(Q34333858)

1 August 2017

title

Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing (English)

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1 August 2017

Ning Sun

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1 August 2017

Huimin Zhao

series ordinal

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1 August 2017

publication date

7 April 2013

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Biotechnology and Bioengineering

1 August 2017

published in

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1 August 2017

volume

110

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1 August 2017

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1 August 2017

page(s)

1811-1821

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Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases

1 August 2017

cites work

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In vivo genome editing using a high-efficiency TALEN system

21 January 2018

1 reference

Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology

21 January 2018

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Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

1 reference

TAL effectors: customizable proteins for DNA targeting

21 January 2018

1 reference

Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers

21 January 2018

1 reference

Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers.

21 January 2018

1 reference

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

21 January 2018

1 reference

Efficient TALEN-mediated gene knockout in livestock

21 January 2018

1 reference

Genome Engineering With Zinc-Finger Nucleases

21 January 2018

1 reference

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

21 January 2018

1 reference

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

1 reference

Targeting DNA double-strand breaks with TAL effector nucleases

21 January 2018

1 reference

Targeting G with TAL effectors: a comparison of activities of TALENs constructed with NN and NK repeat variable di-residues

21 January 2018

1 reference

Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains

21 January 2018

1 reference

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration

21 January 2018

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Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome

21 January 2018

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Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

21 January 2018

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Recognition of methylated DNA by TAL effectors

21 January 2018

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A TALEN genome-editing system for generating human stem cell-based disease models

21 January 2018

1 reference

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

21 January 2018

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A one pot, one step, precision cloning method with high throughput capability

21 January 2018

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Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region

21 January 2018

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Engineering synthetic TAL effectors with orthogonal target sites

21 January 2018

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Transcriptional activators of human genes with programmable DNA-specificity

21 January 2018

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Genetic engineering of human pluripotent cells using TALE nucleases

21 January 2018

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Heritable gene targeting in zebrafish using customized TALENs.

21 January 2018

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Efficient genome editing in zebrafish using a CRISPR-Cas system

21 January 2018

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Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis

21 January 2018

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RNA-guided editing of bacterial genomes using CRISPR-Cas systems

21 January 2018

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RNA-programmed genome editing in human cells

21 January 2018

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TALENs: a widely applicable technology for targeted genome editing

21 January 2018

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Surrogate reporters for enrichment of cells with nuclease-induced mutations

21 January 2018

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Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)

21 January 2018

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TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

21 January 2018

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Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

21 January 2018

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Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification

21 January 2018

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High-efficiency TALEN-based gene editing produces disease-resistant rice.

21 January 2018

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Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression

21 January 2018

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Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy

21 January 2018

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Highly efficient and specific genome editing in silkworm using custom TALENs

21 January 2018

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De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

21 January 2018

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Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein.

21 January 2018

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The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

21 January 2018

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RNA-guided human genome engineering via Cas9

21 January 2018

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Conserved role of intragenic DNA methylation in regulating alternative promoters

21 January 2018

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Chimeric TALE recombinases with programmable DNA sequence specificity

21 January 2018

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An improved zinc-finger nuclease architecture for highly specific genome editing

21 January 2018

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A TALE nuclease architecture for efficient genome editing

21 January 2018

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Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

21 January 2018

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Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

21 January 2018

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Assembly of custom TALE-type DNA binding domains by modular cloning

21 January 2018

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A simple cipher governs DNA recognition by TAL effectors

21 January 2018

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21 January 2018

Tell me a tale of TALEs

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A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

21 January 2018

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Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

21 January 2018

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Advances in targeted genome editing

21 January 2018

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Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications

21 January 2018

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Unexpected failure rates for modular assembly of engineered zinc fingers

21 January 2018

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Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assembly

21 January 2018

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FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

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Efficient disruption of endogenous Bombyx gene by TAL effector nucleases.

21 January 2018

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Targeted gene disruption in somatic zebrafish cells using engineered TALENs

21 January 2018

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A transcription activator-like effector toolbox for genome engineering

21 January 2018

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A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

21 January 2018

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Rapid and efficient gene modification in rice and Brachypodium using TALENs

21 January 2018

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Gene knockout using transcription activator-like effector nucleases (TALENs) reveals that human NDUFA9 protein is essential for stabilizing the junction between membrane and matrix arms of complex I

21 January 2018

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Conservation and divergence of DNA methylation in eukaryotes: new insights from single base-resolution DNA methylomes

21 January 2018

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Recent advances in targeted genome engineering in mammalian systems

21 January 2018

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Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease.

21 January 2018

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Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

21 January 2018

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Knockout rats generated by embryo microinjection of TALENs.

21 January 2018

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Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs

21 January 2018

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Transcription activator-like effector proteins induce the expression of the frataxin gene

21 January 2018

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Genome editing with engineered zinc finger nucleases

21 January 2018

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Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation.

21 January 2018

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An integrated chip for the high-throughput synthesis of transcription activator-like effectors.

21 January 2018

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Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases

21 January 2018

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Assembly of designer TAL effectors by Golden Gate cloning

21 January 2018

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The type III effectors of Xanthomonas

21 January 2018

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Targeted genome editing across species using ZFNs and TALENs

21 January 2018

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Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

21 January 2018

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Transcription activator-like effector nucleases enable efficient plant genome engineering.

21 January 2018

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Colonization of Rice Leaf Blades by an African Strain of Xanthomonas oryzae pv. oryzae Depends on a New TAL Effector That Induces the Rice Nodulin-3 Os11N3 Gene

21 January 2018

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21 January 2018

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