(Q37848053)

24 August 2017

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title

Potential therapeutic uses of BDNF in neurological and psychiatric disorders (English)

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24 August 2017

Mark H Tuszynski

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24 August 2017

Alan H Nagahara

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24 August 2017

publication date

1 March 2011

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Nature Reviews Drug Discovery

24 August 2017

published in

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24 August 2017

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24 August 2017

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24 August 2017

page(s)

209-219

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Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

24 August 2017

cites work

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Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor

31 March 2020

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Regulation of cell survival by secreted proneurotrophins

31 March 2020

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Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

31 March 2020

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Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth

31 March 2020

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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

31 March 2020

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The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

31 March 2020

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Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

31 March 2020

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Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.

31 March 2020

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BDNF release from single cells elicits local dendritic growth in nearby neurons

31 March 2020

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Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

31 March 2020

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Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

31 March 2020

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Role for brain-derived neurotrophic factor in learning and memory

31 March 2020

1 reference

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

31 March 2020

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Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory

31 March 2020

1 reference

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

31 March 2020

1 reference

Molecular therapy of obesity and diabetes by a physiological autoregulatory approach

31 March 2020

1 reference

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

31 March 2020

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Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

31 March 2020

1 reference

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

31 March 2020

1 reference

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

31 March 2020

1 reference

Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group

31 March 2020

1 reference

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

31 March 2020

1 reference

Neuropathological stageing of Alzheimer-related changes

31 March 2020

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Synaptic and neuritic alterations during the progression of Alzheimer's disease

31 March 2020

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Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system

31 March 2020

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Anterograde transport of brain-derived neurotrophic factor and its role in the brain

31 March 2020

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Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation

31 March 2020

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Brain-derived neurotrophic factor is reduced in Alzheimer's disease

31 March 2020

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Region-Specific Neurotrophin Imbalances in Alzheimer Disease

31 March 2020

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Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease.

31 March 2020

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

31 March 2020

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Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.

31 March 2020

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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

31 March 2020

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Etiology and pathogenesis of Parkinson's disease

31 March 2020

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BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

31 March 2020

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Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease

31 March 2020

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Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra

31 March 2020

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Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.

31 March 2020

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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

31 March 2020

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Effects of Brain-derived Neurotrophic Factor on 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in Monkeys

31 March 2020

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Trinucleotide Repeat Disorders

31 March 2020

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31 March 2020

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

31 March 2020

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Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.

31 March 2020

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

31 March 2020

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Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration

31 March 2020

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Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

31 March 2020

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Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

31 March 2020

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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

31 March 2020

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AAV-BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment

31 March 2020

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Neurotrophin signal transduction in the nervous system

31 March 2020

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Amyotrophic lateral sclerosis

31 March 2020

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Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons

31 March 2020

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BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo

31 March 2020

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Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

31 March 2020

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A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

31 March 2020

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Autonomic dysfunction in ALS: a preliminary study on the effects of intrathecal BDNF.

31 March 2020

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A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

31 March 2020

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Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury.

31 March 2020

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Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration

31 March 2020

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Mechanisms of ischemic brain damage

31 March 2020

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Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain

31 March 2020

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Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats

31 March 2020

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Neurotrophins: roles in neuronal development and function

31 March 2020

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Experimental strategies to promote functional recovery after peripheral nerve injuries

31 March 2020

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Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration

31 March 2020

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Transient growth factor delivery sustains regenerated axons after spinal cord injury.

31 March 2020

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Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons.

31 March 2020

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Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury.

31 March 2020

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Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

31 March 2020

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Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury.

31 March 2020

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Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation

31 March 2020

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Dietary restriction started after spinal cord injury improves functional recovery

31 March 2020

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BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats

31 March 2020

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Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression

31 March 2020

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Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications

31 March 2020

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Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder

31 March 2020

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Lower hippocampal volume in patients suffering from depression: a meta-analysis

31 March 2020

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Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects

31 March 2020

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A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression

31 March 2020

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Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder

31 March 2020

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Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications

31 March 2020

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Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

31 March 2020

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Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication

31 March 2020

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Exercise: a behavioral intervention to enhance brain health and plasticity

31 March 2020

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Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

31 March 2020

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Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits

31 March 2020

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Association between BDNF val66 met genotype and episodic memory

31 March 2020

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Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.

31 March 2020

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The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

31 March 2020

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Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume

31 March 2020

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BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia

31 March 2020

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Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain

31 March 2020

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Characteristics of BDNF-induced weight loss.

31 March 2020

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A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants

31 March 2020

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Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity

31 March 2020

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Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

31 March 2020

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A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

31 March 2020

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Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice

31 March 2020

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Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice

31 March 2020

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Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.

31 March 2020

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Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor

31 March 2020

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Hypophagia is induced by intracerebroventricular administration of nerve growth factor

31 March 2020

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Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

31 March 2020

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Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels

31 March 2020

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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

31 March 2020

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

31 March 2020

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Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF in rhesus monkeys

31 March 2020

1 reference

Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease

31 March 2020

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Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

31 March 2020

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Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

31 March 2020

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Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

31 March 2020

1 reference

Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.

31 March 2020

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Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

31 March 2020

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Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease

31 March 2020

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Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

31 March 2020

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DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

31 March 2020

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Lasting epigenetic influence of early-life adversity on the BDNF gene

31 March 2020

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Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory

31 March 2020

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Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

31 March 2020

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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

31 March 2020

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Review of lithium effects on brain and blood

31 March 2020

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Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies

31 March 2020

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Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects

31 March 2020

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Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease

31 March 2020

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Converting a peptide into a drug: strategies to improve stability and bioavailability

31 March 2020

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Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

31 March 2020

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Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms

31 March 2020

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Advances in small molecules promoting neurotrophic function

31 March 2020

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Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.

31 March 2020

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Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats

31 March 2020

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A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

31 March 2020

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Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

31 March 2020

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Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

31 March 2020

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Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.

31 March 2020

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Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice

31 March 2020

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Regulatable gene expression systems for gene therapy applications: progress and future challenges

31 March 2020

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Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors

31 March 2020

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

31 March 2020

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Expression of NGF and NGF receptor mRNAs in the developing brain: evidence for local delivery and action of NGF.

31 March 2020

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Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons.

31 March 2020

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Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS

31 March 2020

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Truncated TrkB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices

31 March 2020

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Trk receptors: roles in neuronal signal transduction

31 March 2020

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Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth.

31 March 2020

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NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

31 March 2020

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Long-distance control of synapse assembly by target-derived NGF.

31 March 2020

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Neurotrophin-evoked rapid excitation through TrkB receptors

31 March 2020

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Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9

31 March 2020

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Nerve growth factor gene delivery: animal models to clinical trials

31 March 2020

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Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.

31 March 2020

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A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys

31 March 2020

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AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters

31 March 2020

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Recombinant AAV-mediated gene delivery to the central nervous system.

31 March 2020

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Ecdysone-controlled expression of transgenes

31 March 2020

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Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons

31 March 2020

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Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat.

31 March 2020

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12 December 2020

Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons

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12 December 2020

Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment

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12 December 2020

Immunocytochemical localization of TrkB in the central nervous system of the adult rat.

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12 December 2020

Purification of a new neurotrophic factor from mammalian brain

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12 December 2020

Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

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12 December 2020

Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis.

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12 December 2020

Identifiers

DOI

10.1038/NRD3366

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Dimensions Publication ID

24 August 2017

1006931113

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