AR001150A1 - Nuevo procedimiento para preparar derivados 2,3-dihidrobenzofuranol - Google Patents
Nuevo procedimiento para preparar derivados 2,3-dihidrobenzofuranolInfo
- Publication number
- AR001150A1 AR001150A1 AR33563396A AR33563396A AR001150A1 AR 001150 A1 AR001150 A1 AR 001150A1 AR 33563396 A AR33563396 A AR 33563396A AR 33563396 A AR33563396 A AR 33563396A AR 001150 A1 AR001150 A1 AR 001150A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- dihydrobenzofuranol
- derivatives
- 4alkyl
- 6alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un procedimiento para preparar derivados 2,3-dihidrobenzofuranol de fórmula (I), incluyendo estereoisómeros, enantiómeros y mezclas ópticamenteactivas y racémicas de los mismos, o sus sales farmacéuticamente aceptables, donde R2 es alquiloC1-4, siendo cada mitad R2 independientemente alquilo C1-4,o ambas mitades, cuando son tomadas junto con el átomo de carbono al que están unidas, forman una mitad hidrocarbilo cíclica C5-6; R4 es alquil C1-6; R5 es Ho C(O)R, siendo R,H o alquilo C1-9; R6 es alquilo C1-6; R7 es H o alquilo C1-6; X es COOR8, CH2OH, halometilo, C(O)A o CH2A; A es NR7R9, -N+R6R6R6-Q-,pirrolidino piperidino, morfolino o (II), R8 es H, alquilo C1-6 o -(CH2)m-A, siendo m 2, 3 ó 4; R9 es H, alquilo C1-4, o (III), nes 1, 2, 3 ó 4, p es 1, 2ó 3; R10 es H, alquilo C1-8, alquenilo C2-6, cicloalquilo C4-6, ciclohexilmetilo, hidroxialquilo (C2-6), dihidroxialquilo(C3-6), acil(C2-9)oxialquilo (C2-6), alcoxi(C1-4)alquilo (C1-6), -(CH2)(2-6)-O-(CH2)(2-4)OH,o (IV), siendo t 0, 1 ó 2, o pirimidinilo, con la condición de que, cuando Y seadistinto de H, entonces R10 sea H; Y es H, CH3 o COOR7; R11 es H, alcoxi C1-4, alquilo C1-4 o halógeno; R12 es ortoalcoxi C1-4, ortoalquilo C1-4 o p-halo, y Qesun haluro, un ión sulfonato (-)-SO3R1, siendo R1,H, alquilo C1-6, arilo o aralquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95400518 | 1995-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR001150A1 true AR001150A1 (es) | 1997-09-24 |
Family
ID=8221469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR33563396A AR001150A1 (es) | 1995-03-10 | 1996-03-05 | Nuevo procedimiento para preparar derivados 2,3-dihidrobenzofuranol |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5698696A (es) |
| EP (1) | EP0813530A1 (es) |
| JP (1) | JPH11501655A (es) |
| KR (1) | KR19980702883A (es) |
| AR (1) | AR001150A1 (es) |
| AU (1) | AU695575B2 (es) |
| CA (1) | CA2215105A1 (es) |
| FI (1) | FI973644A (es) |
| HU (1) | HUP9900377A3 (es) |
| IL (1) | IL117406A0 (es) |
| MX (1) | MX9706744A (es) |
| NO (1) | NO974155L (es) |
| NZ (2) | NZ303012A (es) |
| WO (1) | WO1996028437A1 (es) |
| ZA (1) | ZA961748B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL141414A0 (en) | 1998-09-10 | 2002-03-10 | Aventis Pharma Gmbh | Use of benzenesulfonyl (thio) ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl (thio) ureas in combination with beta-receptor blockers |
