(Q33899678)

29 July 2017

title

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia (English)

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29 July 2017

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Seth B Coffelt

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Craig Murdoch

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Florian R Greten

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Randall S Johnson

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Adrian L Harris

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Subhra K Biswas

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29 July 2017

Hsin-Yu Fang

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29 July 2017

Russell Hughes

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29 July 2017

Hongxia Z Imityaz

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29 July 2017

M Celeste Simon

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29 July 2017

Erik Fredlund

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29 July 2017

Jordi Rius

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29 July 2017

Claire E Lewis

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29 July 2017

language of work or name

English

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publication date

19 May 2009

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29 July 2017

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29 July 2017

volume

114

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29 July 2017

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29 July 2017

page(s)

844-859

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The impact of O2 availability on human cancer

29 July 2017

cites work

1 reference

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5 July 2018

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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

5 July 2018

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Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

5 July 2018

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Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.

5 July 2018

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

5 July 2018

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

5 July 2018

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Role of hypoxia-inducible transcription factors 1alpha and 2alpha in the regulation of plasminogen activator inhibitor-1 expression in a human trophoblast cell line

5 July 2018

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

5 July 2018

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The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

5 July 2018

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Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

5 July 2018

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Activation of hypoxia-inducible factor 1 during macrophage differentiation

5 July 2018

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Distinct role of macrophages in different tumor microenvironments

5 July 2018

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

5 July 2018

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Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies

5 July 2018

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Macrophage migration and gene expression in response to tumor hypoxia

5 July 2018

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Hypoxia and angiogenesis in rheumatoid arthritis

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

5 July 2018

1 reference

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Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation

5 July 2018

1 reference

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

5 July 2018

1 reference

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Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

HIF-1alpha is essential for myeloid cell-mediated inflammation

5 July 2018

1 reference

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Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Hypoxia--a key regulatory factor in tumour growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

5 July 2018

1 reference

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

An interleukin-4-induced transcription factor: IL-4 Stat

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882173

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

29 October 2018

1 reference

12 December 2020

Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli

1 reference

12 December 2020

Evidence of hypoxic areas within the arterial wall in vivo

1 reference

12 December 2020

Transcriptome of Hypoxic Immature Dendritic Cells: Modulation of Chemokine/Receptor Expression

1 reference

12 December 2020

Effects of hypoxia on transcription factor expression in human monocytes and macrophages

1 reference

12 December 2020

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile

1 reference

12 December 2020

10.1182/BLOOD-2008-12-195941

Identifiers

DOI

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29 July 2017

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29 July 2017

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