THE USE OF THE SAME AS INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF MEDICINES.
FR2395272A1 (en) NEW MEDICINES DERIVED FROM AMIDINOPENICILLANIC ACID
PT1257552E (en) XANTIN DERIVATIVES, INTERMEDIARIES AND APPLICATION TO THE TREATMENT OF OSTEOPOROSIS
AR008371A1 (en) AN ADDITION SALT WITH ACID OF A 10-AMINOALIFATIL-DIBENZ [B, F], OXEPINE, YOUR EMPLOYMENT; PROCEDURE FOR ITS PREPARATION, A 10-AMINOALIFATIL-DIBENZ [B, F] OXEPINE, A PHARMACEUTICAL PREPARATION CONTAINING SUCH SALT OR SUCH OXEPINE AND A PROCEDURE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
ES2056947T3 (en) OPTICALLY ACTIVE PRODUCTS OF 20,21-DINOREBURNAMENINE DERIVATIVES, THEIR PREPARATION PROCEDURE, THEIR APPLICATION AS DRUGS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
PT82547B (en) PREPARATION PROCEDURE OF HEXENOIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR890012990A (en) Trisubstituted amines Preparations thereof and pharmaceutical compositions containing them
ATE34739T1 (en) NEW 2-PYRIDINE THIOL DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
SE8503225L (en) DIACYLOXI-1,8-ACYL-10 ANTRONS, SET FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT FOR ANIMAL AND HUMAN AND COSMETIC MEDICINES
ES2157498T3 (en) DERIVATIVES OF TRIAZOL OR ITS SALTS.
PT93904A (en) A process for the preparation of novel benzoozole derivatives and pharmaceutical compositions containing them
AR019664A1 (en) COMPOSITION FOR THE TREATMENT OF CARTILAGO DISEASES