(Q40950086)

25 September 2017

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title

Sphingolipid metabolites: members of a new class of lipid second messengers (English)

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25 September 2017

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S Spiegel

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25 September 2017

S Milstien

series ordinal

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25 September 2017

publication date

1 August 1995

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Journal of Membrane Biology

25 September 2017

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inferred from page(s)

published in

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25 September 2017

volume

146

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25 September 2017

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25 September 2017

page(s)

225-237

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Bimodal distribution of phosphatidic acid phosphohydrolase in NG108-15 cells. Modulation by the amphiphilic lipids oleic acid and sphingosine

25 September 2017

cites work

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12 December 2020

Gangliosides as bimodal regulators of cell growth

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12 December 2020

Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts

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12 December 2020

Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line

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12 December 2020

Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging

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12 December 2020

An alternative pathway for the enzymatic synthesis of sphingomyelin.

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12 December 2020

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

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12 December 2020

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal

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12 December 2020

Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors.

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12 December 2020

Cell regulation by sphingosine and more complex sphingolipids

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12 December 2020

Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases

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12 December 2020

The different effects of sphingosine on diacylglycerol kinase isozymes in Jurkat cells, a human T-cell line.

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12 December 2020

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate

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12 December 2020

Intracellular calcium release mediated by sphingosine derivatives generated in cells

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12 December 2020

Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells

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12 December 2020

Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine.

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12 December 2020

Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases

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12 December 2020

Signaling through phosphatidylcholine breakdown.

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12 December 2020

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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12 December 2020

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

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12 December 2020

Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells

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12 December 2020

Control of transcription factors by signal transduction pathways: the beginning of the end

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12 December 2020

Stereospecificities in the metabolic reactions of the four isomeric sphinganines (dihydrosphingosines) in rat liver

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12 December 2020

Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C.

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12 December 2020

The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1.

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12 December 2020

Metabolism of sphingosine bases. IX. Degradation in vitro of dihydrospingosine and dihydrospingosine phosphate to palmitaldehyde and ethanolamine phosphate

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12 December 2020

Peptide growth factors are multifunctional

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12 December 2020

Sphingosine inhibits calmodulin-dependent enzymes

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12 December 2020

Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells

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12 December 2020

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor

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12 December 2020

Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport

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12 December 2020

Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors

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12 December 2020

Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid.

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12 December 2020

Sphingolipid base phosphorylation by cell-free preparations from Tetrahymena pyriformis

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12 December 2020

Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship

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12 December 2020

What is the fate of diacylglycerol produced at the Golgi apparatus?

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12 December 2020

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

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12 December 2020

A cytoplasmic protein inhibits the GTPase activity of H-Ras in a phospholipid-dependent manner

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12 December 2020

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

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12 December 2020

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness

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12 December 2020

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases

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12 December 2020

Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization

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12 December 2020

Mechanisms of growth control in normal and malignant breast epithelium

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12 December 2020

Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme

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12 December 2020

The effects of sphingosine on sarcoplasmic reticulum membrane calcium release

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12 December 2020

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation

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12 December 2020

Inhibition of the insulin receptor tyrosine kinase by sphingosine

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12 December 2020

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine. Dual action of sphingosine in diacylglycerol signal termination

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12 December 2020

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

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12 December 2020

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

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12 December 2020

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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12 December 2020

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway

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12 December 2020

Regulation by sphingomyelinase and sphingosine of Ca2+ signals elicited by CD3 monoclonal antibody, thapsigargin, or ionomycin in the Jurkat T cell line.

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12 December 2020

Sphingosine stimulates calcium mobilization in rat parotid acinar cells

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12 December 2020

Early signals in the mitogenic response

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12 December 2020

Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells.

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12 December 2020

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts

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12 December 2020

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells

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12 December 2020

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts

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12 December 2020

The role of sphingosine in cell growth regulation and transmembrane signaling

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12 December 2020

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells

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12 December 2020

Activation of casein kinase II by sphingosine.

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12 December 2020

Ras GTPase-activating protein physically associates with mitogenically active phospholipids

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12 December 2020

Sphingosine mobilizes intracellular calcium in human neutrophils

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12 December 2020

Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate

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12 December 2020

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

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12 December 2020

Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover

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12 December 2020

Enzymes of ceramide biosynthesis

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12 December 2020

Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells

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12 December 2020

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12 December 2020

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

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12 December 2020

Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling.

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12 December 2020

Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis

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12 December 2020

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

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12 December 2020

The sphingomyelin cycle and the second messenger function of ceramide.

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12 December 2020

Signal transduction by the platelet-derived growth factor receptor

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12 December 2020

Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts

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12 December 2020

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

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12 December 2020

Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction

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12 December 2020

A phosphatidic acid-sensitive intracellular pool of calcium is released by anti-CD3 in Jurkat T cells

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12 December 2020

MAP kinases: charting the regulatory pathways

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12 December 2020

Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver

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12 December 2020

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

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12 December 2020

Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells

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12 December 2020

Phospholipase D activation by the mitogens platelet-derived growth factor and 12-O-tetradecanoylphorbol 13-acetate in NIH-3T3 cells

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12 December 2020

Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C

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12 December 2020

Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.

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12 December 2020

Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

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12 December 2020

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cell

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12 December 2020

The effect of sphingosine and phorbol ester on the signal transduction enzymes and fibronectin release in cell culture

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12 December 2020

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

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12 December 2020

Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

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12 December 2020

Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note

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12 December 2020

Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.

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12 December 2020

Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells

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12 December 2020

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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12 December 2020

Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine

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12 December 2020

Functions of sphingolipids and sphingolipid breakdown products in cellular regulation

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12 December 2020

Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling

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12 December 2020

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

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12 December 2020

D-erythro-sphingosine lowers 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Chinese hamster ovary cells

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12 December 2020

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation

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12 December 2020

Properties and specificities of sphingosine kinase from blood platelets

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12 December 2020

Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells

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12 December 2020

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

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12 December 2020

The effect of GTPase activating protein upon ras is inhibited by mitogenically responsive lipids

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12 December 2020

Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts

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12 December 2020

Inositol trisphosphate and calcium signalling

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12 December 2020

Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines

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12 December 2020

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver

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12 December 2020

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

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12 December 2020

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol

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12 December 2020

Sphingosine inhibits sphingomyelinase-induced cholesteryl ester formation in cultured fibroblasts.

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12 December 2020

How is the level of free arachidonic acid controlled in mammalian cells?

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12 December 2020

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

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12 December 2020

Identifiers

DOI

10.1007/BF00233943

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25 September 2017

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