| DE602004019508D1 (de) | 2003-04-14 | 2009-04-02 | Nippon Soda Co | Diaminderivat, herstellungsverfahren und antioxidations-arzneimittel |
| JP4377881B2 (ja) | 2003-08-01 | 2009-12-02 | 日本曹達株式会社 | フェニルアゾール化合物、製造法および抗酸化薬 |
| HU230761B1 (hu) * | 2007-05-30 | 2018-03-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Új, szelektív 5HT6-receptorgátló benzofurán-származékok és eljárás előállításukra |
| US8366914B2 (en) * | 2007-10-15 | 2013-02-05 | Baker Hughes Incorporated | Multifunctional scavenger for hydrocarbon fluids |
| US9708547B2 (en) | 2007-10-15 | 2017-07-18 | Baker Hughes Incorporated | Water-based formulation of H2S/mercaptan scavenger for fluids in oilfield and refinery applications |
| EP2350035B1 (en) * | 2008-10-30 | 2016-01-13 | Archer Daniels Midland Co. | Reduction of hmf ethers with metal catalyst |
| US9938470B2 (en) | 2012-05-10 | 2018-04-10 | Baker Hughes, A Ge Company, Llc | Multi-component scavenging systems |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW199152B (es) * | 1990-11-01 | 1993-02-01 | Takeda Pharm Industry Co Ltd | |
| JP3150740B2 (ja) * | 1991-12-26 | 2001-03-26 | エーザイ株式会社 | ジヒドロベンゾフラン誘導体 |
| HUT68926A (en) * | 1992-04-06 | 1995-08-28 | Merrell Dow Phyarmaceuticals I | 2,3-dihydro-benzofuranol derivatives |
-
1996
- 1996-02-08 WO PCT/US1996/001838 patent/WO1996028437A1/en not_active Application Discontinuation
- 1996-02-08 AU AU49209/96A patent/AU695575B2/en not_active Ceased
- 1996-02-08 EP EP96905455A patent/EP0813530A1/en not_active Ceased
- 1996-02-08 NZ NZ303012A patent/NZ303012A/en unknown
- 1996-02-08 CA CA002215105A patent/CA2215105A1/en not_active Abandoned
- 1996-02-08 MX MX9706744A patent/MX9706744A/es unknown
- 1996-02-08 JP JP8527585A patent/JPH11501655A/ja active Pending
- 1996-02-08 KR KR1019970706291A patent/KR19980702883A/ko not_active Application Discontinuation
- 1996-02-08 HU HU9900377A patent/HUP9900377A3/hu unknown
- 1996-03-04 ZA ZA961748A patent/ZA961748B/xx unknown
- 1996-03-05 AR AR33563396A patent/AR001150A1/es unknown
- 1996-03-07 IL IL11740696A patent/IL117406A0/xx unknown
- 1996-03-07 US US08/612,366 patent/US5698696A/en not_active Expired - Fee Related
-
1997
- 1997-09-09 FI FI973644A patent/FI973644A/fi unknown
- 1997-09-09 NO NO974155A patent/NO974155L/no unknown
-
1998
- 1998-11-11 NZ NZ332750A patent/NZ332750A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI973644A0 (fi) | 1997-09-09 |
| CA2215105A1 (en) | 1996-09-19 |
| ZA961748B (en) | 1996-09-10 |
| NZ332750A (en) | 2000-01-28 |
| EP0813530A1 (en) | 1997-12-29 |
| IL117406A0 (en) | 1996-07-23 |
| NZ303012A (en) | 1999-04-29 |
| JPH11501655A (ja) | 1999-02-09 |
| MX9706744A (es) | 1997-11-29 |
| KR19980702883A (ko) | 1998-08-05 |
| WO1996028437A1 (en) | 1996-09-19 |
| HUP9900377A2 (hu) | 1999-05-28 |
| FI973644A (fi) | 1997-09-09 |
| NO974155L (no) | 1997-11-07 |
| NO974155D0 (no) | 1997-09-09 |
| US5698696A (en) | 1997-12-16 |
| AU4920996A (en) | 1996-10-02 |
| AU695575B2 (en) | 1998-08-13 |
| HUP9900377A3 (en) | 2000-03-28 |
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