AR003425A1 - Poxvirus recombinante de mapache, vacuna para uso en gatos y uso de poxvirus para preparar una vacuna util para evitar o para disminuir la enfermedad causada por el virus de inmunodeficiencia felina (fiv) - Google Patents
Poxvirus recombinante de mapache, vacuna para uso en gatos y uso de poxvirus para preparar una vacuna util para evitar o para disminuir la enfermedad causada por el virus de inmunodeficiencia felina (fiv)Info
- Publication number
- AR003425A1 AR003425A1 ARP960102963A AR10296396A AR003425A1 AR 003425 A1 AR003425 A1 AR 003425A1 AR P960102963 A ARP960102963 A AR P960102963A AR 10296396 A AR10296396 A AR 10296396A AR 003425 A1 AR003425 A1 AR 003425A1
- Authority
- AR
- Argentina
- Prior art keywords
- poxvirus
- vaccine
- fiv
- prepare
- immunodeficiency virus
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/819—Viral vaccine for feline species, e.g. cats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención proporciona poxvirus recombinantes de mapache (RRPVs) utilizables en vacunas para la profilaxis de enfermedades causadas por el virusde inmunodeficiencia felina (FIV). El RRPV de acuerdo con la invención tiene al menos un genin terno que comprende una secuencia de ADN que codifica unaproteína FIVgag (gag), una proteína FIV encapsulada (env), un polipéptido consistente en aminoácidos 1-735 de FIVenv, o fragmentos inmunogénicos decualquiera de los anteriores. Lasvacuna s que comprenden uno o más de los poxvirus recombinantes de mapache que expresan FIV anteriores pueden tambiéncomprender un portador o diluyente farmacéuticamente aceptable y un adyuvante farmacéuticamente aceptable. La invencióntambién prov ee un uso del poxvirusrecombinante de mapache para preparar una vacuna útil para enfermedades causadas por FIV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/482,090 US5820869A (en) | 1995-06-07 | 1995-06-07 | Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection |
Publications (1)
Publication Number | Publication Date |
---|---|
AR003425A1 true AR003425A1 (es) | 1998-08-05 |
Family
ID=23914612
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960102963A AR003425A1 (es) | 1995-06-07 | 1996-06-05 | Poxvirus recombinante de mapache, vacuna para uso en gatos y uso de poxvirus para preparar una vacuna util para evitar o para disminuir la enfermedad causada por el virus de inmunodeficiencia felina (fiv) |
ARP010101441A AR042378A2 (es) | 1995-06-07 | 2001-03-27 | Poxvirus recombinante de mapache, vacuna para uso en gatos y uso de dicho poxvirus para preparar una vacuna eficaz contra la infeccion del virus de inmunodeficiencia felina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010101441A AR042378A2 (es) | 1995-06-07 | 2001-03-27 | Poxvirus recombinante de mapache, vacuna para uso en gatos y uso de dicho poxvirus para preparar una vacuna eficaz contra la infeccion del virus de inmunodeficiencia felina |
Country Status (17)
Country | Link |
---|---|
US (2) | US5820869A (es) |
EP (2) | EP1374910B1 (es) |
JP (1) | JP4052667B2 (es) |
AR (2) | AR003425A1 (es) |
AT (2) | ATE361762T1 (es) |
AU (1) | AU699794B2 (es) |
BR (1) | BR9609089A (es) |
CA (1) | CA2224257C (es) |
CO (1) | CO4750842A1 (es) |
DE (2) | DE69631246T2 (es) |
DK (1) | DK0831921T3 (es) |
ES (1) | ES2213178T3 (es) |
HK (2) | HK1008982A1 (es) |
PT (1) | PT831921E (es) |
SI (1) | SI0831921T1 (es) |
WO (1) | WO1996040268A1 (es) |
ZA (1) | ZA964694B (es) |
Families Citing this family (43)
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US7087234B1 (en) | 1991-07-09 | 2006-08-08 | Cornell Research Foundation, Inc. | Recombinant multivalent viral vaccine |
