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AR002848A1 - PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS PARTICULARLY USEFUL FOR THEIR ANTIBACTERIAL ACTION. - Google Patents

PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS PARTICULARLY USEFUL FOR THEIR ANTIBACTERIAL ACTION.

Info

Publication number
AR002848A1
AR002848A1 ARP960103597A AR10359796A AR002848A1 AR 002848 A1 AR002848 A1 AR 002848A1 AR P960103597 A ARP960103597 A AR P960103597A AR 10359796 A AR10359796 A AR 10359796A AR 002848 A1 AR002848 A1 AR 002848A1
Authority
AR
Argentina
Prior art keywords
antibacterial action
naftiridin
procedure
preparation
particularly useful
Prior art date
Application number
ARP960103597A
Other languages
Spanish (es)
Inventor
Darder Carlos Picornell
Hernandez Pedro Gonzalez
Gomez Antonio Cosme
Gonzales Maria Luisa Salas
Original Assignee
Sint Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sint Quimica Sa filed Critical Sint Quimica Sa
Publication of AR002848A1 publication Critical patent/AR002848A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención tiene por objeto un procedimiento para la obtención de naftiridinas de fórmula general (1), en las que R es igual a 3-amino-pirrolidin-1-ilo (tosufloxacino o ácido (RS)-7-(3-aminopirrolidin-1-il)-6- fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxílico(1a)) o a (1alfa,5alfa,6alfa)-6-amino-3-azabiciclo[3.1.0]hex-3-ilo (trovafloxacino o ácido 7-((1alfa,5alfa,6alfa)-6-amino-3-azabiciclo[3.1.0]hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridin-3- carboxílico (1b) y sus hidratos y sales respectivas, compuestos de síntesis coninteresantes propiedades terapéuticas que pertenecen a la familia de las fluoroquinolonas de acción antibacteriana.The present invention has as its object a process for obtaining naphthyridines of general formula (1), in which R is equal to 3-amino-pyrrolidin-1-yl (tosufloxacin or acid (RS) -7- (3-aminopyrrolidin -1-yl) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic (1a)) or a (1alpha, 5alpha, 6alpha ) -6-amino-3-azabicyclo [3.1.0] hex-3-yl (trovafloxacin or 7 - ((1alpha, 5alpha, 6alpha) -6-amino-3-azabicyclo [3.1.0] hex-3- acid yl) -6-fluoro-1- (2,4-difluorophenyl) -1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1b) and their respective hydrates and salts, synthetic compounds with interest therapeutic properties belonging to the family of fluoroquinolones with antibacterial action.

ARP960103597A 1995-07-27 1996-07-16 PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS PARTICULARLY USEFUL FOR THEIR ANTIBACTERIAL ACTION. AR002848A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09501512A ES2095809B1 (en) 1995-07-27 1995-07-27 PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS.

Publications (1)

Publication Number Publication Date
AR002848A1 true AR002848A1 (en) 1998-04-29

Family

ID=8291178

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103597A AR002848A1 (en) 1995-07-27 1996-07-16 PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS PARTICULARLY USEFUL FOR THEIR ANTIBACTERIAL ACTION.

Country Status (13)

Country Link
KR (1) KR970006303A (en)
AR (1) AR002848A1 (en)
CO (1) CO4700471A1 (en)
CZ (1) CZ204796A3 (en)
ES (1) ES2095809B1 (en)
FI (1) FI962852L (en)
GR (1) GR960100244A (en)
HU (1) HUP9602071A3 (en)
MX (1) MX9602953A (en)
NO (1) NO962906L (en)
PL (1) PL315423A1 (en)
PT (1) PT101897B (en)
SK (1) SK92396A3 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224150A (en) * 1987-04-08 1990-11-27 Chinoin Gyogyszer Es Vegyeszet Preparation of piperazinyl-substituted quinoline derivatives
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
WO1988010253A1 (en) * 1987-06-24 1988-12-29 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acid derivatives
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
ES2020786A6 (en) * 1990-07-19 1991-09-16 Inke Sa Procedure for obtaining (+)-7-(3-amino-1-pyrrolidinyl)-1- (2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acid and salts thereof
KR100221386B1 (en) * 1994-01-18 1999-09-15 디. 제이. 우드, 스피겔 알렌 제이 Process and intermediates for preparing naphthyridonecarboxylic acid salts

Also Published As

Publication number Publication date
HUP9602071A2 (en) 1997-03-28
PT101897B (en) 1999-07-30
KR970006303A (en) 1997-02-19
ES2095809A1 (en) 1997-02-16
FI962852L (en) 1997-01-28
HU9602071D0 (en) 1996-09-30
CO4700471A1 (en) 1998-12-29
FI962852A0 (en) 1996-07-15
PT101897A (en) 1997-06-30
HUP9602071A3 (en) 2000-03-28
PL315423A1 (en) 1997-02-03
ES2095809B1 (en) 1997-12-16
NO962906L (en) 1997-01-28
NO962906D0 (en) 1996-07-10
SK92396A3 (en) 1997-06-04
MX9602953A (en) 1997-06-28
CZ204796A3 (en) 1997-02-12
GR960100244A (en) 1997-03-31

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