Kanchana Srisawat

We examined muscle proteostasis in obese insulin-resistant (OIR) individuals to determine whether endurance exercise could positively influence proteome dynamics in this population. Male OIR (n = 3) and lean, healthy controls (LHC; n = 4) were recruited and underwent a 14-d measurement protocol of daily deuterium oxide (D2O) consumption and serial biopsies of vastus lateralis muscle. The OIR group then completed 10-weeks of high-intensity interval training (HIIT), encompassing 3 sessions per week of cycle ergometer exercise with 1 min intervals at 100 % maximum aerobic power (Wmax) interspersed by 1 min recovery periods. The number of intervals per session progressed from 4 to 8, and during weeks 8-10 the 14-d measurement protocol was repeated. The abundance and turnover rates of 880 and 301 proteins, respectively, were measured. OIR and LHC muscle exhibited 352 differences (p< 0.05, false discovery rate (p< 0.05) differences in protein turnover. OIR muscle was enriched with m...

This pilot experiment examines if a loss in muscle proteostasis occurs in people with obesity and whether endurance exercise positively influences either the abundance profile or turnover rate of proteins in this population. Men with (n = 3) or without (n = 4) obesity were recruited and underwent a 14-d measurement protocol of daily deuterium oxide (D2O) consumption and serial biopsies of vastus lateralis muscle. Men with obesity then completed 10-weeks of high-intensity interval training (HIIT), encompassing 3 sessions per week of cycle ergometer exercise with 1 min intervals at 100 % maximum aerobic power interspersed by 1 min recovery periods. The number of intervals per session progressed from 4 to 8, and during weeks 8-10 the 14-d measurement protocol was repeated. Proteomic analysis detected 352 differences (p < 0.05, false discovery rate < 5%) in protein abundance and 19 (p < 0.05) differences in protein turnover, including components of the ubiquitin-proteasome syst...

Abstract: The genus Cassia (family Leguminosae, subfamily Caesalpinioideae, tribe Cassieae, subtribe Cassiinae) is a tropical plant group of trees, shrubs, or herbs. These plants are so useful from their herbal medical property and their quality woods. According to Flora of Thailand (1), there are 21 species of Cassia found in the country. However, this taxonomic classification does not agree with those of other

Background Bipolar disorder (BD) is a serious mood disorder which affects approximately 1-3% of the population. It has a major impact on social functioning and is associated with considerable cost to healthcare systems around the world. Although genetic factors play a role in the etiology of BD, non-genetic factors are also likely to be important. Aim To conduct a systematic review of the literature on non-genetic risk factors for bipolar disorder. Methodology Searches were conducted in MEDLINE and PsycINFO for the period up to December 2013 and limited to English language and peer-reviewed publications. Eligibility criteria included bipolar disorder (BD) diagnosed by either the Diagnostic and Statistical Manual of Mental Disorder (DSM III, IV, IV-TR) or the International Classification of Disease (ICD 8, 9, 10) systems. Our search terms covered two categories including 14 synonyms for bipolar disorder and 50 possible risk factor areas. Result Eight hundred and one studies were obta...