US6254872B1 (en) * | 1995-08-25 | 2001-07-03 | University Of Florida | Multi-subtype FIV vaccines |
FR2772047B1 (fr) * | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
US6106841A (en) * | 1998-02-04 | 2000-08-22 | Heska Corporation | Delivery method for recombinant raccoon poxvirus |
FR2775601B1 (fr) * | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
FR2776928B1 (fr) * | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
SK16162000A3 (sk) * | 1998-05-01 | 2001-12-03 | Schering-Plough Ltd. | Rekombinantný vírus exprimujúci cudziu dna kódujúcu mačací cd80, mačací ctla-4 alebo mačací cd86 a jeho použitie |
US7279168B2 (en) | 1998-05-01 | 2007-10-09 | Texas A & M University System | Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof |
US6458528B1 (en) * | 1998-05-15 | 2002-10-01 | Idexx Laboratories, Inc. | Diagnosis of feline immunodeficiency virus infection using ENV/GAG polypeptide markers |
EP1087789A2 (en) * | 1998-06-26 | 2001-04-04 | Aventis Pasteur | Use of poxviruses as enhancer of specific immunity |
US6294176B1 (en) * | 1998-07-10 | 2001-09-25 | Schering-Plough Veterinary Corp. | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species |
AU2799400A (en) * | 1999-01-29 | 2000-08-18 | Bavarian Nordic Research Institute A/S | Multiplex real-time pcr |
US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
EP1074625A3 (en) | 1999-06-14 | 2002-01-02 | Pfizer Products Inc. | DNA vaccine against feline immunodeficiency virus |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
MY129765A (en) | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
US20030129161A1 (en) * | 2001-09-17 | 2003-07-10 | Hsien-Jue Chu | Interleukin-12 as a veterinary vaccine adjuvant |
EP2107374A1 (en) * | 2003-09-11 | 2009-10-07 | Idexx Laboratories, Inc. | Polypeptide for diagnosis of vaccination |
EP1709447B1 (en) * | 2003-12-18 | 2009-06-24 | Idexx Laboratories, Inc. | Method for detecting feline immunodeficiency virus |
CA2556141A1 (en) * | 2004-02-19 | 2005-09-01 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
WO2005123756A1 (en) * | 2004-06-21 | 2005-12-29 | University Of Guelph | A method of diagnosing fiv |
CA2576902C (en) * | 2004-06-30 | 2012-05-08 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
CA2570610A1 (en) * | 2004-06-30 | 2006-02-02 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
AU2005267608B2 (en) * | 2004-06-30 | 2009-01-15 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus (FIV) comprising the use of peptides derived from the V3 region of the FIV env protein |
US7291338B2 (en) * | 2005-03-09 | 2007-11-06 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
JP2010528603A (ja) * | 2007-05-30 | 2010-08-26 | ワイス・エルエルシー | ネコ抗原のアライグマポックスウイルス発現遺伝子 |
EP2553452B1 (en) | 2010-04-02 | 2015-03-04 | IDEXX Laboratories, Inc. | Detection of feline immunodeficiency virus |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
CA2925281C (en) | 2013-09-25 | 2022-05-03 | Zoetis Services Llc | Pcv2b divergent vaccine composition and methods of use |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
JP7060324B2 (ja) | 2013-12-20 | 2022-04-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | ネオ抗原ワクチンによる併用療法 |
EP3757211A1 (en) | 2014-12-19 | 2020-12-30 | The Broad Institute, Inc. | Methods for profiling the t-cell-receptor repertoire |
WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
IL255769B2 (en) | 2015-05-20 | 2023-09-01 | Broad Inst Inc | shared neoantigens |
TWI750122B (zh) | 2015-06-09 | 2021-12-21 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
US20190346442A1 (en) | 2016-04-18 | 2019-11-14 | The Broad Institute, Inc. | Improved hla epitope prediction |
WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
US20210382068A1 (en) | 2018-10-02 | 2021-12-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
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GB9215233D0 (en) * | 1992-07-17 | 1992-09-02 | Pitman Moore Inc | Vaccines |
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JPH08501452A (ja) * | 1992-09-21 | 1996-02-20 | ビアジーン,インコーポレイティド | Felv及び/又はfivに対する組換レトロウィルスベクター |
GB9219936D0 (en) * | 1992-09-21 | 1992-11-04 | Pitman Moore Inc | Vaccines |
WO1994020622A1 (en) * | 1993-03-11 | 1994-09-15 | Akzo Nobel N.V. | Polypeptide fragment capable of inducing neutralising antibodies against feline immuno-deficiency virus |
TW377373B (en) * | 1993-09-22 | 1999-12-21 | Wyeth Corp | Recombinant raccoon pox viruses and their use as an effective vaccine against feline infectious peritonitis virus disease |
-
1995
- 1995-06-07 US US08/482,090 patent/US5820869A/en not_active Expired - Lifetime
-
1996
- 1996-06-03 EP EP03013934A patent/EP1374910B1/en not_active Expired - Lifetime
- 1996-06-03 WO PCT/US1996/008508 patent/WO1996040268A1/en active IP Right Grant
- 1996-06-03 AT AT03013934T patent/ATE361762T1/de not_active IP Right Cessation
- 1996-06-03 SI SI9630663T patent/SI0831921T1/xx unknown
- 1996-06-03 AT AT96917038T patent/ATE257015T1/de not_active IP Right Cessation
- 1996-06-03 DE DE69631246T patent/DE69631246T2/de not_active Expired - Fee Related
- 1996-06-03 BR BR9609089A patent/BR9609089A/pt not_active Application Discontinuation
- 1996-06-03 AU AU59731/96A patent/AU699794B2/en not_active Ceased
- 1996-06-03 DE DE69637080T patent/DE69637080T2/de not_active Expired - Fee Related
- 1996-06-03 DK DK96917038T patent/DK0831921T3/da active
- 1996-06-03 PT PT96917038T patent/PT831921E/pt unknown
- 1996-06-03 ES ES96917038T patent/ES2213178T3/es not_active Expired - Lifetime
- 1996-06-03 CA CA002224257A patent/CA2224257C/en not_active Expired - Fee Related
- 1996-06-03 JP JP50108697A patent/JP4052667B2/ja not_active Expired - Fee Related
- 1996-06-03 EP EP96917038A patent/EP0831921B1/en not_active Expired - Lifetime
- 1996-06-05 ZA ZA9604694A patent/ZA964694B/xx unknown
- 1996-06-05 AR ARP960102963A patent/AR003425A1/es unknown
- 1996-06-06 CO CO96029449A patent/CO4750842A1/es unknown
-
1998
- 1998-01-15 US US09/007,383 patent/US5989562A/en not_active Expired - Lifetime
- 1998-08-07 HK HK98109771A patent/HK1008982A1/xx not_active IP Right Cessation
-
2001
- 2001-03-27 AR ARP010101441A patent/AR042378A2/es active IP Right Grant
-
2004
- 2004-05-28 HK HK04103836A patent/HK1060847A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU699794B2 (en) | 1998-12-17 |
DE69631246T2 (de) | 2004-11-25 |
BR9609089A (pt) | 1999-02-02 |
HK1008982A1 (en) | 1999-05-21 |
PT831921E (pt) | 2004-05-31 |
US5989562A (en) | 1999-11-23 |
ATE257015T1 (de) | 2004-01-15 |
DE69637080D1 (de) | 2007-06-21 |
WO1996040268A1 (en) | 1996-12-19 |
ATE361762T1 (de) | 2007-06-15 |
SI0831921T1 (en) | 2004-06-30 |
DE69637080T2 (de) | 2008-01-10 |
ZA964694B (en) | 1997-12-05 |
EP1374910B1 (en) | 2007-05-09 |
CO4750842A1 (es) | 1999-03-31 |
AU5973196A (en) | 1996-12-30 |
EP0831921A1 (en) | 1998-04-01 |
ES2213178T3 (es) | 2004-08-16 |
CA2224257A1 (en) | 1996-12-19 |
AR042378A2 (es) | 2005-06-22 |
JP4052667B2 (ja) | 2008-02-27 |
DE69631246D1 (de) | 2004-02-05 |
US5820869A (en) | 1998-10-13 |
EP1374910A1 (en) | 2004-01-02 |
DK0831921T3 (da) | 2004-04-26 |
EP0831921B1 (en) | 2004-01-02 |
HK1060847A1 (en) | 2004-08-27 |
CA2224257C (en) | 2005-08-16 |
JPH11506614A (ja) | 1999-06-15 |
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