(Q47140692)

English

mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons

scientific article published on 30 December 2016

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Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5577393

mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons (English)

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5577393

Alzheimer's disease

0 references

insulin resistance

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Han-Kyu Lee

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Bumsup Kwon

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Cynthia A Lemere

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Suzanne de la Monte

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Kyohei Itamura

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Henry W Querfurth

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

publication date

30 December 2016

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5577393

Journal of Alzheimer's Disease

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

56

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

3

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1015-1036

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin

1 reference

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23 May 2018

mTOR in Brain Physiology and Pathologies

1 reference

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1 reference

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Abnormal Glucose Metabolism in Alzheimer's Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

1 reference

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23 May 2018

Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells

1 reference

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mTor mediates tau localization and secretion: Implication for Alzheimer's disease

1 reference

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23 May 2018

Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology

1 reference

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Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease

1 reference

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23 May 2018

Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature

1 reference

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Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.

1 reference

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23 May 2018

Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells

1 reference

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23 May 2018

mTor is a signaling hub in cell survival: a mass-spectrometry-based proteomics investigation

1 reference

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23 May 2018

The role of autophagy in neurodegenerative disease

1 reference

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23 May 2018

PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease

1 reference

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23 May 2018

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.

1 reference

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23 May 2018

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.

1 reference

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23 May 2018

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

1 reference

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23 May 2018

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.

1 reference

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23 May 2018

mTOR signaling in growth control and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

23 May 2018

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

1 reference

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23 May 2018

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

1 reference

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23 May 2018

Roles of AMP-activated protein kinase in Alzheimer's disease.

1 reference

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23 May 2018

mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes

1 reference

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23 May 2018

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

1 reference

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23 May 2018

The role of mTOR signaling in Alzheimer disease

1 reference

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23 May 2018

Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons

1 reference

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23 May 2018

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

1 reference

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23 May 2018

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.

1 reference

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23 May 2018

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

1 reference

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23 May 2018

mTORC2 is required for proliferation and survival of TSC2-null cells

1 reference

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23 May 2018

Activation of mTORC2 by association with the ribosome

1 reference

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23 May 2018

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

1 reference

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23 May 2018

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

1 reference

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23 May 2018

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

1 reference

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23 May 2018

Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

1 reference

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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

1 reference

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23 May 2018

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

1 reference

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23 May 2018

Protein homeostasis and aging in neurodegeneration

1 reference

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23 May 2018

AMPK inhibition in health and disease

1 reference

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23 May 2018

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

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23 May 2018

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

1 reference

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23 May 2018

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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23 May 2018

SIRT1 negatively regulates the mammalian target of rapamycin

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23 May 2018

Direct control of mitochondrial function by mTOR.

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23 May 2018

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

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23 May 2018

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

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23 May 2018

mTOR signaling: at the crossroads of plasticity, memory and disease

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23 May 2018

Alzheimer's disease is type 3 diabetes-evidence reviewed

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23 May 2018

TOR complex 2: a signaling pathway of its own.

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23 May 2018

Insulin resistance and Alzheimer's disease

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Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.

1 reference

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23 May 2018

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

1 reference

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23 May 2018

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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23 May 2018

AMPK in Health and Disease

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23 May 2018

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

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23 May 2018

mTOR-dependent signalling in Alzheimer's disease

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23 May 2018

The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid

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23 May 2018

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

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23 May 2018

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

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23 May 2018

p70 S6 kinase and tau in Alzheimer's disease.

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23 May 2018

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

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23 May 2018

AMPK phosphorylation of raptor mediates a metabolic checkpoint

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23 May 2018

Role of mTOR in physiology and pathology of the nervous system

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23 May 2018

Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

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23 May 2018

Autophagy is activated for cell survival after endoplasmic reticulum stress

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23 May 2018

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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23 May 2018

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

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23 May 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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23 May 2018

The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

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23 May 2018

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

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23 May 2018

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

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23 May 2018

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

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23 May 2018

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

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23 May 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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23 May 2018

Restraining PI3K: mTOR signalling goes back to the membrane.

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23 May 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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23 May 2018

Upstream and downstream of mTOR

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23 May 2018

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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23 May 2018

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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23 May 2018

TSC2 mediates cellular energy response to control cell growth and survival

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23 May 2018

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

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23 May 2018

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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23 May 2018

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

23 May 2018

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

23 May 2018

Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

23 May 2018

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Isolation and culture of neurons and astrocytes from the mouse brain cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Rapamycin pre-treatment protects against apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Role of protein kinase B in Alzheimer's neurofibrillary pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5577393

15 August 2018

Intraneuronal -Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

1 reference

https://api.crossref.org/works/10.3233%2FJAD-161029

21 January 2018

Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28035937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3233/JAD-161029

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28035937%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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