(Q36795351)

16 August 2017

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title

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives (English)

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16 August 2017

Leena N Patel

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16 August 2017

Jennica L Zaro

series ordinal

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16 August 2017

Wei-Chiang Shen

series ordinal

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16 August 2017

publication date

19 April 2007

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16 August 2017

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inferred from page(s)

published in

Pharmaceutical Research

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

1977-1992

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Studies on the internalization mechanism of cationic cell-penetrating peptides.

16 August 2017

cites work

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12 December 2020

Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots

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12 December 2020

Tumor imaging by means of proteolytic activation of cell-penetrating peptides

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12 December 2020

Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide. Role for cell-surface proteoglycans.

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12 December 2020

Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins

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12 December 2020

Enhanced delivery of doxorubicin into the brain via a peptide-vector-mediated strategy: saturation kinetics and specificity.

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12 December 2020

New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy.

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12 December 2020

In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

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12 December 2020

Binding of oligoarginine to membrane lipids and heparan sulfate: structural and thermodynamic characterization of a cell-penetrating peptide

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12 December 2020

Direct observation of anion-mediated translocation of fluorescent oligoarginine carriers into and across bulk liquid and anionic bilayer membranes

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12 December 2020

Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis

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12 December 2020

Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites.

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12 December 2020

Cationic TAT peptide transduction domain enters cells by macropinocytosis.

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12 December 2020

Protein transduction: unrestricted delivery into all cells?

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12 December 2020

Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency

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12 December 2020

Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors.

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12 December 2020

Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes

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12 December 2020

Evidence that membrane transduction of oligoarginine does not require vesicle formation

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12 December 2020

Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells

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12 December 2020

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

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12 December 2020

Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo

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12 December 2020

TAT-mediated protein transduction and targeted delivery of fusion proteins into mitochondria of breast cancer cells.

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12 December 2020

Plasmon-waveguide resonance and impedance spectroscopy studies of the interaction between penetratin and supported lipid bilayer membranes

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12 December 2020

Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery

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12 December 2020

Ability of the Tat basic domain and VP22 to mediate cell binding, but not membrane translocation of the diphtheria toxin A-fragment

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12 December 2020

HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis

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12 December 2020

Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease

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12 December 2020

Intracellular cargo delivery using tat peptide and derivatives

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12 December 2020

Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells

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12 December 2020

Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells

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12 December 2020

Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide

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12 December 2020

Pathway for polyarginine entry into mammalian cells

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12 December 2020

Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation.

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12 December 2020

Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters

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12 December 2020

siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene

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12 December 2020

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

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12 December 2020

Cell-penetrating peptides: mechanism and kinetics of cargo delivery

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12 December 2020

Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states

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12 December 2020

Structural requirements for cellular uptake of alpha-helical amphipathic peptides.

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12 December 2020

Cell-penetrating peptides are excluded from the mitochondrial matrix

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12 December 2020

Intracellular delivery of monoclonal antibodies

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12 December 2020

The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists

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12 December 2020

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

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12 December 2020

Evaluation of transportan 10 in PEI mediated plasmid delivery assay

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12 December 2020

Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans

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12 December 2020

Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells.

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12 December 2020

Anion-mediated transfer of polyarginine across liquid and bilayer membranes

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12 December 2020

Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58)

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12 December 2020

Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models

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12 December 2020

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

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12 December 2020

Novel branching membrane translocational peptide as gene delivery vector

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12 December 2020

In vitro uptake and stability study of pVEC and its all-D analog

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12 December 2020

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

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12 December 2020

Effects of cargo molecules on the cellular uptake of arginine-rich cell-penetrating peptides

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12 December 2020

"SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers

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12 December 2020

Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans.

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12 December 2020

Principles of tumor suppression

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12 December 2020

Protein cargo delivery properties of cell-penetrating peptides. A comparative study

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12 December 2020

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

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12 December 2020

A giant protease with potential to substitute for some functions of the proteasome

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12 December 2020

The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals

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12 December 2020

Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat.

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12 December 2020

Human immunodeficiency virus type 1 Tat activity in human neuronal cells: uptake and trans-activation

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12 December 2020

In vivo protein transduction: delivery of a biologically active protein into the mouse

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12 December 2020

Cytosolic delivery of a p16-peptide oligoarginine conjugate for inhibiting proliferation of MCF7 cells

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12 December 2020

Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides

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12 December 2020

A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides

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12 December 2020

Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions

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12 December 2020

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.

