(Q36146937)

12 August 2017

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title

Autophagy in metazoans: cell survival in the land of plenty (English)

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12 August 2017

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Craig B Thompson

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12 August 2017

Julian J Lum

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12 August 2017

Ralph J DeBerardinis

series ordinal

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12 August 2017

publication date

1 June 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

published in

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

439-448

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Rab7 Prevents Growth Factor-Independent Survival by Inhibiting Cell-Autonomous Nutrient Transporter Expression

12 August 2017

cites work

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Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

21 January 2018

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Cellular autophagy: surrender, avoidance and subversion by microorganisms

21 January 2018

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Regulation and role of autophagy in mammalian cells

21 January 2018

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Autophagy: a regulated bulk degradation process inside cells

21 January 2018

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

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Autophagy as a cell death and tumor suppressor mechanism

21 January 2018

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Autophagy in yeast: a review of the molecular machinery

21 January 2018

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Yeast autophagosomes: de novo formation of a membrane structure

21 January 2018

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Molecular dissection of autophagy: two ubiquitin-like systems

21 January 2018

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Diversity of signaling controls of macroautophagy in mammalian cells.

21 January 2018

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Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae

21 January 2018

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Dictyostelium macroautophagy mutants vary in the severity of their developmental defects.

21 January 2018

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Ultrastructural and biochemical characterization of autophagy in higher plant cells subjected to carbon deprivation: control by the supply of mitochondria with respiratory substrates

21 January 2018

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Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene

21 January 2018

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Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy

21 January 2018

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The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana

21 January 2018

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Autophagy genes are essential for dauer development and life-span extension in C. elegans

21 January 2018

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Role and regulation of starvation-induced autophagy in the Drosophila fat body

21 January 2018

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Developmental biology: survival by self-digestion.

21 January 2018

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Autophagic degradation of glycogen in skeletal muscles of the newborn rat

21 January 2018

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Random, presumably hydrolytic, and lysosomal glycogenolysis in the livers of rats treated with phlorizin and of newborn rats

21 January 2018

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An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats

21 January 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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Alkylating DNA damage stimulates a regulated form of necrotic cell death

21 January 2018

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

21 January 2018

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

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Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

21 January 2018

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Growth factors can influence cell growth and survival through effects on glucose metabolism

21 January 2018

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

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Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

21 January 2018

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Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells.

21 January 2018

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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

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Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

21 January 2018

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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

21 January 2018

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Upstream and downstream of mTOR

21 January 2018

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A signaling pathway to translational control

21 January 2018

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mTOR integrates amino acid- and energy-sensing pathways

21 January 2018

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The target of rapamycin (TOR) proteins

21 January 2018

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The TOR pathway: a target for cancer therapy

21 January 2018

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 January 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

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Mammalian TOR: a homeostatic ATP sensor

21 January 2018

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Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes

21 January 2018

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Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase

21 January 2018

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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

21 January 2018

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Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

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Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

21 January 2018

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Dissection of autophagosome biogenesis into distinct nucleation and expansion steps

21 January 2018

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Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

21 January 2018

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Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

21 January 2018

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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

21 January 2018

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Uth1p is involved in the autophagic degradation of mitochondria

21 January 2018

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Macropexophagy in Hansenula polymorpha: facts and views

21 January 2018

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Peroxisome biogenesis and selective degradation converge at Pex14p

21 January 2018

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Lost in translation: dysregulation of cap-dependent translation and cancer

21 January 2018

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Will mTOR inhibitors make it as cancer drugs?

21 January 2018

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

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Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

21 January 2018

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The autophagosomal-lysosomal compartment in programmed cell death

21 January 2018

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Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

21 January 2018

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The Drosophila homolog of Aut1 is essential for autophagy and development.

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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Autophagy regulates the processing of amino terminal huntingtin fragments

21 January 2018

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Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

21 January 2018

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Autophagy defends cells against invading group A Streptococcus

21 January 2018

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Cytoplasmic bacteria can be targets for autophagy

21 January 2018

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Ras is involved in the negative control of autophagy through the class I PI3-kinase

21 January 2018

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c-myc induces autophagy in rat 3Y1 fibroblast cells.

21 January 2018

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The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

21 January 2018

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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

21 January 2018

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Ceramide: second messenger or modulator of membrane structure and dynamics?

21 January 2018

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Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert

21 January 2018

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Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1

21 January 2018

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

21 January 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

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The role of PI 3-kinase in insulin action

21 January 2018

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Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum

21 January 2018

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The role of autophagy during the early neonatal starvation period

31 March 2020

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Physicochemical and ultrastructural studies on glycogenosomes in newborn rat hepatocytes

31 March 2020

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Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

31 March 2020

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Fibroblast growth factor-dependent metabolism of hypoxanthine via the salvage pathway for purine synthesis in porcine aortic endothelial cells

31 March 2020

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Evidence for early mitogenic stimulation of metabolic flux through phosphoribosyl pyrophosphate into nucleotides in Swiss 3T3 cells

31 March 2020

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Mitogenic enhancement of purine base phosphoribosylation in Swiss mouse 3T3 cells

31 March 2020

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Akt stimulates aerobic glycolysis in cancer cells

31 March 2020

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

31 March 2020

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The mitochondrial permeability transition initiates autophagy in rat hepatocytes.

31 March 2020

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Mechanisms of caspase-independent neuronal death: energy depletion and free radical generation.

31 March 2020

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

31 March 2020

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Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases

31 March 2020

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Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

31 March 2020

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Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells

31 March 2020

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Escape of intracellular Shigella from autophagy

31 March 2020

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

31 March 2020

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Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

31 March 2020

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Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1660

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12 August 2017

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