Open Access by Mange Ram Yadav
Bentham Science Publishers
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflam... more Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.
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Papers by Mange Ram Yadav
Neuromethods, 2017
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Indian drugs, 2002
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Indian drugs, 2003
... INIST-CNRS. 2, Allée du Parc de Brabois CS 10310 F-54519 Vandoeuvre-lès-Nancy Cedex France Ph... more ... INIST-CNRS. 2, Allée du Parc de Brabois CS 10310 F-54519 Vandoeuvre-lès-Nancy Cedex France Phone: +33 (0)3 83 50 46 64 Fax: +33 (0)3 83 50 46 66. ... Auteur(s) / Author(s). SARATHY KP ; GIRIDHAR R. ; YADAV MR ; Résumé / Abstract. ...
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Journal of the American Chemical Society, 2006
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ChemInform, 1990
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ChemInform, 2010
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Bioorganic & Medicinal Chemistry, 2012
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Molecular Diversity, 2021
In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[... more In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[3-(benzimidazol-2-yl-amino)phenyl]amine and N-[3-(benzoxazol-2-ylamino)phenyl]amine derivatives. In vitro cytotoxicity assay of 26 selected compounds was carried out at National Cancer Institute (NCI), USA. Out of them, compounds 10e (NSC D-762842/1) and 11s (NSC D-764942/1) have shown remarkable cytotoxicity with GI50 values ranging between "0.589-14.3 µM" and "0.276-12.3 µM," respectively, in the representative nine subpanels of human tumor cell lines. Further, flow cytometry analysis demonstrated that compound 10e exerted cell cycle arrest at G2/M phase and showed dose-dependent enhancement in apoptosis in K-562 leukemia cancer cells.
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ChemInform, 2010
ABSTRACT
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ChemInform, 2010
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European Journal of Medicinal Chemistry, 2006
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ChemInform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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ChemInform, 2010
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ChemInform, 2010
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Indian journal of experimental biology, 1996
Gas liquid chromatographic analysis of fixed oil of O. sanctum revealed the presence of five fatt... more Gas liquid chromatographic analysis of fixed oil of O. sanctum revealed the presence of five fatty acids (stearic, palmitic, oleic, linoleic and linolenic acids). The triglyceride fraction of the oil showed higher protection compared to fixed oil against carrageenam-induced paw edema and acetic acid-induced writhings in rats and mice, respectively. The pharmacological activity of the fixed oil could be attributed to its triglyceride fraction or the fatty acids.
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Bollettino chimico farmaceutico, 2004
A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ... more A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ion-pair of chloroquine with pamoic acid. Various parameters involved in the formulation of a stable and palatable suspension have been optimized. The suspension was characterized for particle size analysis, viscosity, physical and chemical stability and taste. Release of chloroquine from the ion-pair conducted as dissolution rate studies in simulated gastric media showed near to 100% release instantaneously. In-vivo bioavailability study conducted in albino rats indicated comparable bioavailability of chloroquine from the suspension with that of chloroquine phosphate syrup taken as standard. Stability study conducted over a period of 3 months showed the intactness of the ion-pair and the tasteless behavior of the suspension throughout the period of storage.
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Progress in Medicinal Chemistry, 1979
Page 47. Progress in Medicinal ChemistryVol. 16, edited by GP Ellis and GB West © Elsevier/North... more Page 47. Progress in Medicinal ChemistryVol. 16, edited by GP Ellis and GB West © Elsevier/North-Holland Biomedical Press1979 2 Heterosteroids and Drug Research HARKISHAN SINGH, M. Pharm., Ph. D. VIJAY K. KAPOOR, M. Pharm., Ph. ...
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Mini-Reviews in Medicinal Chemistry, 2007
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Journal of Advanced Pharmaceutical Technology & Research, 2013
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Open Access by Mange Ram Yadav
Papers by Mange Ram Yadav