(Q34418068)

2 August 2017

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title

Autoreactivity, dynamic tuning and selectivity (English)

1 reference

2 August 2017

Grossman Z

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2 August 2017

Paul WE

series ordinal

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2 August 2017

publication date

1 December 2001

1 reference

Current Opinion in Immunology

2 August 2017

published in

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

687-698

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Quantitation of the cell surface level of Ld resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression

1 reference

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7 January 2021

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

1 reference

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7 January 2021

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Protein molecules as computational elements in living cells

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https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

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7 January 2021

Approaching the asymptote? Evolution and revolution in immunology

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7 January 2021

How does the immune system distinguish self from nonself?

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7 January 2021

Danger: the view from the bottom of the cliff

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7 January 2021

Self-tolerance: context dependent tuning of T cell antigen recognition

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7 January 2021

Recognition of self, balance of growth and competition: horizontal networks regulate immune responsiveness.

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7 January 2021

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

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7 January 2021

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

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7 January 2021

Partial signaling by CD8+ T cells in response to antagonist ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

T cell receptor antagonists and partial agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

T cell activation determined by T cell receptor number and tunable thresholds.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

T cell responses are governed by avidity and co-stimulatory thresholds

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells

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7 January 2021

A logical analysis of T cell activation and anergy

1 reference

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7 January 2021

Information transfer at the immunological synapse.

1 reference

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7 January 2021

Functional flexibility in T cells: independent regulation of CD4+ T cell proliferation and effector function in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

From synapses to immunological memory: the role of sustained T cell stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Selection of the T cell repertoire.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Positive selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Cellular tolerance as a dynamic state of the adaptable lymphocyte

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Anergic T cells actively suppress T cell responses via the antigen-presenting cell

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Anergic T cells act as suppressor cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Modifications of CD8+ T cell function during in vivo memory or tolerance induction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

T cell selection and autoimmunity: flexibility and tuning

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Mature T cell reactivity altered by peptide agonist that induces positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The agonist-antagonist balance in positive selection.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Interactions with multiple peptide ligands determine the fate of developing thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Immunological function of a defined T-cell population tolerized to low-affinity self antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Fine tuning of TCR signaling by CD5.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Negative selection during the peripheral immune response to antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Immunology taught by viruses

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Localization dose and time of antigens determine immune reactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

In vivo activation of antigen-specific CD4 T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Mobilizing dendritic cells for tolerance, priming, and chronic inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Other functions, other genes: alternative activation of antigen-presenting cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Dendritic cells and prospects for transplantation tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

‘Anergic’ T cells Modulate the T-cell Activating Capacity of Antigen-presenting Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Anergic T cells inhibit the antigen-presenting function of dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The CD8 response on autopilot.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The interplay between the duration of TCR and cytokine signaling determines T cell polarization

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Migration and function of antigen-primed nonpolarized T lymphocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Autologous regulation of naive T cell homeostasis within the T cell compartment.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The art of the probable: system control in the adaptive immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Regulatory T cells: the physiology of autoreactivity in dominant tolerance and "quality control" of immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

A kinetic basis for T cell receptor repertoire selection during an immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

CD4 augments the response of a T cell to agonist but not to antagonist ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Kinetic proofreading in T-cell receptor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Cooperative enhancement of specificity in a lattice of T cell receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

Cross-antagonism of a T cell clone expressing two distinct T cell receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

An amplified sensitivity arising from covalent modification in biological systems

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2801%2900280-1

7 January 2021

10.1016/S0952-7915(01)00280-1

Identifiers

DOI

1 reference

2 August 2017

1 reference