AR003436A1 - Ligandos de p-seletina y moleculas, acidos nucleicos purificados, vector, celula y uso de dichas moleculas para preparar medicamentos. - Google Patents
Ligandos de p-seletina y moleculas, acidos nucleicos purificados, vector, celula y uso de dichas moleculas para preparar medicamentos.Info
- Publication number
- AR003436A1 AR003436A1 ARP960103147A AR10314796A AR003436A1 AR 003436 A1 AR003436 A1 AR 003436A1 AR P960103147 A ARP960103147 A AR P960103147A AR 10314796 A AR10314796 A AR 10314796A AR 003436 A1 AR003436 A1 AR 003436A1
- Authority
- AR
- Argentina
- Prior art keywords
- molecules
- ligands
- nucleic acids
- purified nucleic
- seletine
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 102000008212 P-Selectin Human genes 0.000 abstract 2
- 108010035766 P-Selectin Proteins 0.000 abstract 2
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 206010015866 Extravasation Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000036251 extravasation Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 230000008816 organ damage Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/473—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se describen aquí las moléculas orgánicas a las que están unidos covalentamente un determinante de sialil-Le(x) y un determinante sulfatado, almenos uno de estos determinantes está ubicado en un sitio de ocurrencia no natural en la molécula.También están descriptos los ligandos particulares de laP-selectina y las fusiones del anticuerpo con el ligando de la P.selectina. Estas moléculas, ligandos, y proteínas de fusión son útiles en la reducción yprotección contra la inflamación y las reacciones adversas dependientes de la extravasación, tal como el dano orgánico o coagulación (por ejemplo, asociadocon el síndrome de deficiencia respiratoria del adulto o dano isquémico del miocardio). Asimismo, se describen ácidos nucléicos purificados, vectores,células y el uso de dichas moléculas para preparar medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21395P | 1995-06-14 | 1995-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003436A1 true AR003436A1 (es) | 1998-08-05 |
Family
ID=21690430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103147A AR003436A1 (es) | 1995-06-14 | 1996-06-13 | Ligandos de p-seletina y moleculas, acidos nucleicos purificados, vector, celula y uso de dichas moleculas para preparar medicamentos. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0833650A4 (es) |
| JP (1) | JPH11508131A (es) |
| KR (1) | KR19990022954A (es) |
| AR (1) | AR003436A1 (es) |
| AU (1) | AU6272996A (es) |
| BR (1) | BR9608918A (es) |
| CA (1) | CA2224625A1 (es) |
| CZ (1) | CZ401497A3 (es) |
| HU (1) | HUP9901131A2 (es) |
| IL (1) | IL122590A0 (es) |
| NO (1) | NO975862L (es) |
| TR (1) | TR199701620T1 (es) |
| WO (1) | WO1997000079A1 (es) |
| ZA (1) | ZA965032B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999043834A2 (en) * | 1998-02-27 | 1999-09-02 | Genetics Institute, Inc. | P-selectin ligand protein, including tetrameric fusion proteins |
| CN100347194C (zh) * | 2000-12-29 | 2007-11-07 | 萨文特医药公司 | 分离的包括含硫酸根部分的表位的分子,抗这样的表位的抗体,和它们的应用 |
| JP4599027B2 (ja) * | 2002-10-30 | 2010-12-15 | 東洋水産株式会社 | Ｌ−セレクチン結合阻害剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2086323C (en) * | 1990-07-17 | 2002-05-14 | Rodger P. Mcever | Functionally active selectin-derived peptides and ligand for gmp-140 |
| US5318890A (en) * | 1991-05-06 | 1994-06-07 | The Regents Of The University Of California | Assays for inhibitors of leukocyte adhesion |
| WO1994011498A1 (en) * | 1992-11-16 | 1994-05-26 | Board Of Regents Of The University Of Oklahoma | Glycoprotein ligand for p-selectin and methods of use thereof |
| AU2361395A (en) * | 1994-04-28 | 1995-11-29 | Genetics Institute Inc. | Novel P-selectin ligand protein |
-
1996
- 1996-06-11 IL IL12259096A patent/IL122590A0/xx unknown
- 1996-06-11 EP EP96921519A patent/EP0833650A4/en not_active Withdrawn
- 1996-06-11 CZ CZ974014A patent/CZ401497A3/cs unknown
- 1996-06-11 JP JP9503258A patent/JPH11508131A/ja active Pending
- 1996-06-11 BR BR9608918A patent/BR9608918A/pt not_active Application Discontinuation
- 1996-06-11 HU HU9901131A patent/HUP9901131A2/hu unknown
- 1996-06-11 AU AU62729/96A patent/AU6272996A/en not_active Abandoned
- 1996-06-11 TR TR97/01620T patent/TR199701620T1/xx unknown
- 1996-06-11 CA CA002224625A patent/CA2224625A1/en not_active Abandoned
- 1996-06-11 WO PCT/US1996/010043 patent/WO1997000079A1/en not_active Application Discontinuation
- 1996-06-11 KR KR1019970709424A patent/KR19990022954A/ko not_active Application Discontinuation
- 1996-06-13 ZA ZA965032A patent/ZA965032B/xx unknown
- 1996-06-13 AR ARP960103147A patent/AR003436A1/es unknown
-
1997
- 1997-12-12 NO NO975862A patent/NO975862L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA965032B (en) | 1997-03-14 |
| CA2224625A1 (en) | 1997-01-03 |
| WO1997000079A1 (en) | 1997-01-03 |
| EP0833650A4 (en) | 2005-01-19 |
| IL122590A0 (en) | 1998-06-15 |
| TR199701620T1 (xx) | 1998-05-21 |
| AU6272996A (en) | 1997-01-15 |
| KR19990022954A (ko) | 1999-03-25 |
| JPH11508131A (ja) | 1999-07-21 |
| NO975862L (no) | 1998-02-12 |
| EP0833650A1 (en) | 1998-04-08 |
| BR9608918A (pt) | 1999-06-15 |
| HUP9901131A2 (hu) | 1999-07-28 |
| NO975862D0 (no) | 1997-12-12 |
| CZ401497A3 (cs) | 1998-07-15 |
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