(Q33537099)

27 July 2017

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title

The molecular mechanism of action of general anesthetics: structural aspects of interactions with GABA(A) receptors. (English)

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27 July 2017

Olsen RW

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27 July 2017

publication date

1 November 1998

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27 July 2017

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27 July 2017

volume

100-101

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27 July 2017

page(s)

193-201

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GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital

27 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

A Structural Determinant of Desensitization and Allosteric Regulation by Pentobarbitone of the GABA A Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

GABAA receptor subtypes: ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Predicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

GABAA receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Which GABAA-receptor subtypes really occur in the brain?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Modulation of GABAA receptor binding in human brain by neuroactive steroids: species and brain regional differences

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Allosteric Actions of Central Nervous System Depressants Including Anesthetics on Subtypes of the Inhibitory ?-Aminobutyric AcidAReceptor?Chloride Channel Complex

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Functional domains of GABAA receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

A novel allosteric modulatory site on the GABAA receptor beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Decreased agonist sensitivity of human GABA(A) receptors by an amino acid variant, isoleucine to valine, in the alpha1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

Delta subunit inhibits neurosteroid modulation of GABAA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2898%2900185-4

7 January 2021

10.1016/S0378-4274(98)00185-4

Identifiers

DOI

1 reference

27 July 2017

1 reference