AR003456A1 - AN ANALOGUE COMPOUND OF DISTAMICINE AND ITS SALTS, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USES OF THE SAME. - Google Patents
AN ANALOGUE COMPOUND OF DISTAMICINE AND ITS SALTS, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USES OF THE SAME.Info
- Publication number
- AR003456A1 AR003456A1 ARP960103583A AR10358396A AR003456A1 AR 003456 A1 AR003456 A1 AR 003456A1 AR P960103583 A ARP960103583 A AR P960103583A AR 10358396 A AR10358396 A AR 10358396A AR 003456 A1 AR003456 A1 AR 003456A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pharmaceutical composition
- salts
- distamicine
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se presentan nuevos compuestos antitumorales y antivirales análogos a distamicina A de fórmula (I), donde n es 2, 3 ó 4; uno de R y R1 es hidrógeno,alquilo C1-C4, CF3 o alcoxi C1-C4 y la otra es independientemente CF3, alquilo C1-C4 o alcoxi C1-C4; y X es halógeno;y sus sales farmacéuticamente aceptables.Además, la presente invención se refiere a un proceso de preparación de dichos compuestos; a una composición farmacéutica y un producto que lo contiene y ausos de dichos compuestos.New antitumor and antiviral compounds analogous to distamycin A of formula (I) are presented, where n is 2, 3 or 4; one of R and R1 is hydrogen, C1-C4 alkyl, CF3 or C1-C4 alkoxy and the other is independently CF3, C1-C4 alkyl or C1-C4 alkoxy; and X is halogen, and its pharmaceutically acceptable salts. Furthermore, the present invention relates to a process for the preparation of said compounds; to a pharmaceutical composition and a product that contains it and uses of said compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514993.6A GB9514993D0 (en) | 1995-07-21 | 1995-07-21 | Site specific phenyl nitrogen mustards |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003456A1 true AR003456A1 (en) | 1998-08-05 |
Family
ID=10778062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103583A AR003456A1 (en) | 1995-07-21 | 1996-07-15 | AN ANALOGUE COMPOUND OF DISTAMICINE AND ITS SALTS, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USES OF THE SAME. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0787126A1 (en) |
| JP (1) | JPH10506410A (en) |
| KR (1) | KR970706251A (en) |
| CN (1) | CN1159183A (en) |
| AR (1) | AR003456A1 (en) |
| AU (1) | AU6357996A (en) |
| BR (1) | BR9606528A (en) |
| CA (1) | CA2199635A1 (en) |
| EA (1) | EA000033B1 (en) |
| GB (1) | GB9514993D0 (en) |
| HU (1) | HUP9702393A3 (en) |
| IL (1) | IL120342A0 (en) |
| MX (1) | MX9701949A (en) |
| NO (1) | NO971142L (en) |
| PL (1) | PL319352A1 (en) |
| TW (1) | TW367325B (en) |
| WO (1) | WO1997003957A1 (en) |
| ZA (1) | ZA965028B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998037066A1 (en) | 1996-02-26 | 1998-08-27 | California Institute Of Technology | Improved polyamides for binding in the minor groove of double stranded dna |
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| GB9623522D0 (en) * | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
| GB9816652D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| AU2002312370A1 (en) | 2001-06-13 | 2002-12-23 | Roland W. Burli | Antipathogenic benzamide compounds |
| WO2004012736A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| US7265129B2 (en) | 2002-10-25 | 2007-09-04 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| AU2003297822A1 (en) | 2002-12-10 | 2004-06-30 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
| EP2792355A1 (en) | 2013-04-17 | 2014-10-22 | Albert-Ludwigs-Universität Freiburg | Compounds for use as bromodomain inhibitors |
| CN115414356A (en) * | 2022-09-27 | 2022-12-02 | 广西科技大学 | Application of indenopyrrole derivatives in preparation of antitumor pharmaceutical composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
-
1995
- 1995-07-21 GB GBGB9514993.6A patent/GB9514993D0/en active Pending
-
1996
- 1996-06-13 ZA ZA965028A patent/ZA965028B/en unknown
- 1996-06-18 TW TW085107334A patent/TW367325B/en active
- 1996-06-19 JP JP9506209A patent/JPH10506410A/en active Pending
- 1996-06-19 EA EA199700046A patent/EA000033B1/en not_active IP Right Cessation
- 1996-06-19 PL PL96319352A patent/PL319352A1/en unknown
- 1996-06-19 IL IL12034296A patent/IL120342A0/en unknown
- 1996-06-19 EP EP96922849A patent/EP0787126A1/en not_active Withdrawn
- 1996-06-19 HU HU9702393A patent/HUP9702393A3/en unknown
- 1996-06-19 CA CA002199635A patent/CA2199635A1/en not_active Abandoned
- 1996-06-19 MX MX9701949A patent/MX9701949A/en unknown
- 1996-06-19 CN CN96190784A patent/CN1159183A/en active Pending
- 1996-06-19 BR BR9606528A patent/BR9606528A/en not_active Application Discontinuation
- 1996-06-19 AU AU63579/96A patent/AU6357996A/en not_active Abandoned
- 1996-06-19 WO PCT/EP1996/002659 patent/WO1997003957A1/en not_active Application Discontinuation
- 1996-07-15 AR ARP960103583A patent/AR003456A1/en unknown
- 1996-09-19 KR KR1019970701796A patent/KR970706251A/en not_active Application Discontinuation
-
1997
- 1997-03-12 NO NO971142A patent/NO971142L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA199700046A1 (en) | 1997-12-30 |
| ZA965028B (en) | 1997-01-23 |
| EP0787126A1 (en) | 1997-08-06 |
| MX9701949A (en) | 1997-06-28 |
| IL120342A0 (en) | 1997-06-10 |
| BR9606528A (en) | 1997-12-23 |
| NO971142D0 (en) | 1997-03-12 |
| HUP9702393A2 (en) | 1998-04-28 |
| HUP9702393A3 (en) | 1998-05-28 |
| KR970706251A (en) | 1997-11-03 |
| NO971142L (en) | 1997-03-12 |
| AU6357996A (en) | 1997-02-18 |
| TW367325B (en) | 1999-08-21 |
| WO1997003957A1 (en) | 1997-02-06 |
| CA2199635A1 (en) | 1997-02-06 |
| JPH10506410A (en) | 1998-06-23 |
| CN1159183A (en) | 1997-09-10 |
| GB9514993D0 (en) | 1995-09-20 |
| EA000033B1 (en) | 1998-02-26 |
| PL319352A1 (en) | 1997-08-04 |
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