(Q33292483)

25 July 2017

title

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. (English)

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25 July 2017

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spinocerebellar ataxia

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Summer F Acevedo

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Harry T Orr

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Huda Y Zoghbi

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Hung-Kai Chen

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25 July 2017

Pedro Fernandez-Funez

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25 July 2017

Yung C Lam

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25 July 2017

Michael D Kaytor

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25 July 2017

Michael H Fernandez

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25 July 2017

Alastair Aitken

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25 July 2017

Efthimios M C Skoulakis

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25 July 2017

Juan Botas

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25 July 2017

language of work or name

English

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publication date

1 May 2003

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25 July 2017

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25 July 2017

volume

113

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25 July 2017

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25 July 2017

page(s)

457-468

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Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain

25 July 2017

cites work

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

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The phosphoinositide 3-kinase pathway

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Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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Animal models of PD: pieces of the same puzzle?

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Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

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Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

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Identification of genes that modify ataxin-1-induced neurodegeneration.

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14-3-3 proteins: structure, function, and regulation

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14-3-3zeta is an effector of tau protein phosphorylation

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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

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Signaling--2000 and beyond

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Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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7 January 2021

The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit. Evidence for a dynamic role in subunit stabilization

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14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains

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Aberrant protein deposition and neurological disease

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Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

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Neurodegenerative tauopathies

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The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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7 January 2021

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

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7 January 2021

14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

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7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

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7 January 2021

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

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7 January 2021

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

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7 January 2021

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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7 January 2021

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

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7 January 2021

Mouse and fly models of neurodegeneration

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7 January 2021

Glutamine repeats and neurodegeneration

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7 January 2021

10.1016/S0092-8674(03)00349-0

Identifiers

DOI

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25 July 2017

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