(Q33840458)

29 July 2017

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title

A critical role for telomeres in suppressing and facilitating carcinogenesis (English)

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29 July 2017

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Artandi SE

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29 July 2017

DePinho RA

series ordinal

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29 July 2017

publication date

1 February 2000

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Current Opinion in Genetics & Development

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

39-46

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The serial cultivation of human diploid cell strains

29 July 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Variability at the telomeres of the human X/Y pseudoautosomal region

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7 January 2021

Origin of Concatemeric T7DNA

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

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7 January 2021

Telomerase catalytic subunit homologs from fission yeast and human

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7 January 2021

Telomere length predicts replicative capacity of human fibroblasts

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7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Control of telomere length by the human telomeric protein TRF1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Mammalian telomeres end in a large duplex loop

1 reference

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7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

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7 January 2021

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Increased activity of p53 in senescing fibroblasts

1 reference

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7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

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7 January 2021

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1 reference

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7 January 2021

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

1 reference

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

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7 January 2021

The INK4A/ARF locus and its two gene products

1 reference

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7 January 2021

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

1 reference

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7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Expression of mouse telomerase catalytic subunit in embryos and adult tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomerase regulation during entry into the cell cycle in normal human T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Mechanism of telomerase induction during T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Direct activation of TERT transcription by c-MYC.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

An alternative pathway for yeast telomere maintenance rescues est1- senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

For better or worse? Telomerase inhibition and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Creation of human tumour cells with defined genetic elements

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2899%2900047-7

7 January 2021

10.1016/S0959-437X(99)00047-7

Identifiers

DOI

1 reference

release_4odj4qv5efbrjmi2556gznx2oq

29 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4odj4qv5efbrjmi2556gznx2oq

24 November 2022

mapped directly with Wikidata item

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