(Q42606895)

3 November 2017

title

A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation (English)

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3 November 2017

Chang-sheng S Chang

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3 November 2017

Riccardo Olcese

series ordinal

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3 November 2017

Richard W Olsen

series ordinal

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3 November 2017

language of work or name

English

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publication date

25 August 2003

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Journal of Biological Chemistry

3 November 2017

published in

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3 November 2017

volume

278

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3 November 2017

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3 November 2017

page(s)

42821-42828

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The molecular mechanism of action of general anesthetics: structural aspects of interactions with GABA(A) receptors.

3 November 2017

cites work

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Modulation of GABA(A) receptor channel gating by pentobarbital

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The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

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Etomidate potentiation of GABAA receptor gated current depends on the subunit composition.

21 January 2018

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Modulation of the GABA receptor complex by a steroid anaesthetic

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21 January 2018

GABAA receptor channels

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Evolutionary history of the ligand-gated ion-channel superfamily of receptors

21 January 2018

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Nicotinic receptors at the amino acid level

21 January 2018

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The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.

21 January 2018

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Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

21 January 2018

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Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants

21 January 2018

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Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations

21 January 2018

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The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis

21 January 2018

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Differential expression of the neuronal acetylcholine receptor alpha 2 subunit gene during chick brain development

21 January 2018

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GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital

21 January 2018

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

21 January 2018

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Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure

21 January 2018

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Structure and gating mechanism of the acetylcholine receptor pore

21 January 2018

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A novel allosteric modulatory site on the GABAA receptor beta subunit

21 January 2018

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Subunit composition, distribution and function of GABA(A) receptor subtypes

21 January 2018

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Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

21 January 2018

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The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

21 January 2018

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Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

21 January 2018

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Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

21 January 2018

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Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating

21 January 2018

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Differential sensitivity of recombinant GABA(A) receptors expressed in Xenopus oocytes to modulation by topiramate

21 January 2018

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Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid

21 January 2018

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The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations

21 January 2018

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Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones

21 January 2018

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Nature of the 5' residue in the M2 domain affects function of the human alpha 1 beta 1 GABAA receptor

21 January 2018

1 reference

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Mutant human alpha(1)beta(1)(T262Q) GABA(A) receptors are directly activated but not modulated by pentobarbital

21 January 2018

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A sequence and structural study of transmembrane helices

21 January 2018

1 reference

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Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306978200

Two invariant tryptophans on the alpha1 subunit define domains necessary for GABA(A) receptor assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306978200

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306978200

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306978200

Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306978200

21 January 2018

Identifiers

DOI

10.1074/JBC.M306978200

1 reference

3 November 2017

1 reference