(Q34289409)

1 August 2017

title

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway (English)

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early-onset Alzheimer's disease

1 August 2017

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Haass C

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1 August 2017

Lemere CA

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1 August 2017

Capell A

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1 August 2017

Citron M

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1 August 2017

Seubert P

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1 August 2017

Schenk D

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1 August 2017

Lannfelt L

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1 August 2017

Selkoe DJ

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1 August 2017

language of work or name

English

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publication date

1 December 1995

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

1291-1296

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Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

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https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Genetic and molecular advances in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

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7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation

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https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

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7 January 2021

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

1 reference

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7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

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7 January 2021

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1 reference

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7 January 2021

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Microtubules, membrane traffic, and cell organization

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Identification of two lysosomal membrane glycoproteins

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Generation of amyloid β protein from its precursor is sequence specific

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

1 reference

https://api.crossref.org/works/10.1038%2FNM1295-1291

7 January 2021

Identifiers

DOI

10.1038/NM1295-1291

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1 August 2017

1 reference