(Q46440747)

22 December 2017

title

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease (English)

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22 December 2017

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Li Chen

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22 December 2017

Mel B Feany

series ordinal

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22 December 2017

language of work or name

English

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publication date

17 April 2005

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22 December 2017

published in

Nature Neuroscience

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22 December 2017

volume

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22 December 2017

issue

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22 December 2017

page(s)

657-663

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22 December 2017

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

cites work

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7 January 2021

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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alpha-Synuclein locus triplication causes Parkinson's disease

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Alpha-synuclein in Lewy bodies

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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7 January 2021

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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7 January 2021

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

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7 January 2021

Accumulation of phosphorylated alpha-synuclein in aging human brain

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7 January 2021

Protein aggregation and neurodegenerative disease

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7 January 2021

A Drosophila model of Parkinson's disease

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7 January 2021

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

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7 January 2021

Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tau

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7 January 2021

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

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7 January 2021

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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7 January 2021

Isolation of Drosophila genes encoding G protein-coupled receptor kinases

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7 January 2021

Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster

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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

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7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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7 January 2021

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

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7 January 2021

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

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7 January 2021

Neurotoxicity of beta-amyloid and prion peptides.

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7 January 2021

alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

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7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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7 January 2021

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

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7 January 2021

Mechanism of prion propagation: amyloid growth occurs by monomer addition

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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7 January 2021

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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7 January 2021

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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7 January 2021

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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7 January 2021

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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7 January 2021

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

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7 January 2021

Rapid purification and analysis of alpha-synuclein proteins: C-terminal truncation promotes the conversion of alpha-synuclein into a protease-sensitive form in Escherichia coli

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7 January 2021

Identifiers

DOI

10.1038/NN1443

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22 December 2017

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22 December 2017