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12 December 2020

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

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12 December 2020

Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide

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12 December 2020

Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine

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12 December 2020

Novel Tat-Peptide Chelates for Direct Transduction of Technetium-99m and Rhenium into Human Cells for Imaging and Radiotherapy

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12 December 2020

Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI.

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12 December 2020

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12 December 2020

Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells

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12 December 2020

Polyarginine enters cells more efficiently than other polycationic homopolymers

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12 December 2020

Charge-dependent translocation of the Trojan peptide penetratin across lipid membranes.

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12 December 2020

A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity.

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12 December 2020

Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

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12 December 2020

Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo

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12 December 2020

Possible existence of common internalization mechanisms among arginine-rich peptides

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12 December 2020

Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo

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12 December 2020

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

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12 December 2020

A rapid method for labelling CD4+ T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro.

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12 December 2020

Homeodomain-derived peptides. In and out of the cells

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12 December 2020

Specific redistribution of cell-penetrating peptides from endosomes to the cytoplasm and nucleus upon laser illumination

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12 December 2020

Arginine-mediated RNA recognition: the arginine fork.

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12 December 2020

Targeting DNA mismatches with rhodium intercalators functionalized with a cell-penetrating peptide

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12 December 2020

Penetratin and related cell-penetrating cationic peptides can translocate across lipid bilayers in the presence of a transbilayer potential

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12 December 2020

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide

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12 December 2020

Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins

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12 December 2020

Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways.

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12 December 2020

Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT

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12 December 2020

Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.

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12 December 2020

Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate

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12 December 2020

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

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12 December 2020

Trojan p16 peptide suppresses pancreatic cancer growth and prolongs survival in mice

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12 December 2020

Amphipathic peptides and drug delivery

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12 December 2020

Improvement of Porphyrin Cellular Delivery and Activity by Conjugation to a Carrier Peptide

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12 December 2020

Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis

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12 December 2020

Arginine containing peptides as delivery vectors.

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12 December 2020

Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake

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12 December 2020

Induction of melanoma cell apoptosis and inhibition of tumor growth using a cell-permeable Survivin antagonist

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12 December 2020

Transport of surface-modified nanoparticles through cell monolayers

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12 December 2020

The proteasome: structure, function, and role in the cell

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12 December 2020

Nucleocytoplasmic transport of plasmid DNA: a perilous journey from the cytoplasm to the nucleus

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12 December 2020

Passage of cell-penetrating peptides across a human epithelial cell layer in vitro

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12 December 2020

Macro-branched cell-penetrating peptide design for gene delivery

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12 December 2020

Photochemically enhanced cellular delivery of cell penetrating peptide-PNA conjugates

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12 December 2020

Quantitative comparison of membrane transduction and endocytosis of oligopeptides

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12 December 2020

Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis

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12 December 2020

Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

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12 December 2020

Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.

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12 December 2020

Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate

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12 December 2020

In vivo identification of ribonucleoprotein-RNA interactions

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12 December 2020

Translocation of branched-chain arginine peptides through cell membranes: flexibility in the spatial disposition of positive charges in membrane-permeable peptides

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12 December 2020

Cell surface heparan sulfate proteoglycans

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12 December 2020

Delivery of bioactive molecules into the cell: the Trojan horse approach

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12 December 2020

Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.

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12 December 2020

Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size

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12 December 2020

D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia

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12 December 2020

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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12 December 2020

Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells

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12 December 2020

Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement

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12 December 2020

The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence

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12 December 2020

Chances and pitfalls of cell penetrating peptides for cellular drug delivery

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12 December 2020

Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus.

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12 December 2020

Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma

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12 December 2020

Intracellular localization and sustained prodrug cell killing activity of TAT-HSVTK fusion protein in hepatocelullar carcinoma cells.

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12 December 2020

Cellular uptake of the tat protein from human immunodeficiency virus

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12 December 2020

Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time

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12 December 2020

High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression.

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12 December 2020

Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

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12 December 2020

Homeodomain-DNA recognition

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12 December 2020

Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity

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12 December 2020

Direct and rapid cytosolic delivery using cell-penetrating peptides mediated by pyrenebutyrate

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12 December 2020

Regulated portals of entry into the cell

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12 December 2020

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

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12 December 2020

Messenger proteins: homeoproteins, TAT and others

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12 December 2020

Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

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12 December 2020

Poly-arginine-fused calpastatin peptide, a living cell membrane-permeable and specific inhibitor for calpain

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12 December 2020

Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms

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12 December 2020

Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery

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12 December 2020

The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction.

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12 December 2020

10.1007/S11095-007-9303-7

Identifiers

DOI

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16 August 2017

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