(Q35743138)

10 August 2017

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title

Autophagy as a cell death and tumor suppressor mechanism (English)

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10 August 2017

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Devrim Gozuacik

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10 August 2017

Adi Kimchi

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10 August 2017

language of work or name

English

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publication date

1 April 2004

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10 August 2017

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

2891-2906

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Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Tissue protein turnover during liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Primary phase of hepatocytic autophagocytosis under ischaemic conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Reduced rates of proteolysis in transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

A ubiquitin-like system mediates protein lipidation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

DAP kinase links the control of apoptosis to metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Formation process of autophagosome is traced with Apg8/Aut7p in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Regulation of lysosomal autophagy in transformed and non-transformed mouse fibroblasts under several growth conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Regulation of protein degradation in normal and transformed human bronchial epithelial cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Four deaths and a funeral: from caspases to alternative mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

1 reference

7 January 2021

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

A protein conjugation system essential for autophagy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Role of the Apg12 conjugation system in mammalian autophagy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Differences in the rates of protein degradation in untransformed and transformed cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Protein turnover and cellular autophagy in growing and growth-inhibited 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

DAP kinase-a proapoptotic gene that functions as a tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Cellular autophagic capacity is highly increased in azaserine-induced premalignant atypical acinar nodule cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The morphology of various types of cell death in prenatal tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Preferential loss of Death Associated Protein kinase expression in invasive pituitary tumours is associated with either CpG island methylation or homozygous deletion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

PTEN controls tumor-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Phoxy lipids: revealing PX domains as phosphoinositide binding modules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Overall proteolysis in perfused and subfractionated chemically induced malignant hepatoma of rat: effects of amino acids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207521

7 January 2021

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1093/EMBOJ/19.21.5720

Identifiers

DOI

10.1038/SJ.ONC.1207521

1 reference

Dimensions Publication ID

10 August 2017

1050297952

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Fatcat ID

release_6b5f5kmoevdpdgxbssjaujal6e

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6b5f5kmoevdpdgxbssjaujal6e

24 November 2022

mapped directly with Wikidata item

1 reference