(Q40783205)

23 September 2017

title

Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. (English)

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23 September 2017

Turenne GA

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23 September 2017

Paul P

series ordinal

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23 September 2017

Laflair L

series ordinal

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23 September 2017

Price BD

series ordinal

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23 September 2017

language of work or name

English

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publication date

1 August 2001

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23 September 2017

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23 September 2017

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23 September 2017

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23 September 2017

page(s)

5100-5110

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Regulation of p53 function and stability by phosphorylation

23 September 2017

cites work

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Caffeine inhibits the checkpoint kinase ATM

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

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The role of ATM in DNA damage responses and cancer

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1

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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

21 January 2018

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Mdm2 promotes the rapid degradation of p53

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DNA-damage-inducible p53 activity in SV40-transformed cells

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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Regulation of p53 in response to ionizing radiation in ataxia telangiectasia fibroblasts

21 January 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

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The influence of SV40 immortalization of human fibroblasts on p53-dependent radiation responses

21 January 2018

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Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

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Fragments of ATM which have dominant-negative or complementing activity

21 January 2018

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Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

21 January 2018

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen

21 January 2018

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Mitotic DNA damage and replication checkpoints in yeast

21 January 2018

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The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

21 January 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

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DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

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Cleavage and inactivation of ATM during apoptosis.

21 January 2018

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Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation

21 January 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

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Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

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Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta

21 January 2018

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Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

21 January 2018

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

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Recombinant ATM protein complements the cellular A-T phenotype

21 January 2018

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Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

21 January 2018

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Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum

21 January 2018

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Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay

21 January 2018

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7 January 2021

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

On the nature of a defect in cells from individuals with ataxia-telangiectasia

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

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7 January 2021

Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

Relationship between gamma-ray-induced G2/M delay and cellular radiosensitivity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

DNA damage and checkpoint pathways: molecular anatomy and interactions with repair

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204665

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204665

1 reference

Dimensions Publication ID

23 September 2017

1023864727

0 references

1 reference