Papers by Stephen J Gotts
Brain : a journal of neurology, Jan 22, 2015
Schizophrenia is increasingly recognized as a neurodevelopmental disorder with altered connectivi... more Schizophrenia is increasingly recognized as a neurodevelopmental disorder with altered connectivity among brain networks. In the current study we examined large-scale network interactions in childhood-onset schizophrenia, a severe form of the disease with salient genetic and neurobiological abnormalities. Using a data-driven analysis of resting-state functional magnetic resonance imaging fluctuations, we characterized data from 19 patients with schizophrenia and 26 typically developing controls, group matched for age, sex, handedness, and magnitude of head motion during scanning. This approach identified 26 regions with decreased functional correlations in schizophrenia compared to controls. These regions were found to organize into two function-related networks, the first with regions associated with social and higher-level cognitive processing, and the second with regions involved in somatosensory and motor processing. Analyses of across- and within-network regional interactions r...
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Cortex, 2015
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Molecular Autism, 2015
Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortic... more Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. ClinicalTrials.gov NCT01031407.
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Neuropsychopharmacology
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Psychonomic Bulletin & Review
Incremental learning models of long-term perceptual and conceptual knowledge hold that neural rep... more Incremental learning models of long-term perceptual and conceptual knowledge hold that neural representations are gradually acquired over many individual experiences via Hebbian-like activity-dependent synaptic plasticity across cortical connections of the brain. In such models, variation in task relevance of information, anatomical constraints, and the statistics of sensory inputs and motor outputs lead to qualitative alterations in the nature of representations that are acquired. Here, I discuss the proposal that behavioral repetition priming and neural repetition suppression effects are empirical markers of incremental learning in the cortex, and I review a variety of literatures that both support and challenge this position. I focus discussion on a recent fMRI-adaptation study from our lab that shows decoupling of experience-dependent changes in neural tuning, priming, and repetition suppression, with representational changes that appear to work counter to the explicit task dema...
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PsycEXTRA Dataset, 2004
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Frontiers in human neuroscience, 2010
Experience with visual objects leads to later improvements in identification speed and accuracy (... more Experience with visual objects leads to later improvements in identification speed and accuracy ("repetition priming"), but generally leads to reductions in neural activity in single-cell recording studies in animals and fMRI studies in humans. Here we use event-related, source-localized MEG (ER-SAM) to evaluate the possibility that neural activity changes related to priming in occipital, temporal, and prefrontal cortex correspond to more temporally coordinated and synchronized activity, reflected in local increases in the amplitude of low-frequency activity fluctuations (i.e. evoked power) that are time-locked to stimulus onset. Subjects (N = 17) identified pictures of objects that were either novel or repeated during the session. Tests in two separate low-frequency bands (theta/alpha: 5-15 Hz; beta: 15-35 Hz) revealed increases in evoked power (5-15 Hz) for repeated stimuli in the right fusiform gyrus, with the earliest significant increases observed 100-200 ms after sti...
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Neuropsychologia, Jan 7, 2014
Recent experience identifying objects leads to later improvements in both speed and accuracy (&qu... more Recent experience identifying objects leads to later improvements in both speed and accuracy ("repetition priming"), along with simultaneous reductions of neural activity ("repetition suppression"). A popular interpretation of these joint behavioral and neural phenomena is that object representations become perceptually "sharper" with stimulus repetition, eliminating cells that are poorly stimulus-selective and responsive and reducing support for competing representations downstream. Here, we test this hypothesis in an fMRI-adaptation experiment using pictures of objects. Prior to fMRI, participants repeatedly named a set of object pictures. During fMRI, participants viewed adaptation sequences composed of rapidly repeated objects (3-6 repetitions over several seconds) that were either named previously or that were new for the fMRI session, followed by single "deviant" object pictures used to measure recovery from adaptation and that shared a ...
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Seminars in Speech and Language, 2004
Aphasic patients make a variety of speech errors, including perseverations, in tasks that involve... more Aphasic patients make a variety of speech errors, including perseverations, in tasks that involve a linguistic component. What do perseverative and other errors imply about the nature of the neurologically damaged and intact language systems? Here we discuss the insights into the mechanisms of aphasic perseveration afforded by connectionist models. As a base for discussion, we review the Plaut and Shallice model of optic aphasic errors in object naming, which relies primarily on short-term learning mechanisms to produce perseverations. We then point out limitations of the model in addressing more recent data collected on aphasic perseveration and explain how incorporating information about the interaction of neuromodulatory systems and learning in the brain may help to overcome these limitations.
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Science, 2009
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Neuropsychologia, 2002
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Journal of Vision, 2011
ABSTRACT
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Journal of Neuroscience Methods, 2013
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Cognitive, Affective, & Behavioral Neuroscience, 2002
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Cerebral Cortex, 2011
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Papers by Stephen J Gotts