gaia shamis
National Institutes of Health, NIAMS, Department Member
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests: Immunology, Flow Cytometry, Medical Microbiology, Virology, Neurochemistry, and 53 moreCell Migration, Membrane Proteins, Drug interactions, Enzyme Inhibitors, Polysaccharides, Gene expression, Cell Culture, Signal Transduction, HIV, Biological Sciences, Antioxidants, Synapse, Humans, Mutagenesis, Cell fusion, Mutation, Virus, Animals, NF-kappa B, Monoclonal Antibodies, Cell Viability, Proline, Glycoproteins, Solubility, Neuraminidase, Glycosylation, Neuroblastoma, Lipid Raft, Glucosamine, Protease Inhibitors, Time Factors, HeLa cells, Tumor necrosis factor-alpha, Pyridines, Transfection, Molecular weight, Alanine, Species Specificity, Imidazoles, Amino Acid Sequence, Structure activity Relationship, Recombinant Proteins, Cytoplasm, Neurosciences, Paper Chromatography, Medical Microbiology and Immunology, Interleukin, Acquired immunodeficiency syndrome, Oligosaccharides, Quantitative polymerase chain reaction, Giant Cells, Molecular Sequence Data, and Cell Membrane
Research Interests: Immunology, Flow Cytometry, Medical Microbiology, Virology, Neurochemistry, and 53 moreCell Migration, Membrane Proteins, Drug interactions, Enzyme Inhibitors, Polysaccharides, Gene expression, Cell Culture, Signal Transduction, HIV, Biological Sciences, Antioxidants, Synapse, Humans, Mutagenesis, Cell fusion, Mutation, Virus, Animals, NF-kappa B, Monoclonal Antibodies, Cell Viability, Proline, Glycoproteins, Solubility, Neuraminidase, Glycosylation, Neuroblastoma, Lipid Raft, Glucosamine, Protease Inhibitors, Time Factors, HeLa cells, Tumor necrosis factor-alpha, Pyridines, Transfection, Molecular weight, Alanine, Species Specificity, Imidazoles, Amino Acid Sequence, Structure activity Relationship, Recombinant Proteins, Cytoplasm, Neurosciences, Paper Chromatography, Medical Microbiology and Immunology, Interleukin, Acquired immunodeficiency syndrome, Oligosaccharides, Quantitative polymerase chain reaction, Giant Cells, Molecular Sequence Data, and Cell Membrane
Research Interests:
Research Interests:
Research Interests:
Research Interests:
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called... more
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching for pathogen-derived pMHC. Synapses are induced by T cell receptor (TCR) interactions with agonist pMHC under specific conditions and correlate with robust immune responses that generate effector and memory T cells. High-resolution imaging has revealed that the synapse is highly coordinated, integrating cell adhesion, TCR recognition of pMHC complexes, and an array of activating and inhibitory ligands to promote or prevent T cell signaling. In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward.