(Q40942994)

25 September 2017

title

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase (English)

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25 September 2017

Durkin JT

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25 September 2017

Murthy S

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25 September 2017

Husten EJ

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25 September 2017

Trusko SP

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25 September 2017

Savage MJ

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25 September 2017

Rotella DP

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25 September 2017

Greenberg BD

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25 September 2017

Siman R

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25 September 2017

language of work or name

English

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publication date

1 July 1999

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Journal of Biological Chemistry

25 September 2017

published in

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25 September 2017

volume

274

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25 September 2017

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25 September 2017

page(s)

20499-20504

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Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease

25 September 2017

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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21 January 2018

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

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Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation

21 January 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

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Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein

21 January 2018

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Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

21 January 2018

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Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

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Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

21 January 2018

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Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

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Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

21 January 2018

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Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ42 in parenchymal amyloid plaques and both Aβ40 and Aβ42 in cerebrovascular deposits

21 January 2018

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Overexpression of a COOH-terminal fragment of β-amyloid precursor protein in HeLa cells results in accumulation in a pre-Golgi compartment and generation of an Aβ-like fragment

21 January 2018

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Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

21 January 2018

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The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

21 January 2018

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Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

21 January 2018

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Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung

21 January 2018

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Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

21 January 2018

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Mutations in the transmembrane domain of APP altering gamma-secretase specificity

21 January 2018

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Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

21 January 2018

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Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.29.20499

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25 September 2